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| | NOS2 | Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1156 aa) |
| | LOC540627 | Uncharacterized protein; Belongs to the cytochrome P450 family. (491 aa) |
| | PTGS1 | Prostaglandin G/H synthase 1; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells (By similarity). (635 aa) |
| | SUOX | Sulfite oxidase. (547 aa) |
| | CYCS | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | HEBP1 | Heme-binding protein 1; May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities (By similarity); Belongs to the HEBP family. (191 aa) |
| | IDO2 | Indoleamine 2,3-dioxygenase 2. (367 aa) |
| | G3X6I9_BOVIN | Uncharacterized protein; Belongs to the cytochrome P450 family. (413 aa) |
| | CYGB | Cytoglobin; Belongs to the globin family. (388 aa) |
| | CYP3A4 | Uncharacterized protein. (503 aa) |
| | MB | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles; Belongs to the globin family. (154 aa) |
| | LOC534967 | Uncharacterized protein. (1037 aa) |
| | G3MZ21_BOVIN | Uncharacterized protein. (141 aa) |
| | CYP2F1 | Cytochrome P450 family 2 subfamily F member 1; Belongs to the cytochrome P450 family. (473 aa) |
| | LOC540707 | Cytochrome P450 2A; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (450 aa) |
| | CYP21 | Steroid 21-hydroxylase; Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids. (496 aa) |
| | LPO | Lactoperoxidase; Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN). May protect the udder from infection and promote growth in newborn calves. Inhibits growth of the following bacterial species: E.coli, K.pneumoniae, P.aeruginosa, S.sonnei, S.saphrophyticus, S.epidermidis, and S.dysenteriae. Belongs to the peroxidase family. XPO subfamily. (731 aa) |
| | ADGB | Androglobin; Belongs to the peptidase C2 family. (1631 aa) |
| | GUCY1A2 | Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (730 aa) |
| | CYP1A1 | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (516 aa) |
| | CYTB | Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (379 aa) |
| | COX1 | Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (514 aa) |
| | HBE4 | Hemoglobin subunit epsilon-4; Hemoglobin epsilon chain is a beta-type chain found in early embryos; Belongs to the globin family. (147 aa) |
| | CYP2J2 | Uncharacterized protein; Belongs to the cytochrome P450 family. (502 aa) |
| | HBE1-2 | GLOBIN domain-containing protein; Belongs to the globin family. (150 aa) |
| | CYP27C1 | Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (537 aa) |
| | G5E6G2_BOVIN | Uncharacterized protein. (191 aa) |
| | HBM | Hemoglobin subunit mu; Belongs to the globin family. (141 aa) |
| | LOC100847700 | Cytochrome c. (105 aa) |
| | HBB | Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. (145 aa) |
| | CYP26C1 | Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (523 aa) |
| | HBE1 | GLOBIN domain-containing protein; Belongs to the globin family. (147 aa) |
| | CYP4A11 | Uncharacterized protein; Belongs to the cytochrome P450 family. (514 aa) |
| | F1MG97_BOVIN | Uncharacterized protein; Belongs to the cytochrome P450 family. (459 aa) |
| | CYP11B1 | Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] (503 aa) |
| | CYP8B1 | Cytochrome P450, family 8, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (166 aa) |
| | E1BAP8_BOVIN | GLOBIN domain-containing protein; Belongs to the globin family. (153 aa) |
| | HMOX2 | Heme oxygenase 2. (334 aa) |
| | SLC48A1 | Solute carrier family 48 member 1. (146 aa) |
| | HBG | Hemoglobin fetal subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. (145 aa) |
| | CYP2C18 | Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa) |
| | CUBN | Cubilin. (3620 aa) |
| | CYP24A1 | Uncharacterized protein. (447 aa) |
| | CYP2D14 | Cytochrome P450 2D14; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (500 aa) |
| | HBA | Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. (142 aa) |
| | LOC509506 | Uncharacterized protein; Belongs to the cytochrome P450 family. (528 aa) |
| | LOC785540 | Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa) |
| | C3H1orf194 | Chromosome 3 C1orf194 homolog. (170 aa) |
| | LOC511498 | Uncharacterized protein; Belongs to the cytochrome P450 family. (495 aa) |
| | CYP2C19 | CYP2C19 protein; Belongs to the cytochrome P450 family. (490 aa) |
| | CYCT | Cytochrome c 2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa) |
| | STEAP4 | STEAP4 metalloreductase. (470 aa) |
| | TCN2 | Transcobalamin-2; Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells; Belongs to the eukaryotic cobalamin transport proteins family. (432 aa) |
| | CYP26A1 | Uncharacterized protein; Belongs to the cytochrome P450 family. (497 aa) |
| | ABCB6 | ATP binding cassette subfamily B member 6. (843 aa) |
| | TCN1 | Transcobalamin 1. (427 aa) |
| | CYP2C87 | Uncharacterized protein; Belongs to the cytochrome P450 family. (492 aa) |
| | PGRMC1 | Membrane-associated progesterone receptor component 1; Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). (230 aa) |
