(35 nodes) Glutathione S-transferase, C-terminal-like network (Bos taurus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GSTA2	Glutathione S-transferase A2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. (223 aa)
	GSTA1	Glutathione S-transferase. (291 aa)
	E1BKD8_BOVIN	Uncharacterized protein. (224 aa)
	GDAP1L1	Ganglioside-induced differentiation-associated protein 1-like 1. (367 aa)
	GSTA3	Glutathione S-transferase, alpha 3. (222 aa)
	ENSBTAP00000073566	Uncharacterized protein. (244 aa)
	GSTM3	Glutathione S-transferase. (240 aa)
	GSTP1-2	Glutathione S-transferase P; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity); Belongs to the GST superfamily. Pi family. (240 aa)
	GSTM1-2	Uncharacterized protein. (266 aa)
	GSTA4	Glutathione S-transferase A4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Alpha family. (303 aa)
	GSTT2	Uncharacterized protein; Belongs to the GST superfamily. (281 aa)
	GSTZ1	Glutathione S-transferase zeta 1; Belongs to the GST superfamily. (445 aa)
	EPRS1	Glutamyl-prolyl-tRNA synthetase. (1518 aa)
	GSTP1	Glutathione S-transferase P; Belongs to the GST superfamily. (191 aa)
	GSTO2	Glutathione S-transferase omega 2; Belongs to the GST superfamily. (244 aa)
	GSTO1	Uncharacterized protein; Belongs to the GST superfamily. (241 aa)
	GSTT1	Glutathione S-transferase theta-1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Also binds steroids, bilirubin, carcinogens and numerous organic anions. Has dichloromethane dehalogenase activity; Belongs to the GST superfamily. Theta family. (240 aa)
	GSTT4	Uncharacterized protein; Belongs to the GST superfamily. (241 aa)
	CLIC6	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (655 aa)
	VARS1	Valyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (1264 aa)
	CLIC2	Chloride intracellular channel 2. (247 aa)
	EEF1G	Elongation factor 1-gamma; Probably plays a role in anchoring the complex to other cellular components. (440 aa)
	GDAP1	Ganglioside-induced differentiation-associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission; Belongs to the GST superfamily. (358 aa)
	LOC100295687	Glutathione S-transferase Mu 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Protects against the thiol-mediated metal-catalysed oxidative inactivation of enzymes. Belongs to the GST superfamily. Mu family. (218 aa)
	LOC785216	Uncharacterized protein. (344 aa)
	CLIC1	Chloride intracellular channel protein 1; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions (By similarity). (241 aa)
	GSTM1	Glutathione S-transferase Mu 1; Belongs to the GST superfamily. (218 aa)
	HPGDS	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. (199 aa)
	GSTA5	Glutathione S-transferase. (222 aa)
	EEF1E1	Eukaryotic translation elongation factor 1 epsilon 1. (174 aa)
	MARS1	Methionine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Plays a role in the synthesis of ribosomal RNA in the nucleolus; Belongs to the class-I aminoacyl-tRNA synthetase family. (906 aa)
	CLIC5	Chloride intracellular channel protein 5; Required for normal hearing. It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti. Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture. Plays a role in formation of the lens suture in the eye, which is important for normal optical propert [...] (467 aa)
	PTGES2	Prostaglandin E synthase 2 truncated form; Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2); Belongs to the GST superfamily. (431 aa)
	G3N3V2_BOVIN	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (137 aa)
	CLIC4	Chloride intracellular channel protein 4; Can insert into membranes and form chloride ion channels. (253 aa)

Your Current Organism:

