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BMP10 BMP10 GDF10 GDF10 LOC100336971 LOC100336971 BMP4 BMP4 GDF5 GDF5 GDF2 GDF2 BMP2 BMP2 INHBE INHBE GDF11 GDF11 GDF9 GDF9 INHA INHA MSTN MSTN TGFB3 TGFB3 BMP5 BMP5 NODAL NODAL GDF15 GDF15 BMP3 BMP3 BMP8A BMP8A INHBC INHBC BMP6 BMP6 GDF1 GDF1 GDF3 GDF3 GDF6 GDF6 LEFTY2 LEFTY2 F1MKJ7_BOVIN F1MKJ7_BOVIN GDF7 GDF7 BMP7 BMP7 BMP8B BMP8B BMP15 BMP15 INHBA INHBA INHBB INHBB TGFB2 TGFB2 TGFB1 TGFB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMP10Bone morphogenetic protein 10. (424 aa)
GDF10Growth/differentiation factor 10; Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis. (478 aa)
LOC100336971Left-right determination factor. (367 aa)
BMP4Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
GDF5Growth differentiation factor 5. (499 aa)
GDF2Growth differentiation factor 2. (431 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
INHBEInhibin subunit beta E. (348 aa)
GDF11Growth differentiation factor 11. (406 aa)
GDF9Growth/differentiation factor 9; Required for ovarian folliculogenesis. (453 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins; Belongs to the TGF-beta family. (360 aa)
MSTNGrowth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth. (375 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
NODALNodal growth differentiation factor. (346 aa)
GDF15Growth differentiation factor 15. (308 aa)
BMP3Bone morphogenetic protein 3; Induces cartilage and bone formation. (475 aa)
BMP8ATGF_BETA_2 domain-containing protein. (405 aa)
INHBCInhibin subunit beta C. (352 aa)
BMP6Bone morphogenetic protein 6. (496 aa)
GDF1Growth differentiation factor 1. (369 aa)
GDF3TGF_BETA_2 domain-containing protein. (364 aa)
GDF6Growth/differentiation factor 6; Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal- ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-speci [...] (470 aa)
LEFTY2Left-right determination factor. (367 aa)
F1MKJ7_BOVINTGF_BETA_2 domain-containing protein. (364 aa)
GDF7Growth differentiation factor 7. (450 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
BMP8BTGF_BETA_2 domain-containing protein. (405 aa)
BMP15Bone morphogenetic protein 15; May be involved in follicular development. Seems to be an oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity). (394 aa)
INHBAInhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (425 aa)
INHBBInhibin beta B chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (408 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (442 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (499 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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