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| | S100A2 | Protein S100-A2; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth (By similarity). (97 aa) |
| | ACTN4 | Alpha-actinin-4; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions. May also function as a transcriptional coactivator, stimulating transcri [...] (1032 aa) |
| | PLCE1 | Phosphoinositide phospholipase C. (2297 aa) |
| | EPS15L1 | Epidermal growth factor receptor pathway substrate 15 like 1. (939 aa) |
| | TESC | Tescalcin. (264 aa) |
| | ENSBTAP00000070572 | Uncharacterized protein. (103 aa) |
| | PDCD6 | Programmed cell death 6. (191 aa) |
| | CAPNS1 | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. (290 aa) |
| | LPCAT4 | Lysophosphatidylcholine acyltransferase 4. (524 aa) |
| | SLC25A23 | Solute carrier family 25 member 23; Belongs to the mitochondrial carrier (TC 2.A.29) family. (496 aa) |
| | USP32 | Ubiquitin specific peptidase 32; Belongs to the peptidase C19 family. (1631 aa) |
| | NCALD | Neurocalcin-delta; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions. (193 aa) |
| | EFCAB7 | EF-hand calcium binding domain 7. (629 aa) |
| | CALM1 | Uncharacterized protein; Belongs to the calmodulin family. (150 aa) |
| | CABP1 | Calcium-binding protein 1; Modulates calcium-dependent activity of inositol 1,4,5- triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium- dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L- type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function. Suppresses the calcium-dependent inactivation of CACNA1D. Inhibits TRPC5 cha [...] (417 aa) |
| | CALU | Calumenin; Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma- carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity). (315 aa) |
| | RHOT1 | Mitochondrial Rho GTPase 1; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity). (720 aa) |
| | ANKEF1 | Ankyrin repeat and EF-hand domain containing 1. (776 aa) |
| | PPP2R3A | Protein phosphatase 2 regulatory subunit B''alpha. (1150 aa) |
| | ENSBTAP00000068440 | Uncharacterized protein. (202 aa) |
| | ENSBTAP00000068220 | Uncharacterized protein. (610 aa) |
| | EHD1 | EH domain-containing protein 1; ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth. Plays a role in myoblast fusion. Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing. Plays a role in the formation of the ciliary v [...] (534 aa) |
| | MCFD2 | Multiple coagulation factor deficiency 2. (335 aa) |
| | CBLC | Cbl proto-oncogene C. (491 aa) |
| | EFCAB8 | EF-hand calcium binding domain 8. (1232 aa) |
| | SLC25A12 | Solute carrier family 25 member 12; Belongs to the mitochondrial carrier (TC 2.A.29) family. (712 aa) |
| | S100A9 | Protein S100-A9; S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid [...] (156 aa) |
| | CAPN3 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. (822 aa) |
| | MYL3 | Myosin light chain 3; Regulatory light chain of myosin. Does not bind calcium. (262 aa) |
| | PPP2R3B | EF-hand domain-containing protein. (581 aa) |
| | PLCH2 | Phosphoinositide phospholipase C. (1400 aa) |
| | CAPSL | Calcyphosine like. (208 aa) |
| | CIB1 | Calcium and integrin-binding protein 1; Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin- mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulat [...] (201 aa) |
| | TCHH | EF-hand domain-containing protein. (1414 aa) |
| | ENSBTAP00000066314 | Uncharacterized protein. (533 aa) |
| | MYL2 | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...] (181 aa) |
| | SPOCK1 | Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (Testican) 1. (442 aa) |
| | HPCAL4 | Hippocalcin-like protein 4; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. (295 aa) |
| | KCNIP3 | Calsenilin; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity). (279 aa) |
| | MYLPF | Myosin regulatory light chain 2, skeletal muscle isoform. (170 aa) |
| | EFCAB11 | EF-hand calcium binding domain 11. (225 aa) |
| | KCNIP2 | Potassium voltage-gated channel interacting protein 2. (290 aa) |
