STRINGSTRING
HOXA9 HOXA9 TFAP2A TFAP2A PDGFRA PDGFRA HYAL1 HYAL1 FGF8 FGF8 HOXC4 HOXC4 BMP4 BMP4 SIX2 SIX2 GRHL2 GRHL2 PRRX1 PRRX1 HOXD3 HOXD3 HOXB7 HOXB7 HOXC9 HOXC9 HOXC11 HOXC11 HOXB1 HOXB1 TBX15 TBX15 HOXA2 HOXA2 HOXA3 HOXA3 HOXB2 HOXB2 GSC GSC CHST11 CHST11 EYA1 EYA1 PCGF2 PCGF2 SIX1 SIX1 HOXA5 HOXA5 FOXC2 FOXC2 SMAD3 SMAD3 NDST1 NDST1 NODAL NODAL COL2A1 COL2A1 OSR2 OSR2 SMAD2 SMAD2 WDR19 WDR19 HOXA11 HOXA11 MMP14 MMP14 ALX1 ALX1 NIPBL NIPBL TULP3 TULP3 FLVCR1 FLVCR1 EIF4A3 EIF4A3 HOXD10 HOXD10 HOXD9 HOXD9 CTNNB1 CTNNB1 TGFBR1 TGFBR1 RDH10 RDH10 ALX3 ALX3 HOXB3 HOXB3 HOXD4 HOXD4 DSCAML1 DSCAML1 GLI3 GLI3 SLC39A1 SLC39A1 MYF5 MYF5 ZEB1 ZEB1 HOXB4 HOXB4 SHOX2 SHOX2 DLX2 DLX2 ALX4 ALX4 IFT140 IFT140 LHX1 LHX1 MTHFD1L MTHFD1L BMP7 BMP7 MMP16 MMP16 HOXA4 HOXA4 HOXB5 HOXB5 TGFBR2 TGFBR2 OSR1 OSR1 MED12 MED12 TWIST1 TWIST1 NOG NOG HOXB9 HOXB9 BMI1 BMI1 FGFR2 FGFR2 WDR60 WDR60 SLC39A3 SLC39A3 WNT9B WNT9B HOXA7 HOXA7 IRX5 IRX5 SIX4 SIX4 DLG1 DLG1 SATB2 SATB2 SETD2 SETD2 MEGF8 MEGF8 HOXB6 HOXB6 HOXB8 HOXB8 RUNX2 RUNX2 PAX5 PAX5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HOXA9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (272 aa)
TFAP2ATranscription factor AP-2-alpha; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 [...] (452 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1098 aa)
HYAL1Hyaluronidase-1; May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth (By similarity). (450 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
HOXC4HOXC4 protein. (264 aa)
BMP4Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
SIX2SIX homeobox 2. (296 aa)
GRHL2Grainyhead like transcription factor 2. (625 aa)
PRRX1Paired related homeobox 1. (245 aa)
HOXD3Homeobox D3. (434 aa)
HOXB7Homeobox protein Hox-B7; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (217 aa)
HOXC9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (260 aa)
HOXC11Homeobox C11. (304 aa)
HOXB1Homeobox B1. (302 aa)
TBX15T-box transcription factor 15. (607 aa)
HOXA2Homeobox protein Hox-A2; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. Proboscipedia subfamily. (372 aa)
HOXA3Homeobox protein Hox-A3; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (442 aa)
HOXB2Homeobox B2. (354 aa)
GSCGoosecoid homeobox. (257 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
SIX1SIX homeobox 1. (284 aa)
HOXA5Homeobox protein Hox-A5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3' (By similarity); Belongs to the Antp homeobox family. (381 aa)
FOXC2Forkhead box C2. (502 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
NDST1N-deacetylase and N-sulfotransferase 1. (882 aa)
NODALNodal growth differentiation factor. (346 aa)
COL2A1Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. (1487 aa)
OSR2Protein odd-skipped-related 2. (276 aa)
SMAD2Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] (467 aa)
WDR19WD repeat domain 19. (1342 aa)
HOXA11Homeobox A11. (316 aa)
MMP14Matrix metalloproteinase-14; Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which in [...] (720 aa)
ALX1ALX homeobox 1. (295 aa)
NIPBLNipped-B protein. (2804 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (478 aa)
FLVCR1MFS domain-containing protein. (556 aa)
EIF4A3Eukaryotic initiation factor 4A-III, N-terminally processed; ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expr [...] (411 aa)
HOXD10HOXD10 protein. (340 aa)
HOXD9Homeobox D9. (345 aa)
CTNNB1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] (781 aa)
TGFBR1TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] (499 aa)
RDH10Retinol dehydrogenase 10; Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol (By similarity). (341 aa)
ALX3ALX homeobox 3. (343 aa)
HOXB3HOXB3 protein. (426 aa)
HOXD4HOXD4 protein. (258 aa)
DSCAML1DS cell adhesion molecule like 1. (1811 aa)
GLI3GLI family zinc finger 3. (1587 aa)
SLC39A1Zinc transporter ZIP1; Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body (By similarity). Belongs to the ZIP transporter (TC 2.A.5) family. (324 aa)
MYF5Myogenic factor 5; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (255 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1127 aa)
HOXB4Homeobox protein Hox-B4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. Deformed subfamily. (251 aa)
SHOX2Short stature homeobox 2. (353 aa)
DLX2Distal-less homeobox 2. (331 aa)
ALX4Homeobox protein aristaless-like 4; Transcription factor involved in skull and limb development. (397 aa)
IFT140Intraflagellar transport 140. (1457 aa)
LHX1LIM homeobox 1. (406 aa)
MTHFD1LMonofunctional C1-tetrahydrofolate synthase, mitochondrial; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2; In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. (975 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
MMP16Matrix metallopeptidase 16. (607 aa)
HOXA4Homeobox A4. (319 aa)
HOXB5Homeobox B5. (269 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
OSR1Protein odd-skipped-related 1; Transcription factor that plays a role in the regulation of embryonic heart and urogenital development; Belongs to the Odd C2H2-type zinc-finger protein family. (267 aa)
MED12Mediator complex subunit 12. (2177 aa)
TWIST1Twist family bHLH transcription factor 1. (201 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
HOXB9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (250 aa)
BMI1Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ub [...] (326 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
WDR60WD repeat domain 60. (1105 aa)
SLC39A3Zinc transporter ZIP3; Acts as a zinc-influx transporter; Belongs to the ZIP transporter (TC 2.A.5) family. (314 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
HOXA7Homeobox A7. (238 aa)
IRX5Iroquois homeobox 5. (500 aa)
SIX4SIX homeobox 4. (786 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (906 aa)
SATB2DNA-binding protein SATB. (733 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2541 aa)
MEGF8Multiple EGF like domains 8. (2810 aa)
HOXB6Homeobox B6. (224 aa)
HOXB8Homeobox B8. (243 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (518 aa)
PAX5Paired box 5. (392 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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