STRINGSTRING
SLBP2 SLBP2 RPRD1B RPRD1B LEO1 LEO1 APLP1 APLP1 ENSBTAP00000059167 ENSBTAP00000059167 LOC112445820 LOC112445820 SCAF8 SCAF8 APP APP CLP1 CLP1 SLBP SLBP PAPOLB PAPOLB TENT2 TENT2 CPSF7 CPSF7 CPSF4 CPSF4 ENSBTAP00000069383 ENSBTAP00000069383 PAPOLA PAPOLA CPSF6 CPSF6 CPSF1 CPSF1 ENSBTAP00000072644 ENSBTAP00000072644 MTPAP MTPAP RPRD1A RPRD1A WDR33 WDR33 CSTF1 CSTF1 PAPOLG PAPOLG CSTF3 CSTF3 NCBP2 NCBP2 PNPT1 PNPT1 NUDT21 NUDT21 CPSF2 CPSF2 LSM11 LSM11 TUT1 TUT1 SSU72 SSU72 ZNF473 ZNF473 CSTF2T CSTF2T SYMPK SYMPK RPRD2 RPRD2 PCF11 PCF11 CDC73 CDC73 LOC617499 LOC617499 CPSF3 CPSF3 PAF1 PAF1 FIP1L1 FIP1L1 ZC3H3 ZC3H3 LSM10 LSM10 CSTF2 CSTF2 AHCYL1 AHCYL1 E1BAB2_BOVIN E1BAB2_BOVIN NCBP1 NCBP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLBP2Stem loop binding protein 2 short isoform. (147 aa)
RPRD1BRegulation of nuclear pre-mRNA domain containing 1B. (345 aa)
LEO1LEO1 homolog, Paf1/RNA polymerase II complex component. (694 aa)
APLP1Amyloid beta precursor like protein 1. (642 aa)
ENSBTAP00000059167Uncharacterized protein. (221 aa)
LOC112445820RNA polymerase II subunit A C-terminal domain phosphatase SSU72-like. (195 aa)
SCAF8SR-related CTD associated factor 8. (1268 aa)
APPGamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (770 aa)
CLP1Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this pho [...] (425 aa)
SLBPStem-loop binding protein. (400 aa)
PAPOLBUncharacterized protein. (684 aa)
TENT2Poly(A) RNA polymerase GLD2; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation. Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs. Belongs to the DNA polymerase type-B-like family. GLD2 subfamily. (576 aa)
CPSF7Cleavage and polyadenylation specific factor 7. (471 aa)
CPSF4Cleavage and polyadenylation-specificity factor subunit 4. (263 aa)
ENSBTAP00000069383PAP_central domain-containing protein. (221 aa)
PAPOLAPoly(A) polymerase alpha; Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C- terminus. (740 aa)
CPSF6Cleavage and polyadenylation specificity factor subunit 6; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (588 aa)
CPSF1Cleavage and polyadenylation specificity factor subunit 1; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity); Belongs to the CPSF1 family. (1469 aa)
ENSBTAP00000072644Uncharacterized protein. (243 aa)
MTPAPMitochondrial poly(A) polymerase. (583 aa)
RPRD1ARegulation of nuclear pre-mRNA domain-containing protein 1A; Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle. (312 aa)
WDR33WD repeat domain 33. (1336 aa)
CSTF1Cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa. (431 aa)
PAPOLGPAPOLG protein. (740 aa)
CSTF3Cleavage stimulation factor subunit 3. (717 aa)
NCBP2Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The C [...] (156 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1. (783 aa)
NUDT21Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (227 aa)
CPSF2Cleavage and polyadenylation specificity factor subunit 2; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing (By similarity). (782 aa)
LSM11LSM11, U7 small nuclear RNA associated. (359 aa)
TUT1Speckle targeted PIP5K1A-regulated poly(A) polymerase; Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher tha [...] (871 aa)
SSU72RNA polymerase II subunit A C-terminal domain phosphatase SSU72; Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK (By similarity). (194 aa)
ZNF473Zinc finger protein 473. (853 aa)
CSTF2TCleavage stimulation factor subunit 2 tau variant. (632 aa)
SYMPKSymplekin. (1271 aa)
RPRD2Regulation of nuclear pre-mRNA domain containing 2. (1490 aa)
PCF11PCF11 cleavage and polyadenylation factor subunit. (1685 aa)
CDC73Cell division cycle 73. (531 aa)
LOC617499Uncharacterized protein. (195 aa)
CPSF3Cleavage and polyadenylation specificity factor subunit 3; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3'- end-processing endonuclease. Also involved in the histone 3'-end pre- mRNA processing. U7 snRNP-dependent protein that induces both the 3'- endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' [...] (684 aa)
PAF1RNA polymerase II-associated factor 1 homolog; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription [...] (532 aa)
FIP1L1Factor interacting with PAPOLA and CPSF1. (568 aa)
ZC3H3Zinc finger CCCH-type containing 3. (878 aa)
LSM10LSM10, U7 small nuclear RNA associated. (122 aa)
CSTF2Cleavage stimulation factor subunit 2; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity). (592 aa)
AHCYL1Adenosylhomocysteinase like 1. (530 aa)
E1BAB2_BOVINUncharacterized protein. (194 aa)
NCBP1Nuclear cap binding protein subunit 1. (790 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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