STRINGSTRING
AKAP14 AKAP14 WASF1 WASF1 AKAP7-2 AKAP7-2 WASF2 WASF2 PRKACA PRKACA ARFGEF2 ARFGEF2 AKAP9 AKAP9 EZR EZR AKAP1 AKAP1 C2H2orf88 C2H2orf88 PRRC1 PRRC1 PJA2 PJA2 SPATC1L SPATC1L GSKIP GSKIP RYR2 RYR2 AKAP11 AKAP11 ARFGEF1 ARFGEF1 WASF3 WASF3 ACBD3 ACBD3 AKAP5 AKAP5 AKAP7 AKAP7 KCNQ1 KCNQ1 AKAP8L AKAP8L AKAP8 AKAP8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKAP14A-kinase anchoring protein 14. (194 aa)
WASF1Wiskott-Aldrich syndrome protein family member 1; Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity); Belongs to the SCAR/WAVE family. (570 aa)
AKAP7-2AKAP7_RIRII_bdg domain-containing protein. (225 aa)
WASF2Wiskott-Aldrich syndrome protein family member 2; Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity); Belongs to the SCAR/WAVE family. (639 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (351 aa)
ARFGEF2ADP ribosylation factor guanine nucleotide exchange factor 2. (1779 aa)
AKAP9A-kinase anchoring protein 9. (3703 aa)
EZREzrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity). (670 aa)
AKAP1A-kinase anchoring protein 1. (843 aa)
C2H2orf88Small membrane A-kinase anchor protein; Binds to type I regulatory subunits of protein kinase A (PKA- RI) and may anchor/target them to the plasma membrane; Belongs to the small membrane AKAP family. (95 aa)
PRRC1Proline rich coiled-coil 1. (445 aa)
PJA2Praja ring finger ubiquitin ligase 2. (709 aa)
SPATC1LSpermatogenesis and centriole associated 1 like. (341 aa)
GSKIPGSK3B-interacting protein; A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron [...] (139 aa)
RYR2Ryanodine receptor 2. (4904 aa)
AKAP11A-kinase anchoring protein 11. (1860 aa)
ARFGEF1Brefeldin A-inhibited guanine nucleotide-exchange protein 1; Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and [...] (1849 aa)
WASF3WASP family member 3. (501 aa)
ACBD3Acyl-CoA binding domain containing 3. (528 aa)
AKAP5A-kinase anchor protein 5; May anchor the PKA kinase to cytoskeletal and/or organelle- associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. (428 aa)
AKAP7A-kinase anchoring protein 7. (329 aa)
KCNQ1Uncharacterized protein; Belongs to the potassium channel family. (670 aa)
AKAP8LA-kinase anchoring protein 8 like; Belongs to the AKAP95 family. (649 aa)
AKAP8A-kinase anchoring protein 8; Belongs to the AKAP95 family. (683 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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