(30 nodes) Cortical actin cytoskeleton network (Bos taurus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	COBL	Cordon-bleu WH2 repeat protein. (1308 aa)
	ENSBTAP00000062365	Uncharacterized protein. (205 aa)
	KRT42	Keratin 42; Belongs to the intermediate filament family. (453 aa)
	SPTA1	Spectrin alpha, erythrocytic 1. (2411 aa)
	IQGAP3	IQ motif containing GTPase activating protein 3. (1635 aa)
	ANLN	Anillin actin binding protein. (1093 aa)
	PLEKHH2	Pleckstrin homology, MyTH4 and FERM domain containing H2. (1491 aa)
	CTTN	Cortactin. (538 aa)
	HCLS1	Hematopoietic cell-specific Lyn substrate 1. (485 aa)
	SPTB	Spectrin beta chain; Belongs to the spectrin family. (2331 aa)
	APMAP	Adipocyte plasma membrane-associated protein; Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation (By similarity); Belongs to the strictosidine synthase family. (412 aa)
	LANCL3	LanC like 3. (420 aa)
	LOC526149	Uncharacterized protein. (317 aa)
	CIB2	Calcium and integrin binding family member 2. (187 aa)
	RTKN	Rhotekin. (564 aa)
	SNX9	Sorting nexin. (617 aa)
	RTKN2	Rhotekin 2. (598 aa)
	P3H1	Prolyl 3-hydroxylase 1. (736 aa)
	LANCL2	LANCL2 protein. (433 aa)
	KRT14	Keratin, type I cytoskeletal 14; Belongs to the intermediate filament family. (515 aa)
	MYADM	Myeloid-associated differentiation marker. (322 aa)
	SLC2A1	Solute carrier family 2, facilitated glucose transporter member 1; Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. (492 aa)
	KNCN	Kinocilin. (101 aa)
	SPATA3	Spermatogenesis associated 3. (230 aa)
	ACTN1	Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). (914 aa)
	MOK	MOK protein kinase; Belongs to the protein kinase superfamily. (249 aa)
	ENSBTAP00000068994	Uncharacterized protein. (193 aa)
	MYO1A	Unconventional myosin-Ia; Involved in directing the movement of organelles along actin filaments; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1043 aa)
	AUH	Uncharacterized protein. (275 aa)
	ACTN2	Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity); Belongs to the alpha-actinin family. (897 aa)

Your Current Organism:

Bos taurus

NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTN1	CTTN	ENSBTAP00000073520	ENSBTAP00000007976	Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity).	Cortactin.	0.495
ACTN1	HCLS1	ENSBTAP00000073520	ENSBTAP00000001338	Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity).	Hematopoietic cell-specific Lyn substrate 1.	0.428
ANLN	IQGAP3	ENSBTAP00000043678	ENSBTAP00000043999	Anillin actin binding protein.	IQ motif containing GTPase activating protein 3.	0.628
ANLN	RTKN	ENSBTAP00000043678	ENSBTAP00000000619	Anillin actin binding protein.	Rhotekin.	0.417
APMAP	AUH	ENSBTAP00000005603	ENSBTAP00000067281	Adipocyte plasma membrane-associated protein; Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation (By similarity); Belongs to the strictosidine synthase family.	Uncharacterized protein.	0.412
APMAP	ENSBTAP00000068994	ENSBTAP00000005603	ENSBTAP00000068994	Adipocyte plasma membrane-associated protein; Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation (By similarity); Belongs to the strictosidine synthase family.	Uncharacterized protein.	0.412
AUH	APMAP	ENSBTAP00000067281	ENSBTAP00000005603	Uncharacterized protein.	Adipocyte plasma membrane-associated protein; Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation (By similarity); Belongs to the strictosidine synthase family.	0.412
CTTN	ACTN1	ENSBTAP00000007976	ENSBTAP00000073520	Cortactin.	Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity).	0.495
CTTN	HCLS1	ENSBTAP00000007976	ENSBTAP00000001338	Cortactin.	Hematopoietic cell-specific Lyn substrate 1.	0.934
CTTN	SNX9	ENSBTAP00000007976	ENSBTAP00000008296	Cortactin.	Sorting nexin.	0.511
ENSBTAP00000068994	APMAP	ENSBTAP00000068994	ENSBTAP00000005603	Uncharacterized protein.	Adipocyte plasma membrane-associated protein; Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation (By similarity); Belongs to the strictosidine synthase family.	0.412
HCLS1	ACTN1	ENSBTAP00000001338	ENSBTAP00000073520	Hematopoietic cell-specific Lyn substrate 1.	Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity).	0.428
HCLS1	CTTN	ENSBTAP00000001338	ENSBTAP00000007976	Hematopoietic cell-specific Lyn substrate 1.	Cortactin.	0.934
HCLS1	SNX9	ENSBTAP00000001338	ENSBTAP00000008296	Hematopoietic cell-specific Lyn substrate 1.	Sorting nexin.	0.500
IQGAP3	ANLN	ENSBTAP00000043999	ENSBTAP00000043678	IQ motif containing GTPase activating protein 3.	Anillin actin binding protein.	0.628
IQGAP3	RTKN	ENSBTAP00000043999	ENSBTAP00000000619	IQ motif containing GTPase activating protein 3.	Rhotekin.	0.492
RTKN	ANLN	ENSBTAP00000000619	ENSBTAP00000043678	Rhotekin.	Anillin actin binding protein.	0.417
RTKN	IQGAP3	ENSBTAP00000000619	ENSBTAP00000043999	Rhotekin.	IQ motif containing GTPase activating protein 3.	0.492
SNX9	CTTN	ENSBTAP00000008296	ENSBTAP00000007976	Sorting nexin.	Cortactin.	0.511
SNX9	HCLS1	ENSBTAP00000008296	ENSBTAP00000001338	Sorting nexin.	Hematopoietic cell-specific Lyn substrate 1.	0.500

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