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| | GDF1 | Growth differentiation factor 1. (369 aa) |
| | BMPR1A | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa) |
| | TOB1 | Transducer of ERBB2, 1. (341 aa) |
| | HES1 | Transcription factor HES-1; Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'- CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity). (280 aa) |
| | SMAD6 | Mothers against decapentaplegic homolog. (529 aa) |
| | ILK | Integrin-linked protein kinase; Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. (452 aa) |
| | WFIKKN2 | WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2; Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease- inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin (By similarity). (574 aa) |
| | GIPC1 | GIPC PDZ domain containing family member 1. (333 aa) |
| | KDR | Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa) |
| | FOLR1 | Folate receptor alpha. (258 aa) |
| | BMP10 | Bone morphogenetic protein 10. (424 aa) |
| | GDF10 | Growth/differentiation factor 10; Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis. (478 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (386 aa) |
| | RNF165 | Ring finger protein 165. (347 aa) |
| | ADAM17 | ADAM metallopeptidase domain 17. (825 aa) |
| | TWSG1 | Twisted gastrulation BMP signaling modulator 1. (223 aa) |
| | TGFB1I1 | Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. [...] (456 aa) |
| | HES5 | Hes family bHLH transcription factor 5. (227 aa) |
| | FBXL15 | F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity); Belongs to the FBXL15 family. (335 aa) |
| | WFIKKN1 | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (550 aa) |
| | LRG1 | Leucine rich alpha-2-glycoprotein 1. (353 aa) |
| | LOC100336971 | Left-right determination factor. (367 aa) |
| | BAMBI | BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa) |
| | PELO | Protein pelota homolog; Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential). Belongs to the eukaryotic release factor 1 family. Pelota subfamily. (386 aa) |
| | FST | Follistatin; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). (344 aa) |
| | FAM89B | Family with sequence similarity 89 member B. (192 aa) |
| | BMP4 | Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa) |
| | CREBBP | CREB binding protein. (2435 aa) |
| | KIAA1324L | UPF0577 protein KIAA1324-like homolog. (959 aa) |
| | SKIL | SKI like proto-oncogene. (684 aa) |
| | GDF5 | Growth differentiation factor 5. (499 aa) |
| | CHRDL1 | Chordin like 1. (530 aa) |
| | LRP2 | LDL receptor related protein 2. (4622 aa) |
| | NEO1 | Neogenin 1. (1464 aa) |
| | GDF2 | Growth differentiation factor 2. (431 aa) |
| | BMP2 | Bone morphogenetic protein 2. (395 aa) |
| | SOSTDC1 | Sclerostin domain containing 1. (206 aa) |
| | INHBE | Inhibin subunit beta E. (348 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] (553 aa) |
| | GDF11 | Growth differentiation factor 11. (406 aa) |
| | FLCN | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. (579 aa) |
| | SPART | Spartin; May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis. (668 aa) |
| | PPARA | Peroxisome proliferative activated receptor, alpha isoform 1. (470 aa) |
| | SNW1 | SNW domain-containing protein 1; Involved in pre-mRNA splicing as component of the spliceosome. Is required in the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, [...] (536 aa) |
| | HTRA1 | Serine protease HTRA1; Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF- binding proteins. Inhibits sign [...] (528 aa) |
| | GDF9 | Growth/differentiation factor 9; Required for ovarian folliculogenesis. (453 aa) |
| | NRROS | Transforming growth factor beta activator LRRC33; Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1. TGF- beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighbo [...] (692 aa) |
| | INHA | Inhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins; Belongs to the TGF-beta family. (360 aa) |
| | MYOCD | Myocardin. (982 aa) |
| | CHST11 | Carbohydrate sulfotransferase. (352 aa) |
| | MSX1 | Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa) |
