STRINGSTRING
SIX1 SIX1 CHST11 CHST11 EIF4A3 EIF4A3 TGFBR1 TGFBR1 RDH10 RDH10 ALX3 ALX3 GLI3 GLI3 SLC39A1 SLC39A1 DLX2 DLX2 IFT140 IFT140 LHX1 LHX1 MTHFD1L MTHFD1L MMP16 MMP16 TGFBR2 TGFBR2 MED12 MED12 TWIST1 TWIST1 FGFR2 FGFR2 SLC39A3 SLC39A3 WNT9B WNT9B IRX5 IRX5 SIX4 SIX4 PDGFRA PDGFRA SETD2 SETD2 RUNX2 RUNX2 PAX5 PAX5 TFAP2A TFAP2A HOXA2 HOXA2 TBX15 TBX15 PRRX1 PRRX1 GRHL2 GRHL2 SIX2 SIX2 BMP4 BMP4 FGF8 FGF8 TULP3 TULP3 NIPBL NIPBL MMP14 MMP14 WDR19 WDR19 SMAD2 SMAD2 NODAL NODAL NDST1 NDST1 SMAD3 SMAD3 FOXC2 FOXC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SIX1SIX homeobox 1. (284 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
EIF4A3Eukaryotic initiation factor 4A-III, N-terminally processed; ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expr [...] (411 aa)
TGFBR1TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] (499 aa)
RDH10Retinol dehydrogenase 10; Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol (By similarity). (341 aa)
ALX3ALX homeobox 3. (343 aa)
GLI3GLI family zinc finger 3. (1587 aa)
SLC39A1Zinc transporter ZIP1; Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body (By similarity). Belongs to the ZIP transporter (TC 2.A.5) family. (324 aa)
DLX2Distal-less homeobox 2. (331 aa)
IFT140Intraflagellar transport 140. (1457 aa)
LHX1LIM homeobox 1. (406 aa)
MTHFD1LMonofunctional C1-tetrahydrofolate synthase, mitochondrial; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2; In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. (975 aa)
MMP16Matrix metallopeptidase 16. (607 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
MED12Mediator complex subunit 12. (2177 aa)
TWIST1Twist family bHLH transcription factor 1. (201 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
SLC39A3Zinc transporter ZIP3; Acts as a zinc-influx transporter; Belongs to the ZIP transporter (TC 2.A.5) family. (314 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
IRX5Iroquois homeobox 5. (500 aa)
SIX4SIX homeobox 4. (786 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1098 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2541 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (518 aa)
PAX5Paired box 5. (392 aa)
TFAP2ATranscription factor AP-2-alpha; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 [...] (452 aa)
HOXA2Homeobox protein Hox-A2; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. Proboscipedia subfamily. (372 aa)
TBX15T-box transcription factor 15. (607 aa)
PRRX1Paired related homeobox 1. (245 aa)
GRHL2Grainyhead like transcription factor 2. (625 aa)
SIX2SIX homeobox 2. (296 aa)
BMP4Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (478 aa)
NIPBLNipped-B protein. (2804 aa)
MMP14Matrix metalloproteinase-14; Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which in [...] (720 aa)
WDR19WD repeat domain 19. (1342 aa)
SMAD2Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] (467 aa)
NODALNodal growth differentiation factor. (346 aa)
NDST1N-deacetylase and N-sulfotransferase 1. (882 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
FOXC2Forkhead box C2. (502 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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