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| | SCN5A | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2022 aa) |
| | CACNG3 | Voltage-dependent calcium channel gamma-3 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. (315 aa) |
| | LRRC52 | Leucine rich repeat containing 52. (320 aa) |
| | CATSPERD | Cation channel sperm-associated protein subunit delta; Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane. (781 aa) |
| | TRPV5 | Transient receptor potential cation channel subfamily V member 5; Belongs to the transient receptor (TC 1.A.4) family. (731 aa) |
| | CACNB1 | Voltage-dependent L-type calcium channel subunit beta-1; Regulatory subunit of L-type calcium channels. Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore- forming subunit and increases the presence of the channel complex at the cell membrane. Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming [...] (643 aa) |
| | CNGA1 | cGMP-gated cation channel alpha-1; Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential. (690 aa) |
| | TRPC1 | Short transient receptor potential channel 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. (803 aa) |
| | CACNB4 | Calcium voltage-gated channel auxiliary subunit beta 4. (520 aa) |
| | SCN9A | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1987 aa) |
| | DLG4 | Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (721 aa) |
| | SCNN1A | Amiloride-sensitive sodium channel subunit alpha; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception. Belongs to the amilori [...] (650 aa) |
| | KCNG1 | Potassium voltage-gated channel modifier subfamily G member 1; Belongs to the potassium channel family. (514 aa) |
| | KCNMB4 | Potassium calcium-activated channel subfamily M regulatory beta subunit 4. (210 aa) |
| | SCN1B | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. (218 aa) |
| | MCU | Mitochondrial calcium uniporter. (351 aa) |
| | LRRC55 | Leucine rich repeat containing 55. (311 aa) |
| | KCNK1 | Potassium channel subfamily K member 1; Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues. Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium. The homodimer has very low potassium [...] (336 aa) |
| | SCN4A | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1734 aa) |
| | GRIA2 | Glutamate ionotropic receptor AMPA type subunit 2. (883 aa) |
| | CNGA4 | Cyclic nucleotide gated channel subunit alpha 4. (575 aa) |
| | DPP10 | Dipeptidyl peptidase like 10; Belongs to the peptidase S9B family. (675 aa) |
| | KCNC1 | Potassium voltage-gated channel subfamily C member 1; Belongs to the potassium channel family. (585 aa) |
| | MICU1 | Calcium uptake protein 1, mitochondrial; Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. [...] (478 aa) |
| | CTTN | Cortactin. (538 aa) |
| | TRPM4 | Transient receptor potential cation channel subfamily M member 4. (1203 aa) |
| | KCNJ3 | G protein-activated inward rectifier potassium channel 1; This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating t [...] (501 aa) |
| | GRIA4 | Glutamate ionotropic receptor AMPA type subunit 4. (433 aa) |
| | CACNG7 | Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa) |
| | CACNG8 | Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (426 aa) |
| | CACNG1 | Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (223 aa) |
| | KCNA5 | Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (598 aa) |
| | KCNS2 | Potassium voltage-gated channel modifier subfamily S member 2; Belongs to the potassium channel family. (477 aa) |
| | KCNJ2 | Inward rectifier potassium channel 2; Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be bl [...] (427 aa) |
| | KCNV1 | Potassium voltage-gated channel subfamily V member 1; Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes (By similarity); Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily. (502 aa) |
| | PDE4B | Phosphodiesterase. (721 aa) |
| | KCNK4 | Potassium two pore domain channel subfamily K member 4; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (404 aa) |
| | KCNH1 | Potassium voltage-gated channel subfamily H member 1; Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel. Channel properties are modulated by subunit assembly. Mediates IK(NI) current in myoblasts. Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow- derived mesenchymal stem cells (MSCs) (By similarity). (987 aa) |