| | ACTN2 | Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity); Belongs to the alpha-actinin family. (897 aa) |
| | SPARC | SPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity. (389 aa) |
| | GPD2 | Glycerol-3-phosphate dehydrogenase, mitochondrial. (727 aa) |
| | RPTN | Repetin. (1236 aa) |
| | S100A3 | S100 calcium binding protein A3. (129 aa) |
| | ENSBTAP00000064523 | Uncharacterized protein. (115 aa) |
| | WDR49 | WD repeat domain 49. (1035 aa) |
| | CIB4 | Calcium and integrin binding family member 4. (229 aa) |
| | SPEF2 | Sperm flagella 2 protein. (1713 aa) |
| | DEF6 | DEF6 guanine nucleotide exchange factor. (668 aa) |
| | PHF24 | PHD finger protein 24. (400 aa) |
| | VSNL1 | Visinin-like protein 1; Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner. (208 aa) |
| | PKD2L1 | Polycystin 2 like 1, transient receptor potential cation channel. (773 aa) |
| | S100A11 | Protein S100; Belongs to the S-100 family. (142 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1264 aa) |
| | S100A5 | Protein S100; Belongs to the S-100 family. (93 aa) |
| | NIN | Ninein. (2167 aa) |
| | DTNA | Dystrobrevin. (743 aa) |
| | ACTN1 | Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). (914 aa) |
| | KCNIP4 | Kv channel-interacting protein 4; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents (By similarity); Belongs to the recoverin family. (250 aa) |
| | LPCAT2 | Lysophosphatidylcholine acyltransferase 2. (531 aa) |
| | CIB2 | Calcium and integrin binding family member 2. (187 aa) |
| | EFCAB1 | EF-hand calcium-binding domain-containing protein 1. (212 aa) |
| | FSTL1 | Follistatin-related protein 1; May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity). (312 aa) |
| | CALM-2 | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). (149 aa) |
| | S100A8 | Protein S100-A8; S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH- oxidase. Activates NADPH-oxidase by facilitat [...] (89 aa) |
| | DMD | Uncharacterized protein. (1243 aa) |
| | MYL9 | Myosin regulatory light polypeptide 9. (172 aa) |
| | RASGRP3 | RAS guanyl releasing protein 3. (697 aa) |
| | S100B | Protein S100-B; Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic pr [...] (92 aa) |
| | HPCAL1 | Hippocalcin-like protein 1; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation; Belongs to the recoverin family. (193 aa) |
| | ENSBTAP00000063139 | Uncharacterized protein. (173 aa) |
| | CRNN | EF-hand domain-containing protein. (841 aa) |
| | EFHC2 | EF-hand domain containing 2. (733 aa) |
| | PKD2 | Polycystin-2; Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Can also form a functional, homotetrameric ion channel (By similarity). Functions as a cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Functions as outward-rectifying K(+) channel, but is also permeable to Ca(2+), and to a much lesser degree also to Na(+) (By similarity). May contribute to the release of Ca(2+) stores from the endoplasmic reticulum [...] (1033 aa) |
| | DGKG | Diacylglycerol kinase. (799 aa) |
| | MICU2 | Mitochondrial calcium uptake 2. (435 aa) |
| | EFCAB10 | EF-hand calcium binding domain 10. (132 aa) |
| | CBLB | Cbl proto-oncogene B. (983 aa) |
| | TPPP | Tubulin polymerization-promoting protein; Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (By similarity). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath (By similarity). Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes (By similarity). Shows magnesium [...] (325 aa) |
| | FKBP14 | Peptidylprolyl isomerase. (265 aa) |
| | DGKA | Diacylglycerol kinase alpha; Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity. (734 aa) |
| | RASEF | RAS and EF-hand domain containing. (740 aa) |
| | CBL | Cbl proto-oncogene. (932 aa) |
| | KCNIP1 | Potassium voltage-gated channel interacting protein 1. (220 aa) |
| | PPEF1 | Serine/threonine-protein phosphatase with EF-hands. (658 aa) |
| | ENSBTAP00000060233 | Protein S100; Belongs to the S-100 family. (105 aa) |
| | CALM2 | Uncharacterized protein; Belongs to the calmodulin family. (156 aa) |
