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| | VPS51 | Vacuolar protein sorting-associated protein 51 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome- derived carriers to the TGN. Acts as component of the EARP complex [...] (781 aa) |
| | AMN | Amnion associated transmembrane protein. (462 aa) |
| | ATP9A | Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1054 aa) |
| | AP3S1 | AP-3 complex subunit sigma-1; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity). (193 aa) |
| | VAMP5 | Vesicle-associated membrane protein 5; May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking. Belongs to the synaptobrevin family. (165 aa) |
| | RAB1B | Ras-related protein Rab-1B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (By similarity). Regulates [...] (296 aa) |
| | ARFGAP2 | ADP-ribosylation factor GTPase-activating protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity). (534 aa) |
| | KLHL12 | Kelch-like protein 12; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts w [...] (568 aa) |
| | YIF1B | Yip1 interacting factor homolog B, membrane trafficking protein. (312 aa) |
| | GOLGA7 | Golgin subfamily A member 7; May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS (By similarity); Belongs to the ERF4 family. (137 aa) |
| | GOLPH3 | Golgi phosphoprotein 3 (Coat-protein). (298 aa) |
| | SNX2 | Sorting nexin-2; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called en [...] (519 aa) |
| | BBS2 | Bardet-Biedl syndrome 2 protein homolog. (721 aa) |
| | SPIRE1 | Spire type actin nucleation factor 1. (737 aa) |
| | CUL3 | Cullin 3; Belongs to the cullin family. (768 aa) |
| | LMAN1L | Lectin, mannose binding 1 like. (504 aa) |
| | SAR1B | GTP-binding protein SAR1b; Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex (By similarity). (198 aa) |
| | EXOC6 | Exocyst complex component; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (803 aa) |
| | BCAP31 | B-cell receptor-associated protein 31. (245 aa) |
| | SEC31A | SEC31 homolog A, COPII coat complex component. (1266 aa) |
| | STX6 | STX6 protein; Belongs to the syntaxin family. (255 aa) |
| | PGAP1 | GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI- anchored proteins from the endoplasmic reticulum to the Golgi. (922 aa) |
| | GOLPH3L | Golgi phosphoprotein 3-like; Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane. (285 aa) |
| | COG2 | Component of oligomeric golgi complex 2. (739 aa) |
| | BBS1 | BBS1 domain-containing protein. (667 aa) |
| | ZW10 | ZW10, kinetochore associated, homolog (Drosophila). (779 aa) |
| | COMMD1 | COMM domain-containing protein 1; Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2. Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF- kappa-B activity. Involved in the regulation of membrane expression and ubiquiti [...] (188 aa) |
| | CNIH4 | Protein cornichon homolog 4; Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery. (139 aa) |
| | DOP1A | DOP1 leucine zipper like protein A. (2485 aa) |
| | VTI1A | Vesicle transport through interaction with t-SNAREs 1A. (224 aa) |
| | COPZ2 | Coatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. (210 aa) |
| | SCAP | Sterol regulatory element-binding protein cleavage-activating protein; Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, prot [...] (1278 aa) |
| | MIA2 | SH3 domain-containing protein. (1381 aa) |
| | TMED3 | Transmembrane p24 trafficking protein 3. (254 aa) |
| | ARFGEF2 | ADP ribosylation factor guanine nucleotide exchange factor 2. (1779 aa) |
| | RNF215 | Ring finger protein 215. (521 aa) |
| | RAB1A | RAB1A, member RAS oncogene family. (221 aa) |
| | NSF | N-ethylmaleimide sensitive factor, vesicle fusing ATPase. (771 aa) |
| | ARFGAP3 | ADP-ribosylation factor GTPase-activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity). (524 aa) |
| | GGA3 | Golgi associated, gamma adaptin ear containing, ARF binding protein 3. (753 aa) |
| | VAPA | Vesicle-associated membrane protein-associated protein A; Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking. (325 aa) |