| | KCNS1 | Potassium voltage-gated channel modifier subfamily S member 1; Belongs to the potassium channel family. (529 aa) |
| | EFCAB9 | EF-hand calcium binding domain 9. (218 aa) |
| | KCND1 | Potassium voltage-gated channel subfamily D member 1; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits (By similarity); Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.1/KCND1 sub-subfamily. (648 aa) |
| | PORCN | Porcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (450 aa) |
| | SMDT1 | Essential MCU regulator, mitochondrial; Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria. Required to bridge the calcium-sensing proteins MICU1 and MICU2 with the calcium-conducting subunit MCU. Plays a central role in regulating the uniplex complex response to intracellular calcium signaling. Acts by mediating activation of MCU and retention of MICU1 to the MCU pore, in order to ensure tight regulation of the uniplex complex and appropriate responses to intracellular calcium signaling; Belon [...] (107 aa) |
| | CACNA1G | Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2380 aa) |
| | CACNA1D | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa) |
| | TRPC5 | Short transient receptor potential channel 5; Belongs to the transient receptor (TC 1.A.4) family. (974 aa) |
| | CACNA1C | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2048 aa) |
| | HTR3A | 5-hydroxytryptamine receptor 3A; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (484 aa) |
| | CACNG2 | Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa) |
| | KCNMB2 | Potassium large conductance calcium-activated channel, subfamily M beta member 3. (235 aa) |
| | GRIN2C | Glutamate ionotropic receptor NMDA type subunit 2C. (1227 aa) |
| | TRPC2 | Short transient receptor potential channel 2 homolog; Thought to form a receptor-activated calcium permeant cation channel; Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC2 sub-subfamily. (1262 aa) |
| | GRIK2 | Glutamate ionotropic receptor kainate type subunit 2. (908 aa) |
| | KCNE3 | Potassium voltage-gated channel subfamily E regulatory subunit 3. (99 aa) |
| | SCNN1B | Amiloride-sensitive sodium channel subunit beta; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception; Belongs to the amiloride-sensit [...] (641 aa) |
| | CACNG5 | Calcium voltage-gated channel auxiliary subunit gamma 5. (325 aa) |
| | MCUB | Mitochondrial calcium uniporter dominant negative beta subunit. (335 aa) |
| | SCN4B | Sodium channel subunit beta-4; Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom (By similarity). (228 aa) |
| | KCNG2 | Potassium voltage-gated channel modifier subfamily G member 2; Belongs to the potassium channel family. (475 aa) |
| | AMIGO1 | Adhesion molecule with Ig like domain 1. (493 aa) |
| | CALM3 | Uncharacterized protein; Belongs to the calmodulin family. (149 aa) |
| | CATSPER1 | Cation channel sperm associated 1. (678 aa) |
| | CATSPER3 | Cation channel sperm associated 3. (400 aa) |
| | CACNA1A | Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2498 aa) |
| | KCNAB3 | Potassium voltage-gated channel, shaker-related subfamily, beta member 3. (404 aa) |
| | HCN2 | Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2. (903 aa) |
| | RYR2 | Ryanodine receptor 2. (4904 aa) |
| | UNC80 | Unc-80 homolog, NALCN channel complex subunit. (3258 aa) |
| | KCNA2 | Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family. (499 aa) |
| | KCNC3 | Potassium voltage-gated channel subfamily C member 3; Belongs to the potassium channel family. (774 aa) |
| | CACNA1F | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1972 aa) |
| | KCNA7 | Potassium voltage-gated channel subfamily A member 7; Belongs to the potassium channel family. (456 aa) |
| | KCNJ11 | Potassium inwardly-rectifying channel, subfamily J, member 11. (388 aa) |
| | CACHD1 | Cache domain containing 1. (1288 aa) |
| | SCN1A | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1998 aa) |
| | ABHD6 | Monoacylglycerol lipase ABHD6; Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (By similarity). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and [...] (337 aa) |