| | CAPN2 | Calpain-2 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs. (703 aa) |
| | LOC530689 | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (455 aa) |
| | PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1198 aa) |
| | NECAB2 | Oxidative stress induced growth inhibitor 1. (653 aa) |
| | SPARCL1 | SPARC like 1. (658 aa) |
| | RAB44 | RAB44, member RAS oncogene family. (965 aa) |
| | RYR1 | Ryanodine receptor 1. (5026 aa) |
| | S100A13 | Protein S100-A13; Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity). (98 aa) |
| | PPP3R1 | Calcineurin subunit B type 1; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. (170 aa) |
| | CABP2 | Calcium-binding protein 2; Required for sound encoding at inner hair cells (IHCs) synapses, likely via inhibition of the inactivation of voltage-gated calcium channel of type 1.3 (Cav1.3) in the IHCs. Required for the normal transfer of light signals through the retina. (168 aa) |
| | TBC1D9B | TBC1 domain family member 9B. (1255 aa) |
| | TBC1D9 | TBC1 domain family member 9. (1267 aa) |
| | ITSN2 | Intersectin 2. (1024 aa) |
| | ITSN1 | Intersectin 1. (1716 aa) |
| | RASGRP1 | RAS guanyl releasing protein 1. (797 aa) |
| | MBD4 | EF-hand calcium binding domain 12. (557 aa) |
| | S100A14 | Protein S100-A14; Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium (By similarity). (104 aa) |
| | EHD2 | EH-domain containing 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (543 aa) |
| | RHBDL3 | Rhomboid-related protein 3; May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 family. (402 aa) |
| | AIF1 | Allograft inflammatory factor 1; May play a role in macrophage activation and function. (147 aa) |
| | S100Z | Protein S100; Belongs to the S-100 family. (99 aa) |
| | LETM1 | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion (By similarity). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (By similarity); Belongs to the LETM1 family. (786 aa) |
| | SCGN | Secretagogin. (276 aa) |
| | TPPP3 | Tubulin polymerization-promoting protein family member 3; Regulator of microtubule dynamic that has microtubule bundling activity (By similarity). Required for embryo implantation; possibly by regulating beta-catenin (By similarity). Also required for decidualization via regulation of beta-catenin (By similarity). Belongs to the TPPP family. (170 aa) |
| | S100A4 | Protein S100-A4. (101 aa) |
| | PVALB | Parvalbumin alpha; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity). (110 aa) |
| | GCA | Grancalcin. (201 aa) |
| | CABP7 | Calcium binding protein 7. (215 aa) |
| | EFHC1 | EF-hand domain containing 1. (640 aa) |
| | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity). (1291 aa) |
| | NUCB2 | Nucleobindin 2. (429 aa) |
| | RHBDL1 | Rhomboid-related protein 1; May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 family. (373 aa) |
| | FSTL4 | Follistatin like 4. (843 aa) |
| | S100G | Protein S100-G; Belongs to the S-100 family. (79 aa) |
| | DUOX1 | Dual oxidase 1. (1553 aa) |
| | DUOX2 | Dual oxidase 2. (1545 aa) |
| | CIB3 | Calcium and integrin binding family member 3. (187 aa) |
| | CETN4 | Centrin 4. (166 aa) |
| | CABP5 | Calcium-binding protein 5; Inhibits calcium-dependent inactivation of L-type calcium channel and shifts voltage dependence of activation to more depolarized membrane potentials (By similarity). Involved in the transmission of light signals (By similarity). May positively regulate neurotransmitter vesicle endocytosis and exocytosis in a salt-dependent manner (By similarity). May play a role in the extension and network organization of neurites (By similarity). (173 aa) |
| | STXBP4 | Uncharacterized protein. (560 aa) |
| | MYL12A | Myosin regulatory light polypeptide 9; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. (172 aa) |
| | CALB1 | Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. (261 aa) |
| | CAPN14 | Calpain 14; Belongs to the peptidase C2 family. (685 aa) |
| | TCHHL1 | Trichohyalin-like protein 1; Belongs to the S-100 family. (872 aa) |
| | RCN2 | Reticulocalbin 2, EF-hand calcium binding domain. (317 aa) |
