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BMP2 BMP2 GDF7 GDF7 F1MKJ7_BOVIN F1MKJ7_BOVIN BMP4 BMP4 LOC100336971 LOC100336971 GDF10 GDF10 BMP10 BMP10 NRTN NRTN LEFTY2 LEFTY2 GDF6 GDF6 GDF15 GDF15 AMH AMH NODAL NODAL BMP5 BMP5 TGFB3 TGFB3 MSTN MSTN INHA INHA GDF9 GDF9 GDF3 GDF3 PSPN PSPN GDF1 GDF1 BMP6 BMP6 INHBC INHBC GDF11 GDF11 BMP8A BMP8A ARTN ARTN BMP3 BMP3 BMP7 BMP7 TGFB1 TGFB1 TGFB2 TGFB2 INHBB INHBB GDF5 GDF5 GDF2 GDF2 BMP8B BMP8B BMP15 BMP15 INHBA INHBA INHBE INHBE GDNF GDNF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMP2Bone morphogenetic protein 2. (395 aa)
GDF7Growth differentiation factor 7. (450 aa)
F1MKJ7_BOVINTGF_BETA_2 domain-containing protein. (364 aa)
BMP4Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
LOC100336971Left-right determination factor. (367 aa)
GDF10Growth/differentiation factor 10; Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis. (478 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
NRTNNeurturin. (197 aa)
LEFTY2Left-right determination factor. (367 aa)
GDF6Growth/differentiation factor 6; Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal- ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-speci [...] (470 aa)
GDF15Growth differentiation factor 15. (308 aa)
AMHMuellerian-inhibiting factor; This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin; Belongs to the TGF-beta family. (575 aa)
NODALNodal growth differentiation factor. (346 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
MSTNGrowth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth. (375 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins; Belongs to the TGF-beta family. (360 aa)
GDF9Growth/differentiation factor 9; Required for ovarian folliculogenesis. (453 aa)
GDF3TGF_BETA_2 domain-containing protein. (364 aa)
PSPNPersephin. (153 aa)
GDF1Growth differentiation factor 1. (369 aa)
BMP6Bone morphogenetic protein 6. (496 aa)
INHBCInhibin subunit beta C. (352 aa)
GDF11Growth differentiation factor 11. (406 aa)
BMP8ATGF_BETA_2 domain-containing protein. (405 aa)
ARTNArtemin. (230 aa)
BMP3Bone morphogenetic protein 3; Induces cartilage and bone formation. (475 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (499 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (442 aa)
INHBBInhibin beta B chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (408 aa)
GDF5Growth differentiation factor 5. (499 aa)
GDF2Growth differentiation factor 2. (431 aa)
BMP8BTGF_BETA_2 domain-containing protein. (405 aa)
BMP15Bone morphogenetic protein 15; May be involved in follicular development. Seems to be an oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity). (394 aa)
INHBAInhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (425 aa)
INHBEInhibin subunit beta E. (348 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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