| | FBXW7 | F-box/WD repeat-containing protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (By similarity). Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. Acts as a negative regulator of JNK si [...] (706 aa) |
| | RBSN | Rabenosyn, RAB effector. (783 aa) |
| | DYNLT1 | Dynein light chain Tctex-type 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. May also be a accessory component of axonemal dynein (By similarity). (113 aa) |
| | COG8 | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. (626 aa) |
| | YIPF6 | Protein YIPF6; May be required for stable YIPF1 and YIPF2 protein expression. (236 aa) |
| | SNX1 | Sorting nexin-1; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called en [...] (522 aa) |
| | E1BE23_BOVIN | GOLD domain-containing protein. (215 aa) |
| | GGA2 | Golgi associated, gamma adaptin ear containing, ARF binding protein 2. (616 aa) |
| | TICAM2 | TIR domain-containing adapter molecule 2; Functions as sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction. In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement. Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adapt [...] (232 aa) |
| | VPS52 | VPS52 subunit of GARP complex. (723 aa) |
| | SEC24C | SEC24 homolog C, COPII coat complex component. (1117 aa) |
| | AP4M1 | AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asym [...] (460 aa) |
| | RAB33B | RAB33B, member RAS oncogene family. (229 aa) |
| | TFG | TFG protein. (401 aa) |
| | STEAP2 | Six transmembrane epithelial antigen of the prostate 2. (490 aa) |
| | SEC24D | SEC24 homolog D, COPII coat complex component. (1032 aa) |
| | SEC23A | Protein transport protein Sec23A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (765 aa) |
| | AP1AR | Adaptor related protein complex 1 associated regulatory protein. (302 aa) |
| | LMAN2L | VIP36-like protein; May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53 (By similarity). (359 aa) |
| | TRAPPC5 | Trafficking protein particle complex subunit 5; May play a role in vesicular transport from endoplasmic reticulum to Golgi. (188 aa) |
| | ARL3 | ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliar [...] (198 aa) |
| | COPA | Coatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also inf [...] (1224 aa) |
| | KDELR1 | ER lumen protein-retaining receptor 1; Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum. Belongs to the ERD2 family. (212 aa) |
| | GOLGA5 | GOLGA5 protein. (732 aa) |
| | YIF1A | Protein YIF1A; Possible role in transport between endoplasmic reticulum and Golgi. (293 aa) |
| | GOSR1 | Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an import [...] (250 aa) |
| | C18H16orf70 | Chromosome 18 C16orf70 homolog. (449 aa) |
| | SYS1 | Protein SYS1 homolog; Involved in protein trafficking. May serve as a receptor for ARFRP1 (By similarity). (156 aa) |
| | TRAPPC10 | Foie-gras_1 domain-containing protein. (1259 aa) |
| | RAB34 | Uncharacterized protein. (332 aa) |
| | TRAPPC8 | Trafficking protein particle complex 8. (1434 aa) |
| | NPRL2 | GATOR complex protein NPRL2; As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway; Belongs to the NPR2 family. (433 aa) |
| | COPZ1 | Coatomer subunit zeta-1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-disso [...] (177 aa) |
| | TMED10 | Transmembrane emp24 domain-containing protein 10; Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft [...] (219 aa) |
| | HYOU1 | Hypoxia up-regulated 1. (1021 aa) |
| | WIPI1 | WD repeat domain, phosphoinositide interacting 1. (504 aa) |
| | BLZF1 | Basic leucine zipper nuclear factor 1. (402 aa) |
| | SLC10A7 | Sodium/bile acid cotransporter; Does not show transport activity towards bile acids or steroid sulfates; Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. (340 aa) |
| | RINT1 | RAD50 interactor 1. (792 aa) |
| | TRIP11 | Thyroid hormone receptor interactor 11. (1976 aa) |
| | TMED2 | GOLD domain-containing protein. (208 aa) |
| | NBAS | Uncharacterized protein. (2149 aa) |
| | RAB31 | RAB31, member RAS oncogene family. (195 aa) |
| | EXOC1 | Exocyst complex component 1. (919 aa) |
