node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDKN1B | CTNNB1 | ENSBTAP00000024297 | ENSBTAP00000021838 | Cyclin dependent kinase inhibitor 1B. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | 0.547 |
CDKN1B | SHH | ENSBTAP00000024297 | ENSBTAP00000034059 | Cyclin dependent kinase inhibitor 1B. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.461 |
CTNNB1 | CDKN1B | ENSBTAP00000021838 | ENSBTAP00000024297 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | Cyclin dependent kinase inhibitor 1B. | 0.547 |
CTNNB1 | SHH | ENSBTAP00000021838 | ENSBTAP00000034059 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.765 |
CTNNB1 | SOX9 | ENSBTAP00000021838 | ENSBTAP00000073259 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | SRY-box transcription factor 9. | 0.979 |
CTNNB1 | STK11 | ENSBTAP00000021838 | ENSBTAP00000015459 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. | 0.477 |
SHH | CDKN1B | ENSBTAP00000034059 | ENSBTAP00000024297 | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | Cyclin dependent kinase inhibitor 1B. | 0.461 |
SHH | CTNNB1 | ENSBTAP00000034059 | ENSBTAP00000021838 | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | 0.765 |
SHH | SOX9 | ENSBTAP00000034059 | ENSBTAP00000073259 | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | SRY-box transcription factor 9. | 0.738 |
SOX9 | CTNNB1 | ENSBTAP00000073259 | ENSBTAP00000021838 | SRY-box transcription factor 9. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | 0.979 |
SOX9 | SHH | ENSBTAP00000073259 | ENSBTAP00000034059 | SRY-box transcription factor 9. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.738 |
STK11 | CTNNB1 | ENSBTAP00000015459 | ENSBTAP00000021838 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | 0.477 |