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P4HA1 P4HA1 GPI GPI COLEC10 COLEC10 G6PD G6PD EGLN1 EGLN1 PFKM PFKM ENSBTAP00000065364 ENSBTAP00000065364 CLEC4A CLEC4A PYGL PYGL HK1 HK1 HK3 HK3 CLEC17A CLEC17A EGLN2 EGLN2 ALDOA ALDOA P4HA2 P4HA2 ALDOB ALDOB ALPK1 ALPK1 HK2 HK2 CLEC4D CLEC4D PFKL PFKL MRC1 MRC1 ENG ENG DBH DBH LOC107131287 LOC107131287 HKDC1 HKDC1 GCK GCK SLC2A3 SLC2A3 BSG BSG P3H3 P3H3 IGF2R IGF2R OGFOD1 OGFOD1 CLEC6A CLEC6A PLOD2 PLOD2 LMAN1L LMAN1L P3H2 P3H2 SELP SELP CLN5 CLN5 OGFOD3 OGFOD3 P3H1 P3H1 COLEC11 COLEC11 GALK1 GALK1 CL46 CL46 CLEC4G CLEC4G PAM PAM FBP1 FBP1 EGLN3 EGLN3 LMAN2 LMAN2 PHYH PHYH SLC2A5 SLC2A5 MBL2 MBL2 SLC2A8 SLC2A8 LMAN1 LMAN1 P4HA3 P4HA3 FUOM FUOM P4HTM P4HTM GNPNAT1 GNPNAT1 LMAN2L LMAN2L CGN1 CGN1 PFKP PFKP PLOD1 PLOD1 OGFOD2 OGFOD2 PLOD3 PLOD3 MBL1 MBL1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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P4HA1Prolyl 4-hydroxylase subunit alpha-1; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family. (534 aa)
GPIGlucose-6-phosphate isomerase; In the cytoplasm, catalyzes the conversion of glucose-6- phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (By similarity). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity). (565 aa)
COLEC10C-type lectin domain-containing protein. (277 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (555 aa)
EGLN1Uncharacterized protein. (420 aa)
PFKMATP-dependent 6-phosphofructokinase, muscle type; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (850 aa)
ENSBTAP00000065364MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (467 aa)
CLEC4AC-type lectin domain family 4 member A. (237 aa)
PYGLGlycogen phosphorylase, liver form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity). (859 aa)
HK1Hexokinase-1; Catalyzes the phosphorylation of various hexoses, such as D- glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6- phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor f [...] (995 aa)
HK3Hexokinase 3. (924 aa)
CLEC17AUncharacterized protein. (273 aa)
EGLN2Fe2OG dioxygenase domain-containing protein. (415 aa)
ALDOAFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (365 aa)
P4HA2Prolyl 4-hydroxylase subunit alpha 2. (535 aa)
ALDOBFructose-bisphosphate aldolase B. (420 aa)
ALPK1Alpha kinase 1. (1242 aa)
HK2Hexokinase 2. (917 aa)
CLEC4DC-type lectin domain family 4 member D. (213 aa)
PFKLATP-dependent 6-phosphofructokinase, liver type; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (By similarity). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity). Belongs to the phosphofructokinase typ [...] (780 aa)
MRC1Mannose receptor C-type 1. (1441 aa)
ENGZP domain-containing protein. (650 aa)
DBHSoluble dopamine beta-hydroxylase; Conversion of dopamine to noradrenaline. Belongs to the copper type II ascorbate-dependent monooxygenase family. (621 aa)
LOC107131287Solute carrier family 2, facilitated glucose transporter member 5. (501 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
GCKPhosphotransferase. (465 aa)
SLC2A3Solute carrier family 2, facilitated glucose transporter member 3; Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. (494 aa)
BSGBasigin. (320 aa)
P3H3Prolyl 3-hydroxylase 3. (725 aa)
IGF2RCation-independent mannose-6-phosphate receptor; Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2; Belongs to the MRL1/IGF2R family. (2499 aa)
OGFOD1Prolyl 3-hydroxylase OGFOD1; Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro- 62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation; Belongs to the TPA1 family. (542 aa)
CLEC6AC-type lectin domain family 6 member A; Binds high-mannose carbohydrates in a Ca(2+)-dependent manner (By similarity). Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G a [...] (206 aa)
PLOD2Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2. (762 aa)
