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| | DNM3 | Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (869 aa) |
| | CDKL5 | Cyclin dependent kinase like 5. (960 aa) |
| | RGS12 | PDZ domain-containing protein. (720 aa) |
| | PPP1R1B | Protein phosphatase 1 regulatory subunit 1B; Inhibitor of protein-phosphatase 1. (203 aa) |
| | ABI3BP | Fibronectin type-III domain-containing protein. (386 aa) |
| | ENSBTAP00000072547 | Uncharacterized protein. (135 aa) |
| | ENSBTAP00000072533 | Uncharacterized protein. (100 aa) |
| | PPP1R9A | Protein phosphatase 1 regulatory subunit 9A. (1342 aa) |
| | FRMPD1 | FERM and PDZ domain containing 1. (1587 aa) |
| | SARM1 | Sterile alpha and TIR motif containing 1. (728 aa) |
| | VSTM5 | V-set and transmembrane domain containing 5. (200 aa) |
| | ABHD13 | Abhydrolase domain containing 13. (337 aa) |
| | MME | Membrane metalloendopeptidase. (750 aa) |
| | CPNE6 | Copine-6; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner. Plays a role in dendrite formation by melanocytes; Belongs to the copine family. (557 aa) |
| | GPR179 | G protein-coupled receptor 179. (2354 aa) |
| | NRGN | NEUG(55-78); Acts as a 'third messenger' substrate of protein kinase C- mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium; Belongs to the neurogranin family. (78 aa) |
| | CALB2 | Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons. (271 aa) |
| | NSG2 | Neuronal vesicle trafficking-associated protein 2. (171 aa) |
| | EPS8 | Epidermal growth factor receptor pathway substrate 8. (838 aa) |
| | FARP1 | FERM, ARH/RhoGEF and pleckstrin domain protein 1. (1046 aa) |
| | ZFYVE27 | Protrudin; Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity. Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. Acts as an adapter protein that facilitates the interaction of KIF5A with VAPA, VAPB, [...] (417 aa) |
| | MAP1A | Microtubule associated protein 1A. (3122 aa) |
| | ENSBTAP00000070595 | C2 domain-containing protein. (150 aa) |
| | KIF1A | Kinesin family member 1A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1804 aa) |
| | NEURL1 | Neuralized E3 ubiquitin protein ligase 1. (574 aa) |
| | SEZ6 | Seizure protein 6 homolog; May play a role in cell-cell recognition and in neuronal membrane signaling. Seems to be important for the achievement of the necessary balance between dendrite elongation and branching during the elaboration of a complex dendritic arbor. Involved in the development of appropriate excitatory synaptic connectivity (By similarity). Belongs to the SEZ6 family. (986 aa) |
| | LOC527981 | Uncharacterized protein. (1912 aa) |
| | GRID2IP | Grid2 interacting protein. (1210 aa) |
| | TANC2 | Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2. (1989 aa) |
| | LRP2 | LDL receptor related protein 2. (4622 aa) |
| | GRIA2 | Glutamate ionotropic receptor AMPA type subunit 2. (883 aa) |
| | BAG2 | BAG family molecular chaperone regulator 2; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. (211 aa) |
| | DHX36 | ATP-dependent DNA/RNA helicase DHX36; Multifunctional ATP-dependent helicase that unwinds G- quadruplex (G4) structures. Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses (By similarity). G4 structures correspond to helical structures containing guanine tetrads. Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-ADN and G4- RNA) (By similarity). Plays a role in genomic integrity. Converts the G4-RNA structure present in telomerase RNA template componen [...] (1010 aa) |
| | PALMD | Palmdelphin. (550 aa) |
| | L1CAM | L1 cell adhesion molecule. (1395 aa) |
| | FXR1 | Fragile X mental retardation syndrome-related protein 1; RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs (By similarity). (648 aa) |
| | LZTS1 | Leucine zipper tumor suppressor 1. (595 aa) |
| | FXR2 | FMR1 autosomal homolog 2. (673 aa) |
| | ENSBTAP00000068052 | Uncharacterized protein. (68 aa) |
| | ENSBTAP00000068022 | Copine domain-containing protein. (108 aa) |
| | FAM151B | Family with sequence similarity 151 member B. (281 aa) |
| | NSG1 | Neuronal vesicle trafficking associated 1. (185 aa) |
| | GPHN | Gephyrin. (828 aa) |
| | NSMF | NMDA receptor synaptonuclear signaling and neuronal migration factor. (385 aa) |
| | OPHN1 | Oligophrenin 1. (803 aa) |
| | NOS1 | Nitric oxide synthase; Produces nitric oxide (NO). (1359 aa) |
