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| | RIN1 | Ras and Rab interactor 1. (857 aa) |
| | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity). (1291 aa) |
| | SOCS6 | Suppressor of cytokine signaling 6. (444 aa) |
| | GRB7 | Growth factor receptor-bound protein 7; Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phos [...] (532 aa) |
| | HSH2D | Hematopoietic SH2 domain containing. (342 aa) |
| | SHC2 | SHC adaptor protein 2. (584 aa) |
| | VAV3 | Vav guanine nucleotide exchange factor 3. (845 aa) |
| | SH2D3C | SH2 domain containing 3C. (860 aa) |
| | GRAP2 | GRB2 related adaptor protein 2. (316 aa) |
| | ABL2 | Tyrosine-protein kinase. (1182 aa) |
| | JAK2 | Tyrosine-protein kinase. (1132 aa) |
| | FYN | Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] (537 aa) |
| | SHC4 | Uncharacterized protein. (630 aa) |
| | SHC3 | SHC adaptor protein 3. (583 aa) |
| | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] (724 aa) |
| | RIN3 | Ras and Rab interactor 3. (1011 aa) |
| | SH2B2 | SH2B adaptor protein 2. (648 aa) |
| | RASA1 | Ras GTPase-activating protein 1; Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21. (1044 aa) |
| | LCP2 | Lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa). (532 aa) |
| | SOCS5 | Suppressor of cytokine signaling 5; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5- SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T- helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes diff [...] (536 aa) |
| | SRC | Tyrosine-protein kinase. (688 aa) |
| | SOCS7 | Suppressor of cytokine signaling 7. (642 aa) |
| | SOCS3 | Suppressor of cytokine signaling 3; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin and leptin receptors. Inhibits JAK2 kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Proba [...] (229 aa) |
| | TNS4 | Tensin-4; May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton May promote apoptosis, via its cleavage by caspase-3. Cytoplasm, cytoskeleton. (716 aa) |
| | DAPP1 | Dual adaptor of phosphotyrosine and 3-phosphoinositides 1. (280 aa) |
| | STAT6 | Signal transducer and activator of transcription. (847 aa) |
| | ZAP70 | Tyrosine-protein kinase. (617 aa) |
| | CRK | CRK proto-oncogene, adaptor protein. (304 aa) |
| | GRB2 | Growth factor receptor-bound protein 2. (217 aa) |
| | SOCS1 | Suppressor of cytokine signaling 1. (223 aa) |
| | STAT2 | Signal transducer and activator of transcription. (857 aa) |
| | SH2D4B | SH2 domain containing 4B. (403 aa) |
| | JAK1 | Tyrosine-protein kinase. (1158 aa) |
| | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma; Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. (461 aa) |
| | FES | Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa) |
| | STAT5B | Signal transducer and activator of transcription 5B; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. (787 aa) |
| | SLA | Src like adaptor. (308 aa) |
| | CSK | Tyrosine-protein kinase CSK; Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C- terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins [...] (450 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1264 aa) |
| | VAV2 | Vav guanine nucleotide exchange factor 2. (839 aa) |
| | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta; Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein- tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating t [...] (724 aa) |
| | PTPN11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa) |
| | SRMS | Tyrosine-protein kinase. (494 aa) |
| | YES1 | Tyrosine-protein kinase. (541 aa) |
| | SH2D4A | SH2 domain containing 4A. (450 aa) |
| | SH2D5 | SH2 domain containing 5. (428 aa) |
| | STAP1 | Signal transducing adaptor family member 1. (288 aa) |
| | BMX | Tyrosine-protein kinase. (651 aa) |
| | NCK2 | Cytoplasmic protein. (376 aa) |
| | BLNK | B cell linker. (501 aa) |
| | SH2B3 | SH2B adaptor protein 3. (628 aa) |
| | SHF | Src homology 2 domain containing F. (488 aa) |
