STRINGSTRING
TSHZ1 TSHZ1 INHBA INHBA INSIG2 INSIG2 FZD2 FZD2 BCOR BCOR OSR1 OSR1 TGFBR2 TGFBR2 FRAS1 FRAS1 HAND2 HAND2 BNC2 BNC2 FOXE1 FOXE1 WNT3A WNT3A TBC1D32 TBC1D32 ALX4 ALX4 MSC MSC FOXF2 FOXF2 SHH SHH DHRS3 DHRS3 GLI3 GLI3 VAX1 VAX1 TCF21 TCF21 DLX6 DLX6 ANP32B ANP32B WNT5A WNT5A EPHB2 EPHB2 CHD7 CHD7 PKDCC PKDCC PAK1IP1 PAK1IP1 DLX5 DLX5 LOXL3 LOXL3 TGFBR1 TGFBR1 NPRL3 NPRL3 MMP25 MMP25 TBX2 TBX2 SMAD2 SMAD2 OSR2 OSR2 COL2A1 COL2A1 INTU INTU TIPARP TIPARP SOS1 SOS1 MSX1 MSX1 WNT11 WNT11 ITGB6 ITGB6 GDF11 GDF11 SMAD4 SMAD4 EPHB3 EPHB3 WDPCP WDPCP PRRX1 PRRX1 ITGB8 ITGB8 MEOX2 MEOX2 IRF6 IRF6 WFIKKN1 WFIKKN1 TMEM107 TMEM107 WNT7A WNT7A LRRC32 LRRC32 WFIKKN2 WFIKKN2 CPLANE1 CPLANE1 BMPR1A BMPR1A TFAP2A TFAP2A PDGFRA PDGFRA SATB2 SATB2 DLG1 DLG1 JAG2 JAG2 CSRNP1 CSRNP1 SUMO1 SUMO1 PLEKHA1 PLEKHA1 INSIG1 INSIG1 TBX3 TBX3 ARID5B ARID5B WNT9B WNT9B LEF1 LEF1 SNAI1 SNAI1 SCHIP1 SCHIP1 SGPL1 SGPL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TSHZ1Teashirt zinc finger homeobox 1. (1121 aa)
INHBAInhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (425 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (245 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
BCORBCL6 corepressor. (1766 aa)
OSR1Protein odd-skipped-related 1; Transcription factor that plays a role in the regulation of embryonic heart and urogenital development; Belongs to the Odd C2H2-type zinc-finger protein family. (267 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
FRAS1Fraser extracellular matrix complex subunit 1. (3979 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
BNC2Basonuclin 2. (1085 aa)
FOXE1Forkhead box E1. (373 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (346 aa)
TBC1D32TBC1 domain family member 32. (1296 aa)
ALX4Homeobox protein aristaless-like 4; Transcription factor involved in skull and limb development. (397 aa)
MSCMusculin. (197 aa)
FOXF2Forkhead box F2. (444 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
DHRS3Short-chain dehydrogenase/reductase 3; Catalyzes the reduction of all-trans-retinal to all-trans- retinol in the presence of NADPH; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
GLI3GLI family zinc finger 3. (1587 aa)
VAX1Ventral anterior homeobox 1. (334 aa)
TCF21Transcription factor 21; Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types (By similarity). (179 aa)
DLX6Distal-less homeobox 6. (175 aa)
ANP32BAcidic leucine-rich nuclear phosphoprotein 32 family member B; Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity. Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome (By similarity). (271 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
EPHB2EPH receptor B2. (965 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2786 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (493 aa)
PAK1IP1P21-activated protein kinase-interacting protein 1; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly. (393 aa)
DLX5Distal-less homeobox 5. (289 aa)
LOXL3Lysyl oxidase like 3. (752 aa)
TGFBR1TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] (499 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (569 aa)
MMP25Matrix metallopeptidase 25. (557 aa)
TBX2T-box transcription factor 2. (714 aa)
SMAD2Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] (467 aa)
OSR2Protein odd-skipped-related 2. (276 aa)
COL2A1Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. (1487 aa)
INTUProtein inturned; Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity ef [...] (933 aa)
TIPARPTCDD inducible poly(ADP-ribose) polymerase. (656 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ITGB6Integrin beta-6; Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R- G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). (808 aa)
GDF11Growth differentiation factor 11. (406 aa)
SMAD4Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] (553 aa)
EPHB3EPH receptor B3. (997 aa)
WDPCPWD repeat containing planar cell polarity effector. (645 aa)
PRRX1Paired related homeobox 1. (245 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (767 aa)
MEOX2Mesenchyme homeobox 2. (303 aa)
IRF6Interferon regulatory factor 6; Probable DNA-binding transcriptional activator. It is a key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity); Belongs to the IRF family. (466 aa)
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (550 aa)
TMEM107Transmembrane protein 107. (140 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
LRRC32Leucine rich repeat containing 32. (662 aa)
WFIKKN2WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2; Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease- inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin (By similarity). (574 aa)
CPLANE1Ciliogenesis and planar polarity effector 1. (3117 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TFAP2ATranscription factor AP-2-alpha; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 [...] (452 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1098 aa)
SATB2DNA-binding protein SATB. (733 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (906 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1069 aa)
CSRNP1Cysteine and serine rich nuclear protein 1. (605 aa)
SUMO1Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] (216 aa)
PLEKHA1Pleckstrin homology domain containing A1. (404 aa)
INSIG1Insulin-induced gene 1 protein; Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin- mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May pla [...] (276 aa)
TBX3T-box transcription factor 3. (748 aa)
ARID5BAT-rich interactive domain-containing protein 5B; Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-340, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride m [...] (1181 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
SNAI1Snail family transcriptional repressor 1. (267 aa)
SCHIP1SCHIP-1 domain-containing protein. (481 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (577 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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