| | SDF4 | 45 kDa calcium-binding protein; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. (355 aa) |
| | PPEF2 | Serine/threonine-protein phosphatase with EF-hands. (753 aa) |
| | RYR2 | Ryanodine receptor 2. (4904 aa) |
| | S100A10 | Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. (97 aa) |
| | EFHD1 | EF-hand domain-containing protein D1; Acts as a calcium sensor for mitochondrial flash (mitoflash) activation, an event characterized by stochastic bursts of superoxide production (By similarity). May play a role in neuronal differentiation (By similarity). (236 aa) |
| | CALM3 | Uncharacterized protein; Belongs to the calmodulin family. (149 aa) |
| | CETN3 | Centrin 3. (167 aa) |
| | S100A16 | Protein S100-A16; Calcium-binding protein. Binds one calcium ion per monomer (By similarity). Can promote differentiation of adipocytes (in vitro) (By similarity). Overexpression in preadipocytes increases their proliferation, enhances adipogenesis and reduces insulin-stimulated glucose uptake (By similarity); Belongs to the S-100 family. (103 aa) |
| | CALML5 | Calmodulin like 5. (148 aa) |
| | SPATA21 | Spermatogenesis associated 21. (670 aa) |
| | PLCZ1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is t [...] (634 aa) |
| | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction. (1194 aa) |
| | SNTN | Sentan; May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet microtubules. (147 aa) |
| | CHP2 | Calcineurin like EF-hand protein 2. (258 aa) |
| | REPS1 | RALBP1 associated Eps domain containing 1. (795 aa) |
| | REPS2 | RALBP1 associated Eps domain containing 2. (461 aa) |
| | NKD1 | NKD inhibitor of WNT signaling pathway 1. (471 aa) |
| | FKBP10 | Peptidyl-prolyl cis-trans isomerase FKBP10; PPIases accelerate the folding of proteins during protein synthesis. (583 aa) |
| | MYL6 | Myosin light polypeptide 6; Regulatory light chain of myosin. Does not bind calcium. (151 aa) |
| | MINDY3 | Ubiquitin carboxyl-terminal hydrolase MINDY-3; Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins; Belongs to the MINDY deubiquitinase family. FAM188 subfamily. (445 aa) |
| | PEF1 | Penta-EF-hand domain containing 1. (287 aa) |
| | SYNRG | Synergin gamma. (1384 aa) |
| | PLCL2 | Phosphoinositide phospholipase C. (1118 aa) |
| | PPP2R3C | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma; May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B- cells. (453 aa) |
| | UTRN | Utrophin. (3432 aa) |
| | C3H1orf87 | Chromosome 3 C1orf87 homolog. (546 aa) |
| | NOX5 | NADPH oxidase 5. (803 aa) |
| | EFCAB9 | EF-hand calcium binding domain 9. (218 aa) |
| | CAPN1 | Calpain-1 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. (717 aa) |
| | CAPN8 | Calpain 8; Belongs to the peptidase C2 family. (706 aa) |
| | NCS1 | Neuronal calcium sensor 1; Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage- gated calcium channel (By similarity); Belongs to the recoverin family. (190 aa) |
| | HPCA | Neuron-specific calcium-binding protein hippocalcin; Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels. May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases. (193 aa) |
| | S100A7 | Protein S100-A7. (101 aa) |
| | G5E5A3_BOVIN | Uncharacterized protein. (275 aa) |
| | CETN2 | Centrin-2; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110 (By similarity). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortio [...] (172 aa) |
| | LCP1 | Lymphocyte cytosolic protein 1. (631 aa) |
| | EFCAB3 | EF-hand calcium-binding domain-containing protein 3. (438 aa) |
| | EHD4 | EH domain containing 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (540 aa) |
| | CAPS | Calcyphosin; Calcium-binding protein. May play a role in cellular signaling events (Potential). (189 aa) |
| | MICU1 | Calcium uptake protein 1, mitochondrial; Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. [...] (478 aa) |
| | P4HTM | Prolyl 4-hydroxylase, transmembrane. (494 aa) |
| | CCAR2 | Cell cycle and apoptosis regulator 2. (916 aa) |