| | CITED2 | Cbp/p300-interacting transactivator 2; Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts [...] (273 aa) |
| | EMILIN1 | Elastin microfibril interfacer 1. (1015 aa) |
| | NREP | LOC100125763 protein. (68 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (435 aa) |
| | MSTN | Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth. (375 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (425 aa) |
| | BMP5 | Bone morphogenetic protein 5. (454 aa) |
| | HFE | Homeostatic iron regulator; Belongs to the MHC class I family. (356 aa) |
| | NODAL | Nodal growth differentiation factor. (346 aa) |
| | SMAD2 | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] (467 aa) |
| | NOTCH1 | Notch receptor 1. (2533 aa) |
| | ACVRL1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa) |
| | ZNF703 | Zinc finger protein 703. (587 aa) |
| | SIRT1 | Sirtuin 1. (734 aa) |
| | STRAP | Serine-threonine kinase receptor-associated protein; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICl [...] (350 aa) |
| | RNF111 | Ring finger protein 111. (994 aa) |
| | PBLD | Phenazine biosynthesis-like domain-containing protein. (288 aa) |
| | LATS2 | Large tumor suppressor kinase 2. (1015 aa) |
| | SORL1 | Sortilin related receptor 1. (2211 aa) |
| | LATS1 | Large tumor suppressor kinase 1. (1123 aa) |
| | DLX1 | Distal-less homeobox 1. (255 aa) |
| | FBN2 | Fibrillin 2. (2912 aa) |
| | WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) |
| | LEMD2 | LEM domain containing 2. (495 aa) |
| | GDF15 | Growth differentiation factor 15. (308 aa) |
| | DAB2 | DAB adaptor protein 2. (768 aa) |
| | EP300 | E1A binding protein p300. (2411 aa) |
| | IL17F | Interleukin 17F. (170 aa) |
| | PIN1 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs. By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes. Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis- promoting activity. Down-regulates kinase activity of BTK. Can transactivate multiple [...] (163 aa) |
| | ZNF423 | Zinc finger protein 423. (1292 aa) |
| | TBX20 | T-box transcription factor 20. (449 aa) |
| | BMP3 | Bone morphogenetic protein 3; Induces cartilage and bone formation. (475 aa) |
| | DMRT1 | Doublesex and mab-3 related transcription factor 1; Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promo [...] (357 aa) |
| | CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa) |
| | BMP8A | TGF_BETA_2 domain-containing protein. (405 aa) |
| | TGFBR1 | TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] (499 aa) |
| | ACVR2A | Activin receptor type-2A; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa) |
| | NUMA1 | Nuclear mitotic apparatus protein 1. (2095 aa) |
| | SFRP5 | Secreted frizzled-related protein 5; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps other, cells in the retina. Inhibits Wnt8 signaling, in vitro. (315 aa) |
| | PRDM16 | PR/SET domain 16. (1154 aa) |
| | INHBC | Inhibin subunit beta C. (352 aa) |
| | SH2B1 | SH2B adaptor protein 1. (756 aa) |
| | BMP6 | Bone morphogenetic protein 6. (496 aa) |
| | ITGA3 | Integrin alpha-3 heavy chain; Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha- 3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. (1065 aa) |
| | LTBP1 | Latent transforming growth factor beta binding protein 1. (1708 aa) |
| | SDCBP | Syndecan binding protein. (360 aa) |
| | UBE2O | Ubiquitin conjugating enzyme E2 O. (1287 aa) |
| | CER1 | Cerberus 1, DAN family BMP antagonist. (273 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | GPC3 | Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa) |
| | RASL11B | Ras-like protein family member 11B; Belongs to the small GTPase superfamily. Ras family. (248 aa) |
| | NANOG | Homeobox protein NANOG; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator and repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT [...] (300 aa) |
| | SPRY1 | Protein sprouty homolog 1; May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. (319 aa) |
| | ZC3H3 | Zinc finger CCCH-type containing 3. (878 aa) |
| | HJV | Hemojuvelin BMP co-receptor. (427 aa) |