| | NR1D1 | Nuclear receptor subfamily 1 group D member 1; Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARTNL/BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for [...] (630 aa) |
| | BCR | BCR activator of RhoGEF and GTPase. (1073 aa) |
| | COBL | Cordon-bleu WH2 repeat protein. (1308 aa) |
| | ENSBTAP00000064443 | Uncharacterized protein. (174 aa) |
| | CPLX2 | Complexin-2; Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis. Belongs to the complexin/synaphin family. (179 aa) |
| | SLC4A10 | Sodium-driven chloride bicarbonate exchanger; Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH (By similarity). Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (By similarity). Has also been shown to act as a sodium/biocarbonate cotransporter which does not couple net influx of bicarbonate to net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange (By similarity). Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid (By similar [...] (1117 aa) |
| | KIRREL3 | Kirre like nephrin family adhesion molecule 3. (745 aa) |
| | DBN1 | Drebrin 1. (726 aa) |
| | CNIH3 | Uncharacterized protein. (190 aa) |
| | CTTNBP2 | Cortactin binding protein 2. (1664 aa) |
| | SYNDIG1 | Synapse differentiation-inducing gene protein 1; May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation. (264 aa) |
| | ARFGEF2 | ADP ribosylation factor guanine nucleotide exchange factor 2. (1779 aa) |
| | CNIH2 | Cornichon family AMPA receptor auxiliary protein 2. (175 aa) |
| | CAPN2 | Calpain-2 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs. (703 aa) |
| | SGCE | Epsilon-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. (486 aa) |
| | KIF5A | Kinesin family member 5A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1039 aa) |
| | STUM | Stum, mechanosensory transduction mediator homolog. (198 aa) |
| | DTNBP1 | Dysbindin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role i [...] (352 aa) |
| | ABR | Active breakpoint cluster region-related protein; Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GD [...] (1195 aa) |
| | FMR1 | Fragile X mental retardation 1. (632 aa) |
| | SRGAP2 | Uncharacterized protein. (1071 aa) |
| | MAPK8IP3 | Mitogen-activated protein kinase 8 interacting protein 3. (1334 aa) |
| | ARHGAP42 | Rho GTPase activating protein 42. (874 aa) |
| | ENSBTAP00000057739 | RGS domain-containing protein. (217 aa) |
| | PSEN2 | Presenilin-2 CTF subunit; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the other members of the gamma- secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement o [...] (449 aa) |
| | LOC101901895 | SLIT and NTRK-like protein 2. (844 aa) |
| | SLC32A1 | Solute carrier family 32 member 1. (526 aa) |
| | SLITRK2 | SLIT and NTRK like family member 2. (844 aa) |
| | AVPR2 | Vasopressin V2 receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption (By similarity). (370 aa) |
| | LOC100295750 | Transmembrane protein 60. (133 aa) |
| | NTF4 | Neurotrophin 4; Belongs to the NGF-beta family. (210 aa) |
| | NF1 | Neurofibromin 1. (580 aa) |
| | DRD1 | D(1A) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. (446 aa) |
| | TMEM185A | Transmembrane protein 185A. (414 aa) |
| | LAMP5 | Lysosome-associated membrane glycoprotein 5; Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain. (280 aa) |
| | RGS14 | Regulator of G protein signaling 14. (565 aa) |
| | PDE4B | Phosphodiesterase. (721 aa) |
| | INPP5A | Inositol polyphosphate-5-phosphatase A. (412 aa) |
| | OTP | Orthopedia homeobox. (325 aa) |
| | SEPTIN14 | Septin-14; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). (432 aa) |
| | EPHA4 | EPH receptor A4. (986 aa) |
| | TMEM222 | Transmembrane protein 222. (157 aa) |
| | CPNE4 | Copine 4. (191 aa) |
| | KPNA1 | Importin subunit alpha-5, N-terminally processed; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and impo [...] (538 aa) |
| | TRPC2 | Short transient receptor potential channel 2 homolog; Thought to form a receptor-activated calcium permeant cation channel; Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC2 sub-subfamily. (1262 aa) |
| | F1MHW1_BOVIN | Uncharacterized protein. (623 aa) |
| | GRIP2 | Glutamate receptor interacting protein 2. (1046 aa) |
| | SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1. (1085 aa) |
| | CDX1 | CDX1 protein. (265 aa) |
| | CPNE7 | Copine 7. (549 aa) |