Bos taurus

NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLIC1	CLIC4	ENSBTAP00000017995	ENSBTAP00000048950	Chloride intracellular channel protein 1; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions (By similarity).	Chloride intracellular channel protein 4; Can insert into membranes and form chloride ion channels.	0.404
CLIC2	CLIC4	ENSBTAP00000014537	ENSBTAP00000048950	Chloride intracellular channel 2.	Chloride intracellular channel protein 4; Can insert into membranes and form chloride ion channels.	0.626
CLIC2	CLIC5	ENSBTAP00000014537	ENSBTAP00000057011	Chloride intracellular channel 2.	Chloride intracellular channel protein 5; Required for normal hearing. It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti. Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture. Plays a role in formation of the lens suture in the eye, which is important for normal optical propert [...]	0.454
CLIC2	CLIC6	ENSBTAP00000014537	ENSBTAP00000002299	Chloride intracellular channel 2.	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family.	0.439
CLIC2	G3N3V2_BOVIN	ENSBTAP00000014537	ENSBTAP00000056615	Chloride intracellular channel 2.	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family.	0.432
CLIC4	CLIC1	ENSBTAP00000048950	ENSBTAP00000017995	Chloride intracellular channel protein 4; Can insert into membranes and form chloride ion channels.	Chloride intracellular channel protein 1; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions (By similarity).	0.404
CLIC4	CLIC2	ENSBTAP00000048950	ENSBTAP00000014537	Chloride intracellular channel protein 4; Can insert into membranes and form chloride ion channels.	Chloride intracellular channel 2.	0.626
CLIC4	CLIC5	ENSBTAP00000048950	ENSBTAP00000057011	Chloride intracellular channel protein 4; Can insert into membranes and form chloride ion channels.	Chloride intracellular channel protein 5; Required for normal hearing. It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti. Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture. Plays a role in formation of the lens suture in the eye, which is important for normal optical propert [...]	0.498
CLIC4	CLIC6	ENSBTAP00000048950	ENSBTAP00000002299	Chloride intracellular channel protein 4; Can insert into membranes and form chloride ion channels.	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family.	0.473
CLIC4	G3N3V2_BOVIN	ENSBTAP00000048950	ENSBTAP00000056615	Chloride intracellular channel protein 4; Can insert into membranes and form chloride ion channels.	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family.	0.472
CLIC4	GSTP1	ENSBTAP00000048950	ENSBTAP00000004615	Chloride intracellular channel protein 4; Can insert into membranes and form chloride ion channels.	Glutathione S-transferase P; Belongs to the GST superfamily.	0.433
CLIC4	GSTP1-2	ENSBTAP00000048950	ENSBTAP00000061249	Chloride intracellular channel protein 4; Can insert into membranes and form chloride ion channels.	Glutathione S-transferase P; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity); Belongs to the GST superfamily. Pi family.	0.433
CLIC5	CLIC2	ENSBTAP00000057011	ENSBTAP00000014537	Chloride intracellular channel protein 5; Required for normal hearing. It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti. Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture. Plays a role in formation of the lens suture in the eye, which is important for normal optical propert [...]	Chloride intracellular channel 2.	0.454
CLIC5	CLIC4	ENSBTAP00000057011	ENSBTAP00000048950	Chloride intracellular channel protein 5; Required for normal hearing. It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti. Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture. Plays a role in formation of the lens suture in the eye, which is important for normal optical propert [...]	Chloride intracellular channel protein 4; Can insert into membranes and form chloride ion channels.	0.498
CLIC6	CLIC2	ENSBTAP00000002299	ENSBTAP00000014537	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family.	Chloride intracellular channel 2.	0.439
CLIC6	CLIC4	ENSBTAP00000002299	ENSBTAP00000048950	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family.	Chloride intracellular channel protein 4; Can insert into membranes and form chloride ion channels.	0.473
E1BKD8_BOVIN	GSTA1	ENSBTAP00000035695	ENSBTAP00000068850	Uncharacterized protein.	Glutathione S-transferase.	0.408
E1BKD8_BOVIN	GSTA2	ENSBTAP00000035695	ENSBTAP00000043661	Uncharacterized protein.	Glutathione S-transferase A2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.	0.407
E1BKD8_BOVIN	GSTA4	ENSBTAP00000035695	ENSBTAP00000063570	Uncharacterized protein.	Glutathione S-transferase A4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Alpha family.	0.516
E1BKD8_BOVIN	GSTA5	ENSBTAP00000035695	ENSBTAP00000028674	Uncharacterized protein.	Glutathione S-transferase.	0.408

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