STRINGSTRING
UNC13B UNC13B STX1B STX1B SYT2 SYT2 RIMS1 RIMS1 RIMS2 RIMS2 SYT8 SYT8 STXBP1 STXBP1 UNC13A UNC13A DOC2B DOC2B RIMS3 RIMS3 SYT1 SYT1 SYT5 SYT5 UNC13C UNC13C
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UNC13BUnc-13 homolog B. (1610 aa)
STX1BSyntaxin-1B; Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity). (414 aa)
SYT2Synaptotagmin 2. (519 aa)
RIMS1Regulating synaptic membrane exocytosis 1. (1623 aa)
RIMS2Regulating synaptic membrane exocytosis 2. (1137 aa)
SYT8Synaptotagmin 8. (425 aa)
STXBP1Syntaxin-binding protein 1; Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions (By similarity). (603 aa)
UNC13AUnc-13 homolog A. (1701 aa)
DOC2BDouble C2-like domain-containing protein. (412 aa)
RIMS3Regulating synaptic membrane exocytosis 3. (308 aa)
SYT1Synaptotagmin-1; Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)- dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-in [...] (442 aa)
SYT5Synaptotagmin 5. (386 aa)
UNC13CUnc-13 homolog C. (2070 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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