| | KCNA1 | Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa) |
| | KCNG4 | Potassium voltage-gated channel modifier subfamily G member 4; Belongs to the potassium channel family. (504 aa) |
| | HCN3 | Hyperpolarization activated cyclic nucleotide gated potassium channel 3. (783 aa) |
| | GRIK4 | Glutamate ionotropic receptor kainate type subunit 4. (957 aa) |
| | SCN11A | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1789 aa) |
| | HCN4 | Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1201 aa) |
| | SCNN1D | Sodium channel epithelial 1 delta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (651 aa) |
| | AKAP6 | A-kinase anchoring protein 6. (2319 aa) |
| | KCNV2 | Potassium voltage-gated channel modifier subfamily V member 2; Belongs to the potassium channel family. (566 aa) |
| | LRRC38 | Leucine rich repeat containing 38. (299 aa) |
| | STAC3 | SH3 and cysteine rich domain 3. (362 aa) |
| | GRIN3A | Glutamate ionotropic receptor NMDA type subunit 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1115 aa) |
| | CATSPERB | Cation channel sperm associated auxiliary subunit beta. (1081 aa) |
| | SCN3A | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1852 aa) |
| | CACNA2D1 | Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1103 aa) |
| | KCNQ3 | Potassium voltage-gated channel subfamily KQT member 3; Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. (866 aa) |
| | CNGA2 | Cyclic nucleotide-gated olfactory channel; Odorant signal transduction is probably mediated by a G- protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons; Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily. (663 aa) |
| | KCNA4 | Potassium voltage-gated channel subfamily A member 4; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium- selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well [...] (661 aa) |
| | KCNF1 | Potassium voltage-gated channel modifier subfamily F member 1; Belongs to the potassium channel family. (495 aa) |
| | CACNG6 | Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (261 aa) |
| | DPP6 | Dipeptidyl aminopeptidase-like protein 6; Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity. Belongs to the peptidase S9B family. (863 aa) |
| | CNGB1 | Cyclic nucleotide-gated cation channel beta-1; Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP (By similarity). (952 aa) |
| | PTPA | Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine- protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the var [...] (324 aa) |
| | TRPV6 | Transient receptor potential cation channel subfamily V member 6; Belongs to the transient receptor (TC 1.A.4) family. (721 aa) |
| | GRIN3B | Glutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1030 aa) |
| | KCNE2 | Potassium voltage-gated channel subfamily E regulatory subunit 2. (123 aa) |
| | SCN7A | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1550 aa) |
| | SESTD1 | SEC14 and spectrin domain containing 1. (696 aa) |
| | KCNB1 | Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa) |
| | MICU3 | Mitochondrial calcium uptake family member 3. (533 aa) |
| | GRIN2D | Glutamate ionotropic receptor NMDA type subunit 2D. (1333 aa) |
| | ABCC9 | ATP binding cassette subfamily C member 9. (1546 aa) |
| | KCNA10 | Potassium voltage-gated channel subfamily A member 10; Belongs to the potassium channel family. (511 aa) |
| | KCND3 | Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family. (655 aa) |
| | KCNAB2 | Voltage-gated potassium channel subunit beta-2; Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (By similarity). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). Promotes expression of the pore- forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (By similarity). Promotes KCNA4 channel closure (By similarit [...] (415 aa) |
| | KCND2 | Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (630 aa) |
| | CATSPER2 | Cation channel sperm associated 2. (529 aa) |
| | CACNA2D2 | Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1075 aa) |
| | KCNG3 | Potassium voltage-gated channel modifier subfamily G member 3; Belongs to the potassium channel family. (436 aa) |