| | SNX12 | Sorting nexin 12. (164 aa) |
| | SEC22B | SEC22 homolog B, vesicle trafficking protein; Belongs to the synaptobrevin family. (277 aa) |
| | ANKFY1 | Ankyrin repeat and FYVE domain containing 1. (1186 aa) |
| | STX18 | STX18 protein. (335 aa) |
| | COG1 | Component of oligomeric golgi complex 1. (981 aa) |
| | EXOC8 | Exocyst complex component 8; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (725 aa) |
| | GGA1 | Golgi associated, gamma adaptin ear containing, ARF binding protein 1. (684 aa) |
| | MYO5A | Myosin VA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1882 aa) |
| | GABARAPL2 | Gamma-aminobutyric acid receptor-associated protein-like 2; Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved [...] (117 aa) |
| | COPB1 | Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also infl [...] (953 aa) |
| | SEC22C | Vesicle-trafficking protein SEC22c; May be involved in vesicle transport between the ER and the Golgi complex; Belongs to the synaptobrevin family. (303 aa) |
| | ERGIC3 | Endoplasmic reticulum-Golgi intermediate compartment protein 3; Possible role in transport between endoplasmic reticulum and Golgi; Belongs to the ERGIC family. (383 aa) |
| | ARCN1 | Coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also inf [...] (511 aa) |
| | LMAN1 | Lectin, mannose binding 1. (518 aa) |
| | SPTBN1 | Spectrin beta chain; Belongs to the spectrin family. (2363 aa) |
| | TRAPPC6A | Trafficking protein particle complex subunit 6A; May play a role in vesicular transport during the biogenesis of melanosomes. (159 aa) |
| | TRAPPC11 | Trafficking protein particle complex subunit 11; Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. (1133 aa) |
| | SEC23IP | SEC23 interacting protein. (1006 aa) |
| | RAB6A | Uncharacterized protein. (208 aa) |
| | SEC31B | SEC31 homolog B, COPII coat complex component. (1177 aa) |
| | VPS54 | VPS54 subunit of GARP complex. (977 aa) |
| | YKT6 | Synaptobrevin homolog YKT6; Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity; Belongs to the synaptobrevin family. (198 aa) |
| | RAB26 | Ras-related protein Rab-26; Participates in exocrine secretion: regulates the secretion of acinar granules in the parotid gland; Belongs to the small GTPase superfamily. Rab family. (256 aa) |
| | COPE | Coatomer subunit epsilon; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex [...] (308 aa) |
| | BNIP1 | BCL2 interacting protein 1. (320 aa) |
| | TMED5 | Transmembrane emp24 domain-containing protein 5; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport (By similarity). (234 aa) |
| | SEC16B | Protein transport protein Sec16B; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes. (1035 aa) |
| | CCDC22 | Coiled-coil domain-containing protein 22; Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10. Component of the CCC complex, which is inv [...] (627 aa) |
| | ARF3 | ADP-ribosylation factor 3; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity). (181 aa) |
| | AP1G1 | AP-1 complex subunit gamma. (825 aa) |
| | CYTH3 | Cytohesin 3. (418 aa) |
| | VAMP7 | Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocy [...] (152 aa) |
| | LOC509184 | GOLD domain-containing protein. (229 aa) |
| | TBC1D14 | TBC1 domain family member 14; Plays a role in the regulation of starvation-induced autophagosome formation. Together with the TRAPPIII complex, regulates a constitutive trafficking step from peripheral recycling endosomes to the early Golgi, maintaining the cycling pool of ATG9 required for initiation of autophagy. (692 aa) |
| | MIA3 | Transport and Golgi organization protein 1 homolog; Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein s [...] (1929 aa) |
| | PRKD1 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa) |
| | COPB2 | Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also infl [...] (906 aa) |
| | STXBP6 | Syntaxin-binding protein 6; Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis. (220 aa) |
| | ENSBTAP00000068879 | Dopey_N domain-containing protein. (209 aa) |
| | SORT1 | Sortilin. (909 aa) |
