STRINGSTRING
DZIP1 DZIP1 HAP1 HAP1 CCDC88A CCDC88A CCP110 CCP110 ENTR1 ENTR1 ARHGAP35 ARHGAP35 SEPTIN9 SEPTIN9 IFT88 IFT88 MARK4 MARK4 HTT HTT BBS4 BBS4 IFT20 IFT20 ATMIN ATMIN PPP1R35 PPP1R35 CEP135 CEP135 RP1 RP1 WRAP73 WRAP73 CENPJ CENPJ FUZ FUZ TAPT1 TAPT1 ZMYND10 ZMYND10 CROCC CROCC CEP120 CEP120 KCTD17 KCTD17 SAXO1 SAXO1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DZIP1DAZ interacting zinc finger protein 1. (911 aa)
HAP1Huntingtin associated protein 1. (620 aa)
CCDC88ACoiled-coil domain containing 88A. (1869 aa)
CCP110Centriolar coiled-coil protein 110. (1006 aa)
ENTR1Endosome-associated-trafficking regulator 1; Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis. Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27- retromer-dependent cargo proteins, such as GLUT1. Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1. Plays a role in the formation of cilia. Involved in cargo protein localization, such as PKD2, at primary cilia (By similarity). Involved in the presentation of the tumor necrosis factor (TNF) receptor TNFRSF1A on the cell surf [...] (432 aa)
ARHGAP35Rho GTPase activating protein 35. (1500 aa)
SEPTIN9Septin 9; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (585 aa)
IFT88Intraflagellar transport 88. (850 aa)
MARK4Non-specific serine/threonine protein kinase. (774 aa)
HTTHuntingtin. (3078 aa)
BBS4Bardet-Biedl syndrome 4 protein homolog; May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the [...] (519 aa)
IFT20Intraflagellar transport protein 20 homolog; Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Required for protein stability of E3 ubiquitin ligases CBL and CBLB that mediate ubiquitination and internalization of PDGFRA for proper feedback inhibition of PDGFRA signaling. Essential for male fertility. Plays an important role in spermatogenesis, particularly sperm [...] (156 aa)
ATMINATM interactor. (822 aa)
PPP1R35Protein phosphatase 1 regulatory subunit 35; Inhibits PPP1CA phosphatase activity. (266 aa)
CEP135Centrosomal protein 135. (1139 aa)
RP1Oxygen-regulated protein 1; Microtubule-associated protein regulating the stability and length of the microtubule-based axoneme of photoreceptors. Required for the differentiation of photoreceptor cells, it plays a role in the organization of the outer segment of rod and cone photoreceptors ensuring the correct orientation and higher-order stacking of outer segment disks along the photoreceptor axoneme (By similarity). (2105 aa)
WRAP73WD repeat containing, antisense to TP73. (458 aa)
CENPJCentromere protein J. (1354 aa)
FUZFuzzy planar cell polarity protein. (419 aa)
TAPT1Transmembrane anterior posterior transformation 1. (559 aa)
ZMYND10Zinc finger MYND domain-containing protein 10; Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins. Belongs to the ZMYND10 family. (439 aa)
CROCCCiliary rootlet coiled-coil, rootletin. (1984 aa)
CEP120Centrosomal protein of 120 kDa; Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. May play a role in centriole duplication during mitosis (By similarity). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK [...] (987 aa)
KCTD17Potassium channel tetramerization domain containing 17. (348 aa)
SAXO1Stabilizer of axonemal microtubules 1. (477 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.