STRINGSTRING
ENSBTAP00000070818 ENSBTAP00000070818 ENSBTAP00000070247 ENSBTAP00000070247 FBXL5 FBXL5 CKS1B CKS1B CCNF CCNF SKP1 SKP1 LOC525426 LOC525426 G3N0Q3_BOVIN G3N0Q3_BOVIN ENSBTAP00000056926 ENSBTAP00000056926 ENSBTAP00000057099 ENSBTAP00000057099 FBXL14 FBXL14 FBXO2 FBXO2 FBXO33 FBXO33 FBXL7 FBXL7 ENSBTAP00000058621 ENSBTAP00000058621 FBXL17 FBXL17 FBXO31 FBXO31 FBXL2 FBXL2 FBH1 FBH1 LOC780968 LOC780968 ENSBTAP00000062219 ENSBTAP00000062219 FBXL19 FBXL19 LOC508086 LOC508086 ENSBTAP00000063926 ENSBTAP00000063926 CUL1 CUL1 ENSBTAP00000064354 ENSBTAP00000064354 FBXW7 FBXW7 ENSBTAP00000065568 ENSBTAP00000065568 ENSBTAP00000065570 ENSBTAP00000065570 ENSBTAP00000065941 ENSBTAP00000065941 FBXW11 FBXW11 FBXL3 FBXL3 F1MKA7_BOVIN F1MKA7_BOVIN BTRC BTRC FBXO9 FBXO9 FBXO42 FBXO42 TMEM183A TMEM183A FBXL15 FBXL15 FBXL21 FBXL21 CKS2 CKS2 FBXL6 FBXL6 LOC789309 LOC789309 FBXO25 FBXO25 ENSBTAP00000068449 ENSBTAP00000068449 ENSBTAP00000069011 ENSBTAP00000069011 FBXO6 FBXO6 FBXO17 FBXO17 RBX1 RBX1 ENSBTAP00000069485 ENSBTAP00000069485 FBXL22 FBXL22 ZC3HC1 ZC3HC1 FBXO41 FBXO41 SKP2 SKP2 FBXO4 FBXO4 USP47 USP47 FBXW5 FBXW5 ENSBTAP00000072606 ENSBTAP00000072606 ENSBTAP00000072193 ENSBTAP00000072193 FBXO25-2 FBXO25-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSBTAP00000070818Reverse transcriptase domain-containing protein. (563 aa)
ENSBTAP00000070247Uncharacterized protein. (207 aa)
FBXL5F-box/LRR-repeat protein 5; Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued (By similarity). (691 aa)
CKS1BCyclin-dependent kinases regulatory subunit 1; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function; Belongs to the CKS family. (79 aa)
CCNFCyclin-F; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. Belongs to the cyclin family. Cyclin AB subfamily. (1215 aa)
SKP1S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (163 aa)
LOC525426F-box domain-containing protein. (621 aa)
G3N0Q3_BOVINCULLIN_2 domain-containing protein; Belongs to the cullin family. (767 aa)
ENSBTAP00000056926Uncharacterized protein. (52 aa)
ENSBTAP00000057099Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (89 aa)
FBXL14F-box/LRR-repeat protein 14; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1 (By similarity). (474 aa)
FBXO2F-box only protein 2; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotransl [...] (297 aa)
FBXO33F-box protein 33. (560 aa)
FBXL7F-box and leucine rich repeat protein 7. (444 aa)
ENSBTAP00000058621Reverse transcriptase domain-containing protein. (571 aa)
FBXL17F-box and leucine rich repeat protein 17. (675 aa)
FBXO31F-box protein 31. (529 aa)
FBXL2F-box/LRR-repeat protein 2; Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degrad [...] (433 aa)
FBH1F-box DNA helicase 1. (1067 aa)
LOC780968RING-type domain-containing protein. (108 aa)
ENSBTAP00000062219Reverse transcriptase domain-containing protein. (488 aa)
FBXL19F-box and leucine rich repeat protein 19. (1020 aa)
LOC508086Uncharacterized protein. (309 aa)
ENSBTAP00000063926Reverse transcriptase domain-containing protein. (534 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
ENSBTAP00000064354Reverse transcriptase domain-containing protein. (543 aa)
FBXW7F-box/WD repeat-containing protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (By similarity). Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. Acts as a negative regulator of JNK si [...] (706 aa)
ENSBTAP00000065568Uncharacterized protein. (216 aa)
ENSBTAP00000065570Reverse transcriptase domain-containing protein. (568 aa)
ENSBTAP00000065941Reverse transcriptase domain-containing protein. (544 aa)
FBXW11F-box and WD repeat domain containing 11. (563 aa)
FBXL3F-box and leucine rich repeat protein 3. (321 aa)
F1MKA7_BOVINUncharacterized protein. (280 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (569 aa)
FBXO9F-box only protein 9; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTOR [...] (437 aa)
FBXO42F-box protein 42. (717 aa)
TMEM183ATransmembrane protein 183. (376 aa)
FBXL15F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity); Belongs to the FBXL15 family. (335 aa)
FBXL21F-box/LRR-repeat protein 21; Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock r [...] (434 aa)
CKS2Cyclin-dependent kinases regulatory subunit 2; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function; Belongs to the CKS family. (79 aa)
FBXL6F-box and leucine rich repeat protein 6. (534 aa)
LOC789309Uncharacterized protein. (279 aa)
FBXO25F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity). (391 aa)
ENSBTAP00000068449Reverse transcriptase domain-containing protein. (424 aa)
ENSBTAP00000069011Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (80 aa)
FBXO6F-box only protein 6; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high- mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved i [...] (329 aa)
FBXO17FBXO17 protein. (140 aa)
RBX1RING-type domain-containing protein. (261 aa)
ENSBTAP00000069485Reverse transcriptase domain-containing protein. (512 aa)
FBXL22F-box and leucine-rich protein 22; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC) (By similarity). (284 aa)
ZC3HC1Zinc finger, C3HC-type containing 1. (502 aa)
FBXO41F-box protein 41. (863 aa)
SKP2SKP2 protein. (424 aa)
FBXO4F-box only protein 4; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (By similarity). (387 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1375 aa)
FBXW5F-box and WD repeat domain containing 5. (670 aa)
ENSBTAP00000072606Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
ENSBTAP00000072193Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (80 aa)
FBXO25-2Uncharacterized protein. (220 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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