STRINGSTRING
CYREN CYREN SIRT7 SIRT7 PNKP PNKP SMCHD1 SMCHD1 NUDT16L1 NUDT16L1 NSD2 NSD2 DTX3L DTX3L DEK DEK POT1 POT1 MRNIP MRNIP PRKDC PRKDC SHLD2 SHLD2 RIF1 RIF1 AUNIP AUNIP PARP9 PARP9 PARP3 PARP3 ERCC6 ERCC6 SHLD3 SHLD3 HMGA2 HMGA2 WRAP53 WRAP53 MAD2L2 MAD2L2 HSF1 HSF1 SHLD1 SHLD1 KMT5C KMT5C KMT5B KMT5B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CYRENCell cycle regulator of NHEJ. (173 aa)
SIRT7NAD-dependent protein deacetylase sirtuin-7; NAD-dependent protein-lysine deacylase that can act both as a deacetylase or deacylase (desuccinylase, depropionylase and deglutarylase), depending on the context. Specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays strong preference for a specific histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors; SIRT7 thereby acts a [...] (400 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (522 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain containing 1. (1997 aa)
NUDT16L1Nudix (Nucleoside diphosphate linked moiety X)-type motif 16-like 1. (211 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1365 aa)
DTX3LDeltex E3 ubiquitin ligase 3L. (739 aa)
DEKDEK proto-oncogene. (375 aa)
POT1Protection of telomeres 1. (638 aa)
MRNIPMRN complex-interacting protein; Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex. Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair; Belongs to the MRNIP family. (369 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4124 aa)
SHLD2Shieldin complex subunit 2. (906 aa)
RIF1Replication timing regulatory factor 1. (2313 aa)
AUNIPAurora kinase A and ninein-interacting protein; DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination. Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair. Inhibits non-homologous end joining (NHEJ). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during [...] (357 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (969 aa)
PARP3Poly [ADP-ribose] polymerase. (512 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1481 aa)
SHLD3Shieldin complex subunit 3. (252 aa)
HMGA2High mobility group AT-hook 2. (109 aa)
WRAP53Telomerase Cajal body protein 1; RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies. Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex. Acts by specifically b [...] (595 aa)
MAD2L2Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks [...] (263 aa)
HSF1Heat shock factor protein 1; Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones heat shock proteins (HSPs) that protect cells from cellular insults' damage. In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non- DNA-binding inactivated monomeric form. Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcriptio [...] (553 aa)
SHLD1Shieldin complex subunit 1; Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres. (206 aa)
KMT5CLysine methyltransferase 5C. (470 aa)
KMT5BHistone-lysine N-methyltransferase KMT5B; Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromat [...] (911 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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