| | TRAPPC12 | Trafficking protein particle complex 12. (794 aa) |
| | GOSR2 | Uncharacterized protein; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. (213 aa) |
| | GOLT1A | Vesicle transport protein GOT1A; May be involved in fusion of ER-derived transport vesicles with the Golgi complex; Belongs to the GOT1 family. (179 aa) |
| | PDCD6 | Programmed cell death 6. (191 aa) |
| | CUX1 | Homeobox protein cut-like. (1648 aa) |
| | BET1 | Bet1 golgi vesicular membrane trafficking protein. (134 aa) |
| | SGSM2 | Small G protein signaling modulator 2. (1049 aa) |
| | GOLGA4 | Golgin A4. (2303 aa) |
| | KLHL20 | Kelch-like protein 20; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination. Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting inte [...] (662 aa) |
| | AP3D1 | AP-3 complex subunit delta-1; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T- cell and NK cell degranulation. In concert with the BLOC-1 complex, AP- 3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. Belongs to the adaptor complexes large subunit [...] (1224 aa) |
| | ENSBTAP00000071770 | Uncharacterized protein. (229 aa) |
| | TEX261 | Protein TEX261. (238 aa) |
| | MPPE1 | Metallophosphoesterase 1. (399 aa) |
| | PREPL | Prolyl endopeptidase like. (727 aa) |
| | RAB13 | Ras-related protein Rab-13; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regu [...] (203 aa) |
| | WHAMM | WASP homolog associated with actin, golgi membranes and microtubules. (274 aa) |
| | RAB14 | RAB14, member RAS oncogene family. (215 aa) |
| | SEC13 | Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles. Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum; Belongs to the WD repeat SEC13 family. (322 aa) |
| | COG3 | Component of oligomeric golgi complex 3. (831 aa) |
| | CLN3 | Battenin. (438 aa) |
| | NRBP1 | Nuclear receptor binding protein 1. (535 aa) |
| | SEC23B | Protein transport protein Sec23B; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. (770 aa) |
| | SNX3 | Sorting nexin-3; Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo- selective subcomplex (CSC). May act in part as component of the SNX3- retromer complex which mediates the retrograde [...] (162 aa) |
| | RANGRF | Ran guanine nucleotide release factor; May regulate the intracellular trafficking of RAN. Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1. Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics. Enhances the expression of SCN5A at the cell membrane in cardiomyocytes. (186 aa) |
| | TRAPPC2L | Trafficking protein particle complex subunit 2-like protein; May play a role in vesicular transport from endoplasmic reticulum to Golgi. (139 aa) |
| | GAK | Cyclin G associated kinase. (1268 aa) |
| | COPG2 | Coatomer subunit gamma-2; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also i [...] (871 aa) |
| | USO1 | General vesicular transport factor p115; General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. (961 aa) |
| | SAR1A | GTP-binding protein SAR1a; Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES) (By similarity). (198 aa) |
| | COG6 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. (657 aa) |
| | OPTN | Optineurin. (573 aa) |
| | DGAT2 | UV radiation resistance associated. (699 aa) |
| | STX10 | Syntaxin 10. (249 aa) |
| | RAB8A | Ras-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...] (207 aa) |
| | GCC2 | GRIP and coiled-coil domain containing 2. (1684 aa) |
| | ERGIC1 | Endoplasmic reticulum-golgi intermediate compartment 1. (290 aa) |
| | CREB3L2 | cAMP responsive element binding protein 3 like 2. (520 aa) |
| | RAB6B | Ras-related protein Rab-6B; Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (By similarity). (208 aa) |
| | SPIRE2 | Spire type actin nucleation factor 2. (729 aa) |
| | TMED9 | Transmembrane emp24 domain-containing protein 9; Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of t [...] (235 aa) |
| | AP3S2 | AP-3 complex subunit sigma-2; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity). (193 aa) |
| | HTT | Huntingtin. (3078 aa) |
| | KRT18 | Keratin 18; Belongs to the intermediate filament family. (429 aa) |