| | KCNE5 | Potassium voltage-gated channel subfamily E regulatory subunit 5. (145 aa) |
| | ABCC8 | ATP binding cassette subfamily C member 8. (1584 aa) |
| | CACNA1B | Voltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2331 aa) |
| | TMEM249 | Transmembrane protein 249. (238 aa) |
| | KCNMA1 | Calcium-activated potassium channel subunit alpha-1; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the c [...] (1166 aa) |
| | CATSPERG | Cation channel sperm associated auxiliary subunit gamma. (791 aa) |
| | KCNMB1 | Calcium-activated potassium channel subunit beta-1; Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its prese [...] (191 aa) |
| | KCNB2 | Potassium voltage-gated channel subfamily B member 2; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric an [...] (911 aa) |
| | SCN8A | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1980 aa) |
| | SCN2A | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2006 aa) |
| | E1BME4_BOVIN | Uncharacterized protein. (550 aa) |
| | HCN1 | Hyperpolarization activated cyclic nucleotide gated potassium channel 1. (877 aa) |
| | TRPC6 | Short transient receptor potential channel 6; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily. (931 aa) |
| | VWC2 | Von Willebrand factor C domain containing 2. (326 aa) |
| | SHISA9 | Shisa family member 9. (245 aa) |
| | CNGB3 | Cyclic nucleotide gated channel subunit beta 3. (770 aa) |
| | SCN10A | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1976 aa) |
| | ABCB8 | ATP binding cassette subfamily B member 8. (825 aa) |
| | KCNAB1 | Voltage-gated potassium channel subunit beta-1; Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (By similarity). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (B [...] (408 aa) |
| | CATSPER4 | Cation channel sperm associated 4. (415 aa) |
| | HTR3B | 5-hydroxytryptamine receptor 3B; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (441 aa) |
| | KCNA6 | Potassium voltage-gated channel subfamily A member 6; Belongs to the potassium channel family. (528 aa) |
| | KCNQ5 | Potassium voltage-gated channel subfamily Q member 5; Belongs to the potassium channel family. (816 aa) |
| | LRRC26 | Leucine rich repeat containing 26. (326 aa) |
| | KCNA3 | Potassium voltage-gated channel subfamily A member 3; Belongs to the potassium channel family. (576 aa) |
| | GRIN1 | Glutamate ionotropic receptor NMDA type subunit 1. (356 aa) |
| | KCNC2 | Ion_trans domain-containing protein; Belongs to the potassium channel family. (240 aa) |
| | VWC2L | VWFC domain-containing protein. (222 aa) |
| | CACNG4 | Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (298 aa) |
| | KCNMB3 | Potassium calcium-activated channel subfamily M regulatory beta subunit 3. (283 aa) |
| | CCDC51 | Mitochondrial potassium channel; Mitochondrial potassium channel located in the mitochondrial inner membrane. Together with ABCB8/MITOSUR, forms a protein complex localized in the mitochondria that mediates ATP-dependent potassium currents across the inner membrane (that is, mitoK(ATP) channel). May contribute to the homeostatic control of cellular metabolism under stress conditions by regulating the mitochondrial matrix volume. (404 aa) |
| | GRIA3 | Glutamate ionotropic receptor AMPA type subunit 3. (894 aa) |
| | CALM2 | Uncharacterized protein; Belongs to the calmodulin family. (156 aa) |
| | FKBP1A-2 | Peptidyl-prolyl cis-trans isomerase FKBP1A; Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (108 aa) |
| | KCNH2 | Uncharacterized protein. (849 aa) |
| | GRIA1 | Glutamate ionotropic receptor AMPA type subunit 1. (906 aa) |
| | TRPC7 | Transient receptor potential cation channel subfamily C member 7; Belongs to the transient receptor (TC 1.A.4) family. (862 aa) |
| | SHISA8 | Shisa family member 8. (386 aa) |
| | KCNIP1 | Potassium voltage-gated channel interacting protein 1. (220 aa) |
| | AKAP9 | A-kinase anchoring protein 9. (3703 aa) |
| | FKBP1B | Peptidyl-prolyl cis-trans isomerase FKBP1B; Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity); Belongs to the FKBP-type PPIase family. FKBP1 subfamily. (174 aa) |
| | HSPA2 | Heat shock-related 70 kDa protein 2; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis [...] (636 aa) |
