STRINGSTRING
NRP2 NRP2 JAG1 JAG1 SMAD4 SMAD4 SEMA3C SEMA3C GATA6 GATA6 GATA4 GATA4 LRP2 LRP2 BMP4 BMP4 HAND1 HAND1 ZFPM2 ZFPM2 SAV1 SAV1 FGF8 FGF8 ISL1 ISL1 TP53 TP53 HEY2 HEY2 SMAD6 SMAD6 HES1 HES1 BMPR1A BMPR1A HEYL HEYL WNT11 WNT11 CITED2 CITED2 TBX5 TBX5 SMO SMO NOTCH1 NOTCH1 TBX2 TBX2 TBX20 TBX20 TGFBR1 TGFBR1 CHD7 CHD7 WNT5A WNT5A NKX2-5 NKX2-5 DHRS3 DHRS3 APLNR APLNR SMAD7 SMAD7 ZFPM1 ZFPM1 MKS1 MKS1 SLIT3 SLIT3 ENG ENG RBM15 RBM15 BMP7 BMP7 DNAH11 DNAH11 TGFBR2 TGFBR2 FZD2 FZD2 NOG NOG PROX1 PROX1 BMPR2 BMPR2 CCN1 CCN1 PARVA PARVA TBX3 TBX3 EGLN1 EGLN1 NOTCH2 NOTCH2 NSD2 NSD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NRP2Neuropilin; Belongs to the neuropilin family. (926 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
SMAD4Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] (553 aa)
SEMA3CSemaphorin-3C; Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity). (751 aa)
GATA6GATA binding protein 6. (593 aa)
GATA4GATA binding protein 4. (442 aa)
LRP2LDL receptor related protein 2. (4622 aa)
BMP4Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
HAND1Heart- and neural crest derivatives-expressed protein 1; Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes (By similarity). (218 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1149 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
ISL1ISL LIM homeobox 1. (349 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (386 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
SMAD6Mothers against decapentaplegic homolog. (529 aa)
HES1Transcription factor HES-1; Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'- CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity). (280 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
HEYLHairy/enhancer-of-split related with YRPW motif-like protein; Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6; Belongs to the HEY family. (328 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
CITED2Cbp/p300-interacting transactivator 2; Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts [...] (273 aa)
TBX5T-box transcription factor 5. (561 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
NOTCH1Notch receptor 1. (2533 aa)
TBX2T-box transcription factor 2. (714 aa)
TBX20T-box transcription factor 20. (449 aa)
TGFBR1TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] (499 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2786 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
NKX2-5NK2 transcription factor related, locus 5 (Drosophila). (323 aa)
DHRS3Short-chain dehydrogenase/reductase 3; Catalyzes the reduction of all-trans-retinal to all-trans- retinol in the presence of NADPH; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (400 aa)
SMAD7Mothers against decapentaplegic homolog. (430 aa)
ZFPM1Zinc finger protein, FOG family member 1. (986 aa)
MKS1MKS transition zone complex subunit 1. (558 aa)
SLIT3Slit guidance ligand 3. (1475 aa)
ENGZP domain-containing protein. (650 aa)
RBM15RNA binding motif protein 15. (962 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
DNAH11Dynein axonemal heavy chain 11. (4501 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
PROX1Prospero homeobox 1. (737 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
CCN1Cellular communication network factor 1. (463 aa)
PARVAParvin alpha. (455 aa)
TBX3T-box transcription factor 3. (748 aa)
EGLN1Uncharacterized protein. (420 aa)
NOTCH2Notch receptor 2. (2471 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1365 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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