| | ZNF804A | Zinc finger protein 804A. (1073 aa) |
| | PRKCG | Protein kinase C gamma type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing p [...] (771 aa) |
| | SYNPO | Synaptopodin. (1128 aa) |
| | KLHL17 | Kelch like family member 17. (643 aa) |
| | URAD | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase; Catalyzes the stereoselective decarboxylation of 2-oxo-4- hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin. (170 aa) |
| | GIGYF2 | GRB10 interacting GYF protein 2. (1291 aa) |
| | AMIGO1 | Adhesion molecule with Ig like domain 1. (493 aa) |
| | ADCY8 | Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1253 aa) |
| | NPAS4 | Neuronal PAS domain protein 4. (798 aa) |
| | PTRHD1 | Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa) |
| | PDLIM4 | PDZ and LIM domain protein 4; Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle. Involved in reorganization of the actin cytoskeleton (By similarity). In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transpo [...] (331 aa) |
| | MYO1D | Unconventional myosin-Id; Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes (By similarity). Required for normal planar cell polarity in ciliated tracheal cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement in the trachea. Required for normal, polarized cilia organization in brain ependymal epithelial cells (By similarity). (1006 aa) |
| | CRIPT | Cysteine-rich PDZ-binding protein; Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses. (101 aa) |
| | CALB1 | Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. (261 aa) |
| | DNER | Delta/notch like EGF repeat containing. (727 aa) |
| | RUFY3 | RUN and FYVE domain containing 3. (504 aa) |
| | SST | Somatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin. (116 aa) |
| | TAOK2 | TAO kinase 2. (1049 aa) |
| | MAPT | Microtubule-associated protein. (617 aa) |
| | RBM3 | RNA binding motif protein 3. (160 aa) |
| | MAP2 | Microtubule-associated protein. (2008 aa) |
| | PVALB | Parvalbumin alpha; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity). (110 aa) |
| | OPRM1 | Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP- bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell ty [...] (401 aa) |
| | CRHBP | Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (324 aa) |
| | TBR1 | T-box brain transcription factor 1. (682 aa) |
| | CCIN | Calicin; Possible morphogenic cytoskeletal element in spermiogenic differentiation. (588 aa) |
| | ARHGAP44 | Rho GTPase activating protein 44. (836 aa) |
| | PTPRO | Protein tyrosine phosphatase receptor type O. (1214 aa) |
| | SOD1 | Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (152 aa) |
| | ADCY3 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa) |
| | NCDN | Neurochondrin; Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth (By similarity); Belongs to t [...] (729 aa) |
| | SIPA1L1 | Signal induced proliferation associated 1 like 1. (1805 aa) |
| | CADM1 | Cell adhesion molecule 1. (417 aa) |
| | DOCK10 | Dedicator of cytokinesis 10; Belongs to the DOCK family. (2199 aa) |
| | F1MNQ4_BOVIN | Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (152 aa) |
| | NTF3 | Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (253 aa) |
| | PSEN1 | Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] (478 aa) |
| | LRP4 | Low density lipoprotein receptor-related protein 4. (1905 aa) |
| | ARHGEF15 | Rho guanine nucleotide exchange factor 15. (847 aa) |
| | KCND3 | Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family. (655 aa) |
| | TRIM9 | E3 ubiquitin-protein ligase TRIM9; E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation. (795 aa) |
| | KCND2 | Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (630 aa) |
| | APOD | Apolipoprotein D; APOD occurs in the macromolecular complex with lecithin- transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts (By similarity). (212 aa) |
| | TMEM60 | Transmembrane protein 60. (133 aa) |
| | TMEM185B | Transmembrane protein 185B. (350 aa) |
| | KCNB2 | Potassium voltage-gated channel subfamily B member 2; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric an [...] (911 aa) |
| | CDK5R1 | Cyclin-dependent kinase 5 activator 1, p25; p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution (By sim [...] (307 aa) |
| | ALS2 | Alsin Rho guanine nucleotide exchange factor ALS2. (1656 aa) |