| | KIAA0319 | KIAA0319. (1066 aa) |
| | SFRP2 | Secreted frizzled-related protein 2. (294 aa) |
| | CAV3 | Caveolin-3; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae. Belongs to the caveolin family. (151 aa) |
| | GDF3 | TGF_BETA_2 domain-containing protein. (364 aa) |
| | VEPH1 | Ventricular zone expressed PH domain containing 1. (798 aa) |
| | ASPN | Asporin. (370 aa) |
| | ZEB1 | Zinc finger E-box binding homeobox 1. (1127 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1. (557 aa) |
| | SFRP1 | Secreted frizzled-related protein 1; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metane [...] (308 aa) |
| | CRB2 | Crumbs cell polarity complex component 2. (1281 aa) |
| | SMURF1 | E3 ubiquitin-protein ligase. (731 aa) |
| | DACT2 | Dishevelled binding antagonist of beta catenin 2. (729 aa) |
| | CSNK2B | Casein kinase II subunit beta; Participates in Wnt signaling. Plays a complex role in regulating the basal catalytic activity of the alpha subunit (By similarity); Belongs to the casein kinase 2 subunit beta family. (215 aa) |
| | TMPRSS6 | Transmembrane serine protease 6; Belongs to the peptidase S1 family. (839 aa) |
| | CHRD | Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (958 aa) |
| | GDF6 | Growth/differentiation factor 6; Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal- ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-speci [...] (470 aa) |
| | HOXA13 | Homeobox A13. (388 aa) |
| | SPRED1 | Sprouty related EVH1 domain containing 1. (443 aa) |
| | SPRY2 | Protein sprouty homolog 2; May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. (315 aa) |
| | ACVR1B | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa) |
| | SMAD7 | Mothers against decapentaplegic homolog. (430 aa) |
| | SKOR2 | SKI family transcriptional corepressor 2. (1003 aa) |
| | LEMD3 | LEM domain containing 3. (912 aa) |
| | EID2 | EP300-interacting inhibitor of differentiation 2; Interacts with EP300 and acts as a repressor of MYOD- dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3- dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex (By similarity). (219 aa) |
| | NEPN | NEPN protein. (512 aa) |
| | ENG | ZP domain-containing protein. (650 aa) |
| | LEFTY2 | Left-right determination factor. (367 aa) |
| | F1MKJ7_BOVIN | TGF_BETA_2 domain-containing protein. (364 aa) |
| | SULF1 | Sulfatase 1. (1109 aa) |
| | GDF7 | Growth differentiation factor 7. (450 aa) |
| | HSPA5 | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (655 aa) |
| | BMP7 | Bone morphogenetic protein 7. (431 aa) |
| | IL17RD | Interleukin 17 receptor D. (736 aa) |
| | VWC2 | Von Willebrand factor C domain containing 2. (326 aa) |
| | SKI | SKI proto-oncogene. (729 aa) |
| | BMP8B | TGF_BETA_2 domain-containing protein. (405 aa) |
| | ING2 | Inhibitor of growth protein. (283 aa) |
| | HTRA3 | HtrA serine peptidase 3. (416 aa) |
| | KCP | Kielin cysteine rich BMP regulator. (1596 aa) |
| | CDH5 | Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (By similarity). Acts in concert with KRIT1 and MPP5 to establish and maintain correct endotheli [...] (783 aa) |
| | TGFBR2 | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa) |
| | VASN | VASN protein. (673 aa) |
| | FGF9 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | IGSF1-2 | Immunoglobulin superfamily member 1. (750 aa) |
| | ONECUT1 | One cut domain family member. (465 aa) |
| | BMP15 | Bone morphogenetic protein 15; May be involved in follicular development. Seems to be an oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity). (394 aa) |
| | NOG | Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa) |
| | VWC2L | VWFC domain-containing protein. (222 aa) |
| | INHBA | Inhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (425 aa) |
| | GLG1 | Golgi glycoprotein 1. (1185 aa) |
| | UCMA | Uncharacterized protein. (136 aa) |
| | ZBTB7A | Zinc finger and BTB domain containing 7A. (595 aa) |
| | PPM1A | Protein phosphatase 1A; Enzyme with a broad specificity. Negatively regulates TGF- beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling (By similarity). Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB (By similarity). (454 aa) |
