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CLIC3 CLIC3 BEST4 BEST4 CLCN7 CLCN7 GLRA4 GLRA4 GRM3 GRM3 GLRB GLRB CPXM1 CPXM1 BEST1 BEST1 CLCNKA CLCNKA CLIC4 CLIC4 CLIC1 CLIC1 TTYH2 TTYH2 CLIC2 CLIC2 CLCN1 CLCN1 BEST2 BEST2 BEST3 BEST3 OSTM1 OSTM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CLIC3Chloride intracellular channel 3. (237 aa)
BEST4Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (467 aa)
CLCN7H(+)/Cl(-) exchange transporter 7; Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 7/CLCN7 subfamily. (809 aa)
GLRA4Glycine receptor alpha 4; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (342 aa)
GRM3Glutamate metabotropic receptor 3. (879 aa)
GLRBGlycine receptor subunit beta; Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. (497 aa)
CPXM1Carboxypeptidase X, M14 family member 1. (819 aa)
BEST1Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (589 aa)
CLCNKAChloride channel protein. (687 aa)
CLIC4Chloride intracellular channel protein 4; Can insert into membranes and form chloride ion channels. (253 aa)
CLIC1Chloride intracellular channel protein 1; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions (By similarity). (241 aa)
TTYH2Protein tweety homolog; Probable chloride channel; Belongs to the tweety family. (533 aa)
CLIC2Chloride intracellular channel 2. (247 aa)
CLCN1Chloride channel protein. (964 aa)
BEST2Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (512 aa)
BEST3Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (626 aa)
OSTM1Osteoclastogenesis associated transmembrane protein 1. (345 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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