LMAN1LLectin, mannose binding 1 like. (504 aa)
P3H2Prolyl 3-hydroxylase 2. (706 aa)
SELPP-selectin; Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG (By similarity). Belongs to the selectin/LECAM family. (646 aa)
CLN5Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family. (358 aa)
OGFOD32-oxoglutarate and iron dependent oxygenase domain containing 3. (315 aa)
P3H1Prolyl 3-hydroxylase 1. (736 aa)
COLEC11Collectin-11; Lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope. Primarily recognizes the terminal disaccharide of the glycan. Also recognizes a subset of fucosylated glycans and lipopolysaccharides. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1. Also plays a role in apoptosis [...] (267 aa)
GALK1Galactokinase; Major enzyme for galactose metabolism; Belongs to the GHMP kinase family. GalK subfamily. (392 aa)
CL46Collectin-46; Belongs to the SFTPD family. (371 aa)
CLEC4GC-type lectin domain family 4 member G. (290 aa)
PAMPeptidyl-alpha-hydroxyglycine alpha-amidating lyase; Bifunctional enzyme that catalyzes the post-translational modification of inactive peptidylglycine precursors to the corresponding bioactive alpha-amidated peptides, a terminal modification in biosynthesis of many neural and endocrine peptides. Alpha-amidation involves two sequential reactions, both of which are catalyzed by separate catalytic domains of the enzyme. The first step, catalyzed by peptidyl alpha-hydroxylating monoxygenase (PHM) domain, is the copper-, ascorbate-, and O2- dependent stereospecific hydroxylation (with S st [...] (972 aa)
FBP1Fructose-1,6-bisphosphatase 1; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism [...] (338 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (239 aa)
LMAN2Lectin, mannose binding 2. (359 aa)
PHYHPhytanoyl-CoA dioxygenase, peroxisomal; Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA. (337 aa)
SLC2A5Solute carrier family 2, facilitated glucose transporter member 5; Functions as a fructose transporter that has only low activity with other monosaccharides. Can mediate the uptake of deoxyglucose, but with low efficiency. Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake. (501 aa)
MBL2Mannose-binding protein C; Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity). (249 aa)
SLC2A8Solute carrier family 2, facilitated glucose transporter member 8; Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose. Also able to mediate the transport of dehydroascorbate. (478 aa)
LMAN1Lectin, mannose binding 1. (518 aa)
P4HA3Prolyl 4-hydroxylase subunit alpha-3; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. (544 aa)
FUOMFucose mutarotase; Involved in the interconversion between alpha- and beta-L- fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition proces [...] (154 aa)
P4HTMProlyl 4-hydroxylase, transmembrane. (494 aa)
GNPNAT1Glucosamine 6-phosphate N-acetyltransferase. (184 aa)
LMAN2LVIP36-like protein; May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53 (By similarity). (359 aa)
CGN1Conglutinin; Calcium-dependent lectin-like protein which binds to a yeast cell wall extract and immune complexes through the complement component (C3bi). It is capable of binding non-reducing terminal N- acetylglucosamine, mannose, and fucose residues. (371 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (960 aa)
PLOD1Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1; Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys- Gly- sequences in collagens (By similarity). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (By similarity). (726 aa)
OGFOD22-oxoglutarate and iron dependent oxygenase domain containing 2. (350 aa)
PLOD3Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3. (751 aa)
MBL1Liver mannan-binding lectin. (248 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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