STRINGSTRING
ISL2 ISL2 CTNNB1 CTNNB1 ASCL1 ASCL1 HOXD10 HOXD10 WNT1 WNT1 DLX1 DLX1 DMRT3 DMRT3 NOTCH1 NOTCH1 SIX1 SIX1 EYA1 EYA1 GBX1 GBX1 FOXN4 FOXN4 DMRTA2 DMRTA2 DLL4 DLL4 NKX2-2 NKX2-2 TLX3 TLX3 IHH IHH SMAD4 SMAD4 EHMT2 EHMT2 MNX1 MNX1 PRRX1 PRRX1 BMP4 BMP4 MYT1L MYT1L ATOH1 ATOH1 DBX1 DBX1 ISL1 ISL1 EPOP EPOP OLIG3 OLIG3 FOXA1 FOXA1 OLIG1 OLIG1 LHX3 LHX3 GSX1 GSX1 DLX2 DLX2 POU3F2 POU3F2 SHH SHH GLI3 GLI3 LBX1 LBX1 TBR1 TBR1 ID2 ID2 FEZF2 FEZF2 FEV FEV TGFBR1 TGFBR1 BCL11B BCL11B PTF1A PTF1A POU4F1 POU4F1 SOX9 SOX9 SUFU SUFU NKX2-1 NKX2-1 NKX6-2 NKX6-2 FOXG1 FOXG1 ZNF521 ZNF521 JAG2 JAG2 DLL1 DLL1 HOXC10 HOXC10 PAX6 PAX6 OLIG2 OLIG2 CDC42 CDC42 PROX1 PROX1 GSX2 GSX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ISL2ISL LIM homeobox 2. (359 aa)
CTNNB1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] (781 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (219 aa)
HOXD10HOXD10 protein. (340 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
DLX1Distal-less homeobox 1. (255 aa)
DMRT3Doublesex and mab-3 related transcription factor 3. (472 aa)
NOTCH1Notch receptor 1. (2533 aa)
SIX1SIX homeobox 1. (284 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa)
GBX1Gastrulation brain homeobox 1. (406 aa)
FOXN4Forkhead box N4. (518 aa)
DMRTA2Doublesex- and mab-3-related transcription factor A2; May be involved in sexual development; Belongs to the DMRT family. (535 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
NKX2-2NK2 homeobox 2. (273 aa)
TLX3Homeobox domain-containing protein. (291 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (412 aa)
SMAD4Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] (553 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1258 aa)
MNX1Motor neuron and pancreas homeobox 1. (409 aa)
PRRX1Paired related homeobox 1. (245 aa)
BMP4Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
MYT1LMyelin transcription factor 1-like. (1144 aa)
ATOH1Atonal bHLH transcription factor 1. (352 aa)
DBX1Homeobox protein DBX1; Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity); Belongs to the H2.0 homeobox family. (345 aa)
ISL1ISL LIM homeobox 1. (349 aa)
EPOPElongin BC and polycomb repressive complex 2 associated protein. (379 aa)
OLIG3Oligodendrocyte transcription factor 3. (272 aa)
FOXA1Forkhead box A1. (468 aa)
OLIG1Oligodendrocyte transcription factor 1. (266 aa)
LHX3LIM homeodomain 3 protein b isoform. (403 aa)
GSX1Uncharacterized protein. (163 aa)
DLX2Distal-less homeobox 2. (331 aa)
POU3F2POU domain protein. (438 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
GLI3GLI family zinc finger 3. (1587 aa)
LBX1Ladybird homeobox 1. (282 aa)
TBR1T-box brain transcription factor 1. (682 aa)
ID2DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the C [...] (134 aa)
FEZF2Fez family zinc finger protein 2; Transcription repressor. Binds to 5'GCAG-3' core sequence. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons (By similarity). May be responsible for mastitis resistance and innate immunity. (459 aa)
FEVFEV transcription factor, ETS family member. (239 aa)
TGFBR1TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] (499 aa)
BCL11BBAF chromatin remodeling complex subunit BCL11B. (904 aa)
PTF1APancreas associated transcription factor 1a. (326 aa)
POU4F1POU domain protein. (421 aa)
SOX9SRY-box transcription factor 9. (524 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
NKX2-1NK2 homeobox 1. (408 aa)
NKX6-2NK6 homeobox 2. (278 aa)
FOXG1Forkhead box G1. (490 aa)
ZNF521Zinc finger protein 521. (1351 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1069 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (784 aa)
HOXC10Homeobox C10. (373 aa)
PAX6Paired box protein Pax-6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity); Belongs to the paired homeobox family. (436 aa)
OLIG2Oligodendrocyte transcription factor 2. (327 aa)
CDC42Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (191 aa)
PROX1Prospero homeobox 1. (737 aa)
GSX2GS homeobox 2. (305 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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