| | S100A1 | Protein S100-A1; Probably acts as a Ca(2+) signal transducer. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change. This conformational change allows interaction of S1001A with specific target proteins, such as TPR- containing proteins, and the modulation of their activity. Belongs to the S-100 family. (94 aa) |
| | CABP4 | Calcium-binding protein 4; May play a role in normal synaptic function, probably through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1F, shifting the activation range to more hyperpolarized voltages (By similarity). (279 aa) |
| | RHOT2 | Mitochondrial Rho GTPase 2; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity). (618 aa) |
| | WDR66 | WD repeat domain 66. (1191 aa) |
| | NECAB3 | N-terminal EF-hand calcium-binding protein 3; Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid-beta (By similarity). May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3 (By similarity). (395 aa) |
| | LOC524650 | Uncharacterized protein. (146 aa) |
| | SLC25A24 | Calcium-binding mitochondrial carrier protein SCaMC-1; Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria (By similarity). (477 aa) |
| | NUCB1 | Nucleobindin-1; Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis. Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity); Belongs to the nucleobindin family. (457 aa) |
| | MYL7 | Myosin light chain 7. (175 aa) |
| | SWAP70 | Switch-associated protein 70; Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity). (585 aa) |
| | FKBP7 | Peptidylprolyl isomerase. (218 aa) |
| | CALB2 | Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons. (271 aa) |
| | RASGRP2 | RAS guanyl-releasing protein 2; Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. (610 aa) |
| | LPCAT1 | Lysophosphatidylcholine acyltransferase 1. (533 aa) |
| | TPPP2 | Tubulin polymerization-promoting protein family member 2; Probable regulator of microtubule dynamics required for sperm motility (By similarity). In contrast to other members of the family, has no microtubule bundling activity (By similarity). Belongs to the TPPP family. (171 aa) |
| | EFCAB14 | EF-hand calcium binding domain 14. (494 aa) |
| | PLCL1 | Phosphoinositide phospholipase C. (1096 aa) |
| | RAB11FIP3 | RAB11 family interacting protein 3. (741 aa) |
| | SPTAN1 | Spectrin alpha, non-erythrocytic 1. (2489 aa) |
| | SLC25A13 | Solute carrier family 25 member 13; Belongs to the mitochondrial carrier (TC 2.A.29) family. (679 aa) |
| | MYL10 | Myosin light chain 10. (283 aa) |
| | LOC615258 | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (471 aa) |
| | CGREF1 | Uncharacterized protein. (492 aa) |
| | LOC112445860 | Protein S100; Belongs to the S-100 family. (101 aa) |
| | DTNB | Dystrobrevin beta. (769 aa) |
| | PLCD1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development. (781 aa) |
| | SLC25A25 | Calcium-binding mitochondrial carrier protein SCaMC-2; Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria (By similarity). (513 aa) |
| | ENSBTAP00000057136 | S_100 domain-containing protein. (636 aa) |
| | GUCA1A | Guanylyl cyclase-activating protein 1; Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure. May be involved in cone photoreceptor light response and recovery of response in bright light (By similarity). (205 aa) |
| | DRP2 | Dystrophin related protein 2. (997 aa) |
| | SMOC2 | SPARC related modular calcium binding 2. (445 aa) |
| | PLCH1 | Phosphoinositide phospholipase C. (1672 aa) |
| | RCN1 | Reticulocalbin 1. (331 aa) |
| | TNNC1 | Troponin C, slow skeletal and cardiac muscles; Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. (161 aa) |
| | FSTL5 | Uncharacterized protein. (847 aa) |
| | DYTN | Dystrotelin. (624 aa) |
| | TNNC2 | Troponin C2, fast skeletal type. (162 aa) |
| | LOC112444303 | Uncharacterized protein; Belongs to the parvalbumin family. (125 aa) |
| | CRACR2A | Calcium release activated channel regulator 2A. (723 aa) |
| | EFCAB6 | EF-hand calcium binding domain 6. (418 aa) |
| | CALN1 | Calneuron 1. (261 aa) |