| | ENSBTAP00000062117 | Uncharacterized protein. (73 aa) |
| | CACNB3 | Voltage-dependent L-type calcium channel subunit beta-3; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation. Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). (550 aa) |
| | TMEM262 | Uncharacterized protein. (117 aa) |
| | ENSBTAP00000062540 | Uncharacterized protein. (230 aa) |
| | CNGA3 | Cyclic nucleotide-gated cation channel alpha-3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP [...] (706 aa) |
| | MICU2 | Mitochondrial calcium uptake 2. (435 aa) |
| | PKD2 | Polycystin-2; Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Can also form a functional, homotetrameric ion channel (By similarity). Functions as a cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Functions as outward-rectifying K(+) channel, but is also permeable to Ca(2+), and to a much lesser degree also to Na(+) (By similarity). May contribute to the release of Ca(2+) stores from the endoplasmic reticulum [...] (1033 aa) |
| | CACNA1E | Voltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2447 aa) |
| | SCNN1G | Amiloride-sensitive sodium channel subunit gamma; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. (652 aa) |
| | TRPC4 | Short transient receptor potential channel 4; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion. Acts as a cell-cell contact-dependent endothelial calcium entry channel (By similarity). (981 aa) |
| | KCNIP2 | Potassium voltage-gated channel interacting protein 2. (290 aa) |
| | CACNA2D3 | Calcium voltage-gated channel auxiliary subunit alpha2delta 3. (1091 aa) |
| | KCNC4 | Potassium voltage-gated channel subfamily C member 4; Belongs to the potassium channel family. (659 aa) |
| | KCNIP3 | Calsenilin; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity). (279 aa) |
| | CACNA2D4 | Calcium voltage-gated channel auxiliary subunit alpha2delta 4. (1101 aa) |
| | SCN3B | Sodium channel subunit beta-3; Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity). (215 aa) |
| | PDE4D | Phosphodiesterase. (678 aa) |
| | GRIN2A | Glutamate ionotropic receptor NMDA type subunit 2A. (1377 aa) |
| | CPT1C | Carnitine palmitoyltransferase 1C. (811 aa) |
| | ENSBTAP00000066836 | Uncharacterized protein. (99 aa) |
| | ENSBTAP00000067166 | Uncharacterized protein. (124 aa) |
| | OLFM3 | Olfactomedin 3. (478 aa) |
| | DLG3 | Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (849 aa) |
| | KCNQ2 | Potassium voltage-gated channel subfamily Q member 2; Belongs to the potassium channel family. (892 aa) |
| | CACNA1H | Calcium voltage-gated channel subunit alpha1 H. (2246 aa) |
| | ENSBTAP00000068368 | CaM_bdg_C0 domain-containing protein. (242 aa) |
| | TRPC3 | Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (920 aa) |
| | CACNB2 | Voltage-dependent L-type calcium channel subunit beta-2; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. (614 aa) |
| | CACNA1S | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2060 aa) |
| | SHISA7 | Shisa family member 7. (557 aa) |
| | GRIK3 | Glutamate ionotropic receptor kainate type subunit 3. (919 aa) |
| | FKBP1A | Peptidylprolyl isomerase. (128 aa) |
| | CACNA1I | Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2218 aa) |
| | PKD2L1 | Polycystin 2 like 1, transient receptor potential cation channel. (773 aa) |
| | KCNQ1 | Uncharacterized protein; Belongs to the potassium channel family. (670 aa) |
| | SCN2B | Uncharacterized protein. (215 aa) |
| | KCNIP4 | Kv channel-interacting protein 4; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents (By similarity); Belongs to the recoverin family. (250 aa) |
| | KCNQ4 | Potassium voltage-gated channel subfamily Q member 4; Belongs to the potassium channel family. (695 aa) |
| | KCNJ5 | G protein-activated inward rectifier potassium channel 4; This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating t [...] (419 aa) |
| | SHISA6 | Uncharacterized protein. (279 aa) |
| | GRIN2B | Glutamate ionotropic receptor NMDA type subunit 2B. (1497 aa) |
| | EPS8 | Epidermal growth factor receptor pathway substrate 8. (838 aa) |
| | KCNE1 | Potassium voltage-gated channel, Isk-related family, member 1. (129 aa) |
