node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABHD4 | NAAA | ENSBTAP00000022154 | ENSBTAP00000025945 | (Lyso)-N-acylphosphatidylethanolamine lipase; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N- acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatid [...] | N-acylethanolamine acid amidase; Belongs to the acid ceramidase family. | 0.401 |
ABHD4 | NAPEPLD | ENSBTAP00000022154 | ENSBTAP00000067871 | (Lyso)-N-acylphosphatidylethanolamine lipase; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N- acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatid [...] | N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D; Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid. Responsible for the generation of these bioactive fatty acid ethanolamides (FAEs), including anandamide (N-arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors (By similarity). As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis [...] | 0.831 |
ABHD4 | PLAAT5 | ENSBTAP00000022154 | ENSBTAP00000043778 | (Lyso)-N-acylphosphatidylethanolamine lipase; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N- acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatid [...] | HRASLS5 protein. | 0.407 |
ENSBTAP00000070888 | ENSBTAP00000071798 | ENSBTAP00000070888 | ENSBTAP00000071798 | LRAT domain-containing protein. | LRAT domain-containing protein. | 0.902 |
ENSBTAP00000070888 | PLA2G16 | ENSBTAP00000070888 | ENSBTAP00000073750 | LRAT domain-containing protein. | LRAT domain-containing protein. | 0.902 |
ENSBTAP00000070888 | PLA2G4E | ENSBTAP00000070888 | ENSBTAP00000065921 | LRAT domain-containing protein. | Phospholipase A2. | 0.667 |
ENSBTAP00000071798 | ENSBTAP00000070888 | ENSBTAP00000071798 | ENSBTAP00000070888 | LRAT domain-containing protein. | LRAT domain-containing protein. | 0.902 |
ENSBTAP00000071798 | PLA2G16 | ENSBTAP00000071798 | ENSBTAP00000073750 | LRAT domain-containing protein. | LRAT domain-containing protein. | 0.903 |
ENSBTAP00000071798 | PLA2G4E | ENSBTAP00000071798 | ENSBTAP00000065921 | LRAT domain-containing protein. | Phospholipase A2. | 0.657 |
NAAA | ABHD4 | ENSBTAP00000025945 | ENSBTAP00000022154 | N-acylethanolamine acid amidase; Belongs to the acid ceramidase family. | (Lyso)-N-acylphosphatidylethanolamine lipase; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N- acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatid [...] | 0.401 |
NAAA | NAPEPLD | ENSBTAP00000025945 | ENSBTAP00000067871 | N-acylethanolamine acid amidase; Belongs to the acid ceramidase family. | N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D; Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid. Responsible for the generation of these bioactive fatty acid ethanolamides (FAEs), including anandamide (N-arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors (By similarity). As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis [...] | 0.848 |
NAAA | PLAAT5 | ENSBTAP00000025945 | ENSBTAP00000043778 | N-acylethanolamine acid amidase; Belongs to the acid ceramidase family. | HRASLS5 protein. | 0.440 |
NAPEPLD | ABHD4 | ENSBTAP00000067871 | ENSBTAP00000022154 | N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D; Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid. Responsible for the generation of these bioactive fatty acid ethanolamides (FAEs), including anandamide (N-arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors (By similarity). As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis [...] | (Lyso)-N-acylphosphatidylethanolamine lipase; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N- acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatid [...] | 0.831 |
NAPEPLD | NAAA | ENSBTAP00000067871 | ENSBTAP00000025945 | N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D; Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid. Responsible for the generation of these bioactive fatty acid ethanolamides (FAEs), including anandamide (N-arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors (By similarity). As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis [...] | N-acylethanolamine acid amidase; Belongs to the acid ceramidase family. | 0.848 |
NAPEPLD | PLA2G4E | ENSBTAP00000067871 | ENSBTAP00000065921 | N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D; Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid. Responsible for the generation of these bioactive fatty acid ethanolamides (FAEs), including anandamide (N-arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors (By similarity). As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis [...] | Phospholipase A2. | 0.443 |
NAPEPLD | PLAAT5 | ENSBTAP00000067871 | ENSBTAP00000043778 | N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D; Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid. Responsible for the generation of these bioactive fatty acid ethanolamides (FAEs), including anandamide (N-arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors (By similarity). As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis [...] | HRASLS5 protein. | 0.459 |
PLA2G16 | ENSBTAP00000070888 | ENSBTAP00000073750 | ENSBTAP00000070888 | LRAT domain-containing protein. | LRAT domain-containing protein. | 0.902 |
PLA2G16 | ENSBTAP00000071798 | ENSBTAP00000073750 | ENSBTAP00000071798 | LRAT domain-containing protein. | LRAT domain-containing protein. | 0.903 |
PLA2G16 | PLA2G4E | ENSBTAP00000073750 | ENSBTAP00000065921 | LRAT domain-containing protein. | Phospholipase A2. | 0.667 |
PLA2G4E | ENSBTAP00000070888 | ENSBTAP00000065921 | ENSBTAP00000070888 | Phospholipase A2. | LRAT domain-containing protein. | 0.667 |