| | YIPF7 | Protein YIPF7. (255 aa) |
| | SEC16A | Protein transport protein sec16; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. (2328 aa) |
| | SEC24A | Protein transport protein Sec24A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Plays a central role in cargo selection within the COPII complex and together with SEC24B may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may [...] (1099 aa) |
| | LLGL1 | Lethal(2) giant larvae protein homolog 1; Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane (By similarity); Belongs to the WD repeat L(2)GL family. (1153 aa) |
| | EHD3 | EH domain containing 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (535 aa) |
| | LAMP1 | Lysosome-associated membrane glycoprotein 1; Belongs to the LAMP family. (409 aa) |
| | SCYL1 | N-terminal kinase-like protein; Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the Golgi apparatus morphology. Has no detectable kinase activity in vitro. (807 aa) |
| | COG7 | Conserved oligomeric Golgi complex subunit 7; Required for normal Golgi function. (770 aa) |
| | SCFD1 | Sec1 family domain containing 1; Belongs to the STXBP/unc-18/SEC1 family. (705 aa) |
| | STX5 | Syntaxin-5; Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter- connected structure of the Golgi apparatus. (355 aa) |
| | IER3IP1 | Immediate early response 3-interacting protein 1; May be implicated in the regulation of apoptosis. May be involved in protein transport between endoplasmic reticulum and Golgi apparatus; Belongs to the YOS1 family. (82 aa) |
| | SPAST | Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] (614 aa) |
| | EXOC6B | Exocyst complex component; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (766 aa) |
| | TRAPPC3L | Trafficking protein particle complex subunit; May play a role in vesicular transport from endoplasmic reticulum to Golgi. (181 aa) |
| | NKD2 | NKD inhibitor of WNT signaling pathway 2. (405 aa) |
| | SEC24B | SEC24 homolog B, COPII coat complex component. (1459 aa) |
| | F1N380_BOVIN | Clat_adaptor_s domain-containing protein. (188 aa) |
| | RP2 | Protein XRP2; Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. (350 aa) |
| | TMED7 | Transmembrane p24 trafficking protein 7. (225 aa) |
| | G5E666_BOVIN | GOLD domain-containing protein. (201 aa) |
| | PITPNB | Phosphatidylinositol transfer protein beta isoform; Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes. (271 aa) |
| | AP1G2 | AP-1 complex subunit gamma. (884 aa) |
| | ENSBTAP00000051699 | Uncharacterized protein. (82 aa) |
| | EPS15 | Epidermal growth factor receptor pathway substrate 15. (910 aa) |
| | EXOC1L | Exocyst complex component 1 like. (172 aa) |
| | CXHXorf56 | UPF0428 protein CXorf56 homolog. (222 aa) |
| | G3N0F2_BOVIN | PB1 domain-containing protein. (347 aa) |
| | TRAPPC1 | Trafficking protein particle complex subunit 1; May play a role in vesicular transport from endoplasmic reticulum to Golgi. (145 aa) |
| | COG5 | Conserved oligomeric Golgi complex subunit 5. (678 aa) |
| | BICD2 | BICD cargo adaptor 2. (805 aa) |
| | GOLT1B | Vesicle transport protein GOT1B; May be involved in fusion of ER-derived transport vesicles with the Golgi complex; Belongs to the GOT1 family. (140 aa) |
| | TRAPPC3 | Trafficking protein particle complex subunit; May play a role in vesicular transport from endoplasmic reticulum to Golgi. (180 aa) |
| | VTI1B | Vesicle transport through interaction with t-SNAREs homolog 1B; V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence. (281 aa) |
| | COG5-2 | COG5 protein. (199 aa) |
| | EXOC2 | Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (924 aa) |
| | ENSBTAP00000057338 | Uncharacterized protein. (108 aa) |
| | ARFRP1 | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. (201 aa) |
| | TMED6 | Transmembrane emp24 domain-containing protein 6. (240 aa) |
| | ATP9B | Probable phospholipid-transporting ATPase IIB; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1136 aa) |
| | STX17 | Syntaxin-17; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate [...] (302 aa) |