| | FLVCR2 | MFS domain-containing protein. (558 aa) |
| | CYB561D2 | Cytochrome b561 domain-containing protein 2; Two-heme-containing cytochrome that catalyzes ascorbate- dependent trans-membrane ferric-chelate reduction. (222 aa) |
| | CYP2E1 | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. (509 aa) |
| | CYP2S1 | CYP2S1 protein; Belongs to the cytochrome P450 family. (494 aa) |
| | CYP2W1 | Cytochrome P450 family 2 subfamily W member 1; Belongs to the cytochrome P450 family. (493 aa) |
| | MMACHC | Methylmalonic aciduria and homocystinuria type C protein homolog; Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione- dependent reductive demethylation of adenosylcobalamin. Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen. Binds cyanocobalamin, adenosylcobalamin, methylcobalami [...] (280 aa) |
| | CYP27B1 | Uncharacterized protein; Belongs to the cytochrome P450 family. (508 aa) |
| | CYB561D1 | Cytochrome b561 family member D1. (231 aa) |
| | HBQ1 | Hemoglobin, theta 1; Belongs to the globin family. (142 aa) |
| | HBZ | GLOBIN domain-containing protein; Belongs to the globin family. (142 aa) |
| | HBA1 | GLOBIN domain-containing protein; Belongs to the globin family. (136 aa) |
| | LOC784417 | Uncharacterized protein; Belongs to the cytochrome P450 family. (521 aa) |
| | CYB5D2 | Cytochrome b5 domain containing 2; Belongs to the cytochrome b5 family. (263 aa) |
| | NGB | Neuroglobin; Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes (By similarity). (151 aa) |
| | SDHD | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (159 aa) |
| | DUOX1 | Dual oxidase 1. (1553 aa) |
| | DUOX2 | Dual oxidase 2. (1545 aa) |
| | LMBRD1 | Probable lysosomal cobalamin transporter; Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors (By similarity). (543 aa) |
| | B3GNT8 | Hexosyltransferase. (413 aa) |
| | FLVCR1 | MFS domain-containing protein. (556 aa) |
| | HEBP2 | Heme binding protein 2. (205 aa) |
| | MGC127055 | Uncharacterized protein MGC127055; Belongs to the cytochrome P450 family. (500 aa) |
| | LOC527083 | Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa) |
| | CYP20A1 | Cytochrome P450 20A1; Belongs to the cytochrome P450 family. (462 aa) |
| | HRG | Histidine-rich glycoprotein. (536 aa) |
| | STC2 | Stanniocalcin 2. (302 aa) |
| | CYP51A1 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] (502 aa) |
| | CYP4V2 | Uncharacterized protein; Belongs to the cytochrome P450 family. (527 aa) |
| | CBS | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (571 aa) |
| | NOS3 | Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets; Belongs to the NOS family. (1205 aa) |
| | CYP17A1 | Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family. (509 aa) |
| | CYP3A24 | Uncharacterized protein. (503 aa) |
| | CYP2J2-2 | Uncharacterized protein; Belongs to the cytochrome P450 family. (502 aa) |
| | HMOX1 | Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. (302 aa) |
| | TBXAS1 | Thromboxane-A synthase; Belongs to the cytochrome P450 family. (585 aa) |
| | CYP4F2 | Uncharacterized protein; Belongs to the cytochrome P450 family. (555 aa) |
| | MMUT | Methylmalonyl-CoA mutase, mitochondrial; Involved in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle; Belongs to the methylmalonyl-CoA mutase family. (750 aa) |
| | CYP2B6 | Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa) |
| | LOC782787 | Uncharacterized protein. (310 aa) |
| | PXDN | Peroxidasin. (1429 aa) |
| | PTGIS | Prostacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (517 aa) |
| | CYP1B1 | Uncharacterized protein; Belongs to the cytochrome P450 family. (539 aa) |
| | ENSBTAP00000057472 | Uncharacterized protein. (127 aa) |
| | DGCR8 | Microprocessor complex subunit DGCR8; Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that [...] (906 aa) |
| | IDO1 | Indoleamine 2,3-dioxygenase 1. (454 aa) |
| | PTGES2 | Prostaglandin E synthase 2 truncated form; Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2); Belongs to the GST superfamily. (431 aa) |
| | LOC107131172 | GLOBIN domain-containing protein; Belongs to the globin family. (145 aa) |
| | CYP3A5-2 | Cytochrome P450, family 3, subfamily A, polypeptide 5. (503 aa) |
| | LOC522146 | Uncharacterized protein; Belongs to the cytochrome P450 family. (491 aa) |
| | CAT | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells. (542 aa) |
| | LOC787671 | GLOBIN domain-containing protein; Belongs to the globin family. (140 aa) |
| | HCCS | Cytochrome c-type heme lyase; Links covalently the heme group to the apoprotein of cytochrome c. (275 aa) |
| | CYP4F2-2 | Uncharacterized protein; Belongs to the cytochrome P450 family. (524 aa) |
| | LOC100295883 | Uncharacterized protein; Belongs to the cytochrome P450 family. (529 aa) |
| | CYP2R1 | Uncharacterized protein; Belongs to the cytochrome P450 family. (471 aa) |