| | SYK | Tyrosine-protein kinase. (628 aa) |
| | ENSBTAP00000070075 | SH2 domain-containing protein. (189 aa) |
| | FGR | Tyrosine-protein kinase. (527 aa) |
| | SOCS2 | Suppressor of cytokine signaling 2; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). (202 aa) |
| | TXK | Tyrosine-protein kinase. (527 aa) |
| | SH3BP2 | SH3 domain binding protein 2. (636 aa) |
| | RIN2 | Ras and Rab interactor 2. (909 aa) |
| | BCAR3 | Breast cancer anti-estrogen resistance protein 3 homolog; Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (By similarity). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (By similarity). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1. Inhibits cell migration and [...] (827 aa) |
| | TNS2 | Tensin 2. (1427 aa) |
| | STAT1 | Signal transducer and activator of transcription. (817 aa) |
| | PTPN6 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa) |
| | SH2D1B | SH2 domain-containing protein. (133 aa) |
| | TNS3 | Tensin 3. (1595 aa) |
| | SH2D3A | SH2 domain containing 3A. (575 aa) |
| | SUPT6H | Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1729 aa) |
| | MATK | Tyrosine-protein kinase. (485 aa) |
| | HCK | Tyrosine-protein kinase. (558 aa) |
| | TNS1 | Tensin-1; Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton. (1883 aa) |
| | INPP5D | Inositol polyphosphate-5-phosphatase D. (1319 aa) |
| | ABL1 | Tyrosine-protein kinase. (1151 aa) |
| | GRB10 | Growth factor receptor bound protein 10. (598 aa) |
| | BLK | Tyrosine-protein kinase. (524 aa) |
| | CRKL | CRK like proto-oncogene, adaptor protein. (302 aa) |
| | SH2D7 | SH2 domain containing 7. (454 aa) |
| | SHD | Src homology 2 domain containing transforming protein D. (341 aa) |
| | PTK6 | Tyrosine-protein kinase. (450 aa) |
| | FER | Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa) |
| | VAV1 | Proto-oncogene vav; Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. (844 aa) |
| | TEC | Tyrosine-protein kinase. (445 aa) |
| | SH2D2A | SH2 domain containing 2A. (418 aa) |
| | GRAP | GRB2-related adapter protein; Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. Plays a role in the inner ear and in hearing. (217 aa) |
| | LCK | Tyrosine-protein kinase. (509 aa) |
| | SH2D1A | SH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Ca [...] (128 aa) |
| | ITK | Tyrosine-protein kinase. (620 aa) |
| | STAT5A | Signal transducer and activator of transcription 5A; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation (By similarity). (799 aa) |
| | SHB | SH2 domain containing adaptor protein B. (507 aa) |
| | LOC526769 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (613 aa) |
| | CISH | Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation (By similarity). May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subs [...] (254 aa) |
| | STAT4 | Signal transducer and activator of transcription. (751 aa) |
| | BTK | Tyrosine-protein kinase. (659 aa) |
| | SOCS4 | Suppressor of cytokine signaling 4; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate- recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR (By similarity). (440 aa) |
| | STAT3 | Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] (770 aa) |
| | CHN2 | Chimaerin; GTPase-activating protein for p21-rac. (468 aa) |
| | JAK3 | Tyrosine-protein kinase. (1104 aa) |
| | SHE | Src homology 2 domain containing E. (522 aa) |
| | LYN | Tyrosine-protein kinase. (512 aa) |
| | FRK | Tyrosine-protein kinase. (514 aa) |
| | SHC1 | SHC-transforming protein 1; Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity). (583 aa) |
| | SLA2 | Src-like-adaptor 2 isoform a. (276 aa) |
| | GRB14 | Growth factor receptor-bound protein 14; Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal (By similarity); Belongs to the GRB7/10/14 family. (540 aa) |
| | SH2B1 | SH2B adaptor protein 1. (756 aa) |
| | INPPL1 | Inositol polyphosphate phosphatase like 1. (1264 aa) |
| | NCK1 | Cytoplasmic protein. (377 aa) |