| | LMAN2 | Lectin, mannose binding 2. (359 aa) |
| | TRAPPC4 | Trafficking protein particle complex subunit 4; May play a role in vesicular transport from endoplasmic reticulum to Golgi. (219 aa) |
| | NRBP2 | Nuclear receptor binding protein 2. (499 aa) |
| | YIPF4 | Protein YIPF. (244 aa) |
| | DNAJC28 | DnaJ heat shock protein family (Hsp40) member C28. (380 aa) |
| | CORO7 | Coronin-7; F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology (By similarity). (979 aa) |
| | KDELR2 | ER lumen protein-retaining receptor 2; Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum (By similarity). Binding is pH dependent, and is optimal at pH 5-5.4 (By similarity). (212 aa) |
| | RER1 | Protein RER1; Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment; Belongs to the RER1 family. (196 aa) |
| | ARF5 | ADP ribosylation factor 5; Belongs to the small GTPase superfamily. Arf family. (180 aa) |
| | KDELR3 | ER lumen protein-retaining receptor. (214 aa) |
| | CCDC93 | Coiled-coil domain containing 93. (631 aa) |
| | PEF1 | Penta-EF-hand domain containing 1. (287 aa) |
| | SORCS1 | Sortilin related VPS10 domain containing receptor 1. (1051 aa) |
| | TMED4 | Transmembrane p24 trafficking protein 4. (216 aa) |
| | TRAPPC2 | Trafficking protein particle complex subunit 2; Prevents ENO1-mediated transcriptional repression and antagonizes ENO1-mediated cell death. May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity). (140 aa) |
| | TMED1 | Transmembrane emp24 domain-containing protein 1; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. (227 aa) |
| | ERGIC2 | ERGIC and golgi 2. (377 aa) |
| | USE1 | Uncharacterized protein. (297 aa) |
| | RAB8B | Ras-related protein Rab-8B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity). (207 aa) |
| | MYO1B | MYO1B protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1136 aa) |
| | RABEP1 | Rabaptin, RAB GTPase binding effector protein 1. (862 aa) |
| | PLPP3 | Phospholipid phosphatase 3; Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1- phosphate/C1P. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z- octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Has both an extracellular and an intracellular phosphatase activity, allowing the hydrolysis and the cellular uptake of the [...] (311 aa) |
| | CCDC91 | Coiled-coil domain containing 91. (442 aa) |
| | YIPF5 | Protein YIPF5; Plays a role in transport between endoplasmic reticulum and Golgi. (257 aa) |
| | RAB7B | Ras-related protein Rab-7b; Controls vesicular trafficking from endosomes to the trans- Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation [...] (200 aa) |
| | COG4 | Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. (785 aa) |
| | EXOC5 | Exocyst complex component 5. (708 aa) |
| | CEP19 | Centrosomal protein of 19 kDa; Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia. Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring at centrosomes. (163 aa) |
| | COPG1 | Coatomer subunit gamma-1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also i [...] (874 aa) |
| | TBC1D20 | TBC1 domain family member 20; GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude. (403 aa) |
| | RABIF | RAB interacting factor. (123 aa) |
| | SNX8 | Sorting nexin-8; May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network (By similarity). Belongs to the sorting nexin family. (459 aa) |
| | EXOC4 | Exocyst complex component 4. (975 aa) |
| | DOP1B | DOP1 leucine zipper like protein B. (1948 aa) |
| | SORL1 | Sortilin related receptor 1. (2211 aa) |
| | SEC22A | SEC22 homolog A, vesicle trafficking protein; Belongs to the synaptobrevin family. (307 aa) |
| | TRAPPC6B | Trafficking protein particle complex subunit 6B; Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic (By similarity). Specifically involved in the early development of neural circuitry, likely by controlling the frequency and amplitude of intracellular calcium transients implicated in the regulation of neuron differentiation and survival (By similarity). (158 aa) |