| | RSAD1 | Radical S-adenosyl methionine domain-containing protein 1, mitochondrial; May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen- III oxidase activity (By similarity). Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl- L-methionine (By similarity). (477 aa) |
| | CYB5B | Cytochrome b5 type B; Belongs to the cytochrome b5 family. (146 aa) |
| | MPO | Myeloperoxidase. (719 aa) |
| | LOC112444495 | Steroid 17-alpha-hydroxylase/17,20 lyase. (509 aa) |
| | LOC530571 | Uncharacterized protein; Belongs to the cytochrome P450 family. (498 aa) |
| | ENSBTAP00000068484 | GLOBIN domain-containing protein; Belongs to the globin family. (88 aa) |
| | CYP7B1 | Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (446 aa) |
| | MTR | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). (1265 aa) |
| | CYB5A | Cytochrome b5; Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases. (134 aa) |
| | ENSBTAP00000067553 | Uncharacterized protein. (191 aa) |
| | FADS1 | Fatty acid desaturase 1. (474 aa) |
| | CYB5R4 | Cytochrome b5 reductase 4; NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS) (By similarity); Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (520 aa) |
| | TDO2 | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (418 aa) |
| | CYBA | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide; Belongs to the p22phox family. (191 aa) |
| | TPO | Thyroid peroxidase. (903 aa) |
| | NOS1 | Nitric oxide synthase; Produces nitric oxide (NO). (1359 aa) |
| | NR1D1 | Nuclear receptor subfamily 1 group D member 1; Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARTNL/BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for [...] (630 aa) |
| | CYP46A1 | Cytochrome P450, family 46, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. (501 aa) |
| | GUCY1A1 | Guanylate cyclase soluble subunit alpha-1. (691 aa) |
| | LOC521656 | Uncharacterized protein; Belongs to the cytochrome P450 family. (502 aa) |
| | ENSBTAP00000064434 | Uncharacterized protein. (370 aa) |
| | SDHC | Succinate dehydrogenase cytochrome b560 subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the cytochrome b560 family. (169 aa) |
| | CYP4X1 | Cytochrome P450 family 4 subfamily X member 1; Belongs to the cytochrome P450 family. (471 aa) |
| | CYP19A1 | Aromatase; A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19- aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19 [...] (503 aa) |
| | LOC112441470 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] (509 aa) |
| | PTGS2 | Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (604 aa) |
| | LOC107132327 | Uncharacterized protein; Belongs to the cytochrome P450 family. (502 aa) |
| | CYP27A1 | Uncharacterized protein; Belongs to the cytochrome P450 family. (537 aa) |
| | THAP4 | THAP domain-containing protein 4. (570 aa) |
| | CYP2U1 | Cytochrome P450 2U1; A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. May downregulate [...] (543 aa) |
| | CYBB | Cytochrome b-245 heavy chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. (805 aa) |
| | CYC1 | Cytochrome c1, heme protein, mitochondrial; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient ove [...] (325 aa) |
| | CYP26B1 | Cytochrome P450 26B1; Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13- cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Essential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required [...] (512 aa) |
| | CYP3A5 | Cytochrome P450 3A28; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (507 aa) |
| | CBLIF | Cobalamin binding intrinsic factor. (417 aa) |
| | CYP4B1 | Cytochrome P450, family 4, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (511 aa) |
| | PGRMC2 | Progesterone receptor membrane component 2; Belongs to the cytochrome b5 family. (247 aa) |
| | LOC505468 | Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa) |
| | CYP7A1 | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (500 aa) |
| | MMAB | Corrinoid adenosyltransferase; Adenosyltransferase involved in intracellular vitamin B12 metabolism. Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer taht is stimulated by ATP-binding to MMAB and gated by MMAA. (241 aa) |
| | LOC112449566 | Uncharacterized protein; Belongs to the cytochrome P450 family. (457 aa) |
| | HBE2 | Hemoglobin subunit epsilon-2; Hemoglobin epsilon chain is a beta-type chain found in early embryos; Belongs to the globin family. (147 aa) |
| | GUCY1B1 | Guanylate cyclase soluble subunit beta-1; Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (619 aa) |
| | CYP39A1 | CYP39A1 protein; Belongs to the cytochrome P450 family. (469 aa) |
| | CYP1A2 | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (516 aa) |
| | CYP4A22 | CYP4A22 protein; Belongs to the cytochrome P450 family. (515 aa) |
| | SRC | Tyrosine-protein kinase. (688 aa) |
| | LOC112449027 | Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (741 aa) |
| | EIF2AK1 | Eukaryotic translation initiation factor 2 alpha kinase 1. (632 aa) |
| | CYP11A1 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (520 aa) |