| | CAV2 | Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity). (162 aa) |
| | INHBB | Inhibin beta B chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (408 aa) |
| | CD109 | CD109 molecule. (1455 aa) |
| | ABL1 | Tyrosine-protein kinase. (1151 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa) |
| | SMURF2 | E3 ubiquitin-protein ligase. (738 aa) |
| | ENSBTAP00000059777 | Uncharacterized protein. (65 aa) |
| | CCN1 | Cellular communication network factor 1. (463 aa) |
| | FKBP1A-2 | Peptidyl-prolyl cis-trans isomerase FKBP1A; Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (108 aa) |
| | TRIM33 | Tripartite motif containing 33. (1126 aa) |
| | SOX11 | Transcription factor SOX. (451 aa) |
| | TGFBR3 | Transforming growth factor beta receptor 3. (858 aa) |
| | CTDSPL2 | CTD small phosphatase like 2. (466 aa) |
| | CIDEA | CIDEA protein. (219 aa) |
| | GREM1 | CTCK domain-containing protein. (240 aa) |
| | MPP5 | Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa) |
| | TGFB2 | Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (442 aa) |
| | FBN1 | Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...] (2990 aa) |
| | TFAP2B | Transcription factor AP-2 beta. (488 aa) |
| | TGFB1 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (499 aa) |
| | ONECUT2 | One cut domain family member. (557 aa) |
| | BMPER | BMP binding endothelial regulator. (687 aa) |
| | CDKN2B | Cyclin-dependent kinase 4 inhibitor B; Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest (By similarity); Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. (321 aa) |
| | BCL9L | BCL9 like. (1495 aa) |
| | MEN1 | Menin; Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the [...] (610 aa) |
| | SOST | Sclerostin; Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. (292 aa) |
| | TNFAIP6 | Tumor necrosis factor, alpha-induced protein 6. (280 aa) |
| | FERMT1 | Fermitin family member 1. (679 aa) |
| | ENSBTAP00000067700 | Uncharacterized protein. (228 aa) |
| | CHRDL2 | Chordin like 2. (467 aa) |
| | CDKN1C | Cyclin dependent kinase inhibitor 1C. (301 aa) |
| | AXIN1 | Axin 1. (866 aa) |
| | NUP93 | Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling. (819 aa) |
| | ADAMTSL2 | ADAMTS like 2. (1013 aa) |
| | CRIM1 | Cysteine rich transmembrane BMP regulator 1. (1035 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa) |
| | LDLRAD4 | Low density lipoprotein receptor class A domain containing 4. (332 aa) |
| | NKX2-1 | NK2 homeobox 1. (408 aa) |
| | LOX | Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family. (418 aa) |
| | C13H20orf27 | UPF0687 protein C20orf27 homolog; Belongs to the UPF0687 family. (205 aa) |
| | FKBP1A | Peptidylprolyl isomerase. (128 aa) |
| | LOC535280 | CTCK domain-containing protein. (519 aa) |
| | ZNF451 | Zinc finger protein 451. (1074 aa) |
| | PMEPA1 | Uncharacterized protein. (339 aa) |
| | FSTL3 | Follistatin-related protein 3; The secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiation. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. The nucl [...] (262 aa) |
| | HSP90AB1 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] (724 aa) |
| | SLC2A10 | Solute carrier family 2 member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (570 aa) |
| | NPNT | Nephronectin. (616 aa) |
| | SCUBE3 | Signal peptide, CUB domain and EGF like domain containing 3. (1009 aa) |
| | HIPK2 | Homeodomain interacting protein kinase 2. (1206 aa) |
| | NOTCH2 | Notch receptor 2. (2471 aa) |
| | FSTL1 | Follistatin-related protein 1; May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity). (312 aa) |
| | THBS1 | Thrombospondin-1; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions. Ligand for CD36 mediating antiangiogenic properties (By similarity). May play a role in dentinogenesis and/or maintenance of dentin and dental pulp. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity); Belongs to the thrombospondin family. (1175 aa) |
| | SNX25 | Sorting nexin 25. (944 aa) |