| | ACTN3 | Alpha-actinin-3; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity); Belongs to the alpha-actinin family. (901 aa) |
| | SPOCK2 | SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2. (424 aa) |
| | RCN3 | Reticulocalbin-3; Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (By similarity). Required for the proper biosynthesis and transport of pulmonary surfactant- associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3 (By similarity). By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (By similarity). Has an anti-fibrotic activity [...] (328 aa) |
| | PLS3 | Plastin-3; Actin-bundling protein. (639 aa) |
| | MACF1 | Microtubule actin crosslinking factor 1. (7311 aa) |
| | FKBP9 | Peptidyl-prolyl cis-trans isomerase FKBP9; PPIases accelerate the folding of proteins during protein synthesis. (574 aa) |
| | S100A12 | Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF- kappa-B signaling pathways leadi [...] (95 aa) |
| | EFCAB2 | EF-hand calcium binding domain 2. (164 aa) |
| | PLCD3 | Phosphoinositide phospholipase C. (815 aa) |
| | ZZEF1 | Zinc finger ZZ-type and EF-hand domain containing 1. (2962 aa) |
| | DST | Dystonin. (3697 aa) |
| | LOC112442678 | EF-hand domain-containing protein. (353 aa) |
| | RCVRN | Recoverin; Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells. Modulates light sensitivity of cone photoreceptor in dark and dim conditions (By similarity). In response to high Ca(2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin. Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells (By similarity). Improves rod photoreceptor sensitivi [...] (202 aa) |
| | GUCA1B | Guanylyl cyclase-activating protein 2; Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure. May be involved in cone photoreceptor response and recovery of response in bright light (By similarity). (204 aa) |
| | CALML4 | Calmodulin-like protein 4; Belongs to the calmodulin family. (196 aa) |
| | TBC1D8 | TBC1 domain family member 8. (1142 aa) |
| | MYL12B | Myosin regulatory light chain 12B; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion. (171 aa) |
| | CHP1 | Calcineurin B homologous protein 1; Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane- type Na(+)/H(+) ex [...] (195 aa) |
| | MICU3 | Mitochondrial calcium uptake family member 3. (533 aa) |
| | SMOC1 | SPARC related modular calcium binding 1. (445 aa) |
| | CRACR2B | Calcium release activated channel regulator 2B. (449 aa) |
| | PLCD4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration [...] (791 aa) |
| | MYL6B | Myosin, light chain 6B, alkali, smooth muscle and non-muscle. (211 aa) |
| | EHD3 | EH domain containing 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (535 aa) |
| | CAPN12 | Calpain 12; Belongs to the peptidase C2 family. (721 aa) |
| | EFHD2 | EF-hand domain-containing protein D2; May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance. (242 aa) |
| | TBC1D8B | TBC1 domain family member 8B. (1121 aa) |
| | LOC786350 | Protein S100; Belongs to the S-100 family. (101 aa) |
| | CAPS2 | Calcyphosine 2. (288 aa) |
| | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa) |
| | NINL | Uncharacterized protein. (956 aa) |
| | F1N7P3_BOVIN | Uncharacterized protein. (495 aa) |
| | MYL1 | Myosin light chain 1/3, skeletal muscle isoform; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. (192 aa) |
| | CALM | Calmodulin; Belongs to the calmodulin family. (149 aa) |
| | MYL4 | Myosin, light chain 4, alkali; atrial, embryonic. (193 aa) |
| | CCAR1 | SAP domain-containing protein. (1138 aa) |
| | SRI | Sorcin. (198 aa) |
| | EPS15 | Epidermal growth factor receptor pathway substrate 15. (910 aa) |
| | CETN1 | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function (By similarity). Plays a role in sperm cilia formation (By similarity); Belongs to the centrin family. (172 aa) |
| | PLS1 | Plastin-1; Actin-bundling protein in the absence of calcium. (630 aa) |
| | EFHB | EF-hand domain family member B. (877 aa) |
| | DGKB | Diacylglycerol kinase. (803 aa) |
| | SPTA1 | Spectrin alpha, erythrocytic 1. (2411 aa) |
