STRINGSTRING
HAPLN3 HAPLN3 CHODL CHODL LYVE1 LYVE1 MBL1 MBL1 NCAN NCAN HAPLN4 HAPLN4 CD69 CD69 CGN1 CGN1 OLR1 OLR1 CLEC4F CLEC4F CD207 CD207 CLEC18C CLEC18C LOC513869 LOC513869 CLEC11A CLEC11A STAB2 STAB2 CLEC14A CLEC14A SFTPD SFTPD LOC617565 LOC617565 LOC784451 LOC784451 MBL2 MBL2 REG3G REG3G SELE SELE CD209 CD209 KLRA1 KLRA1 CLEC9A CLEC9A CD72 CD72 ASGR1 ASGR1 CLEC4E CLEC4E CLEC4G CLEC4G KLRG1 KLRG1 COL4A4 COL4A4 CL46 CL46 CLEC1A CLEC1A STAB1 STAB1 HAPLN2 HAPLN2 ACAN ACAN COLEC11 COLEC11 KLRG2 KLRG2 LAYN LAYN CLEC19A CLEC19A CLEC3B CLEC3B LOC112444733 LOC112444733 FREM1 FREM1 CLEC5A CLEC5A SELP SELP COL4A3 COL4A3 LOC101907929 LOC101907929 CLEC12B CLEC12B KLRJ1 KLRJ1 LOC100847738 LOC100847738 CLEC6A CLEC6A COL18A1 COL18A1 ASGR2 ASGR2 COL4A1 COL4A1 KLRD1 KLRD1 ATRN ATRN KLRF1 KLRF1 LOC100848575 LOC100848575 FCER2 FCER2 REG4 REG4 SELL SELL COLEC12 COLEC12 SUSD5 SUSD5 CLEC2L CLEC2L CD44 CD44 CD302 CD302 CLEC1B CLEC1B CLEC10A CLEC10A MRC1 MRC1 CD93 CD93 CLECL1 CLECL1 SUMF1 SUMF1 CLEC4D CLEC4D NKG2C NKG2C PKD1L2 PKD1L2 LY75 LY75 CD248 CD248 LOC100297676 LOC100297676 CLEC3A CLEC3A CLEC2A CLEC2A KLRF2 KLRF2 CLEC12A CLEC12A NKG2A NKG2A LOC509972 LOC509972 COL4A2 COL4A2 PKD1L3 PKD1L3 CLEC17A CLEC17A PRG3 PRG3 COL15A1 COL15A1 PLA2R1 PLA2R1 CLEC4A CLEC4A KLRC1 KLRC1 LOC618565 LOC618565 SUMF2 SUMF2 BCAN BCAN CLEC7A CLEC7A ENSBTAP00000066052 ENSBTAP00000066052 LOC520402 LOC520402 LOC781990 LOC781990 TNFAIP6 TNFAIP6 ENSBTAP00000066695 ENSBTAP00000066695 PRG3-2 PRG3-2 COL4A5 COL4A5 VCAN VCAN KLRB1 KLRB1 ATRNL1 ATRNL1 CLEC2B CLEC2B MRC2 MRC2 ENSBTAP00000069790 ENSBTAP00000069790 LOC100296778 LOC100296778 PTPRQ PTPRQ LOC100336869 LOC100336869 ENSBTAP00000070779 ENSBTAP00000070779 KLRK1 KLRK1 SFTPA1 SFTPA1 HAPLN1 HAPLN1 COLEC10 COLEC10 COL4A6 COL4A6 DGCR2 DGCR2 REG3A REG3A LOC101905403 LOC101905403 LOC100140174 LOC100140174 LOC100294723 LOC100294723 ENSBTAP00000074264 ENSBTAP00000074264
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HAPLN3Hyaluronan and proteoglycan link protein 3. (360 aa)
CHODLCHODL protein. (273 aa)
LYVE1Lymphatic vessel endothelial hyaluronic acid receptor 1; Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. (322 aa)
MBL1Liver mannan-binding lectin. (248 aa)
NCANNeurocan. (1347 aa)
HAPLN4Hyaluronan and proteoglycan link protein 4. (402 aa)
CD69Early activation molecule CD69. (199 aa)
CGN1Conglutinin; Calcium-dependent lectin-like protein which binds to a yeast cell wall extract and immune complexes through the complement component (C3bi). It is capable of binding non-reducing terminal N- acetylglucosamine, mannose, and fucose residues. (371 aa)
OLR1Oxidized low-density lipoprotein receptor 1, soluble form A; Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses includ [...] (273 aa)
CLEC4FC-type lectin domain family 4 member F. (607 aa)
CD207CD207 molecule. (329 aa)
CLEC18CMRCL protein. (624 aa)
LOC513869C-type lectin domain-containing protein. (236 aa)
CLEC11AC-type lectin domain containing 11A. (324 aa)
STAB2Stabilin 2. (2549 aa)
CLEC14AC-type lectin domain family 14, member A. (490 aa)
SFTPDPulmonary surfactant-associated protein D; Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha- glucosyl moieties; Belongs to the SFTPD family. (369 aa)
LOC617565C-type lectin domain-containing protein. (205 aa)
LOC784451C-type lectin domain-containing protein. (230 aa)
MBL2Mannose-binding protein C; Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity). (249 aa)
REG3GRegenerating islet-derived 3 gamma. (172 aa)
SELEE-selectin; Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis. (485 aa)
CD209DC-SIGN-like protein. (259 aa)
KLRA1NK receptor Ly49. (277 aa)
CLEC9AC-type lectin domain containing 9A. (241 aa)
CD72CD72 molecule. (360 aa)
ASGR1Asialoglycoprotein receptor 1. (286 aa)
CLEC4EC-type lectin domain family 4 member E. (211 aa)
CLEC4GC-type lectin domain family 4 member G. (290 aa)
KLRG1Killer cell lectin like receptor G1. (186 aa)
COL4A4Collagen alpha-4(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. (450 aa)
CL46Collectin-46; Belongs to the SFTPD family. (371 aa)
CLEC1AC-type lectin domain family 1 member A. (278 aa)
STAB1Stabilin 1. (2568 aa)
HAPLN2Hyaluronan and proteoglycan link protein 2. (340 aa)
ACANAggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. (2366 aa)
COLEC11Collectin-11; Lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope. Primarily recognizes the terminal disaccharide of the glycan. Also recognizes a subset of fucosylated glycans and lipopolysaccharides. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1. Also plays a role in apoptosis [...] (267 aa)
KLRG2Killer cell lectin like receptor G2. (422 aa)
LAYNLayilin. (373 aa)
CLEC19AC-type lectin domain containing 19A. (136 aa)
CLEC3BTetranectin; Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis (By similarity). (282 aa)
LOC112444733C-type lectin domain-containing protein. (368 aa)
FREM1FRAS1 related extracellular matrix 1. (2180 aa)
CLEC5AC-type lectin domain containing 5A. (195 aa)
SELPP-selectin; Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG (By similarity). Belongs to the selectin/LECAM family. (646 aa)
COL4A3Collagen alpha-3(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. (1670 aa)
LOC101907929C-type lectin domain-containing protein. (363 aa)
CLEC12BC-type lectin domain family 12 member B; Cell surface receptor that protects target cells against natural killer cell-mediated lysis. Modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases (By similarity). (276 aa)
KLRJ1C-type lectin domain-containing protein. (275 aa)
LOC100847738KLRC1 protein. (245 aa)
CLEC6AC-type lectin domain family 6 member A; Binds high-mannose carbohydrates in a Ca(2+)-dependent manner (By similarity). Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G a [...] (206 aa)
COL18A1Collagen type XVIII alpha 1 chain. (1514 aa)
ASGR2Asialoglycoprotein receptor 2. (281 aa)
COL4A1Collagen alpha-1(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. (1669 aa)
KLRD1Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. (190 aa)
ATRNAttractin. (1415 aa)
KLRF1Killer cell lectin like receptor F1. (233 aa)
LOC100848575C-type lectin domain-containing protein. (264 aa)
FCER2Fc fragment of IgE receptor II. (302 aa)
REG4Regenerating islet-derived family, member 4. (158 aa)
SELLL-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. (399 aa)
COLEC12Collectin-12; Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-oros [...] (742 aa)
SUSD5Sushi domain containing 5. (624 aa)
CLEC2LC-type lectin domain family 2 member L. (219 aa)
CD44CD44 antigen. (703 aa)
CD302CD302 antigen; Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration. (232 aa)
CLEC1BC-type lectin domain family 1 member B. (230 aa)
CLEC10AC-type lectin domain containing 10A. (308 aa)
MRC1Mannose receptor C-type 1. (1441 aa)
CD93CD93 molecule. (648 aa)
CLECL1LOC618591 protein. (215 aa)
SUMF1Formylglycine-generating enzyme; Oxidase that catalyzes the conversion of cysteine to 3- oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3- oxoalanine as a catalytic nucleophile. Known substrates include GALNS, ARSA, STS and ARSE. (374 aa)
CLEC4DC-type lectin domain family 4 member D. (213 aa)
NKG2CC-type lectin domain-containing protein. (197 aa)
PKD1L2Uncharacterized protein. (2428 aa)
LY75Uncharacterized protein. (1723 aa)
CD248CD248 molecule. (776 aa)
LOC100297676C-type lectin domain-containing protein. (212 aa)
CLEC3AC-type lectin domain family 3 member A; Promotes cell adhesion to laminin and fibronectin. (197 aa)
CLEC2AC-type lectin domain family 2 member A. (119 aa)
KLRF2Killer cell lectin like receptor F2. (205 aa)
CLEC12AC-type lectin domain family 12 member A. (286 aa)
NKG2ANKG2A. (235 aa)
LOC509972C-type lectin domain-containing protein. (203 aa)
COL4A2Collagen alpha-2(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Potently inhibits angiogenesis and tumor growth (By similarity). (1551 aa)
PKD1L3Polycystin 1 like 3, transient receptor potential channel interacting. (1697 aa)
CLEC17AUncharacterized protein. (273 aa)
PRG3PRG3 protein. (218 aa)
COL15A1Collagen type XV alpha 1 chain. (1398 aa)
PLA2R1Soluble secretory phospholipase A2 receptor; Receptor for secretory phospholipase A2 (sPLA2). Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marro [...] (1633 aa)
CLEC4AC-type lectin domain family 4 member A. (237 aa)
KLRC1Killer cell lectin-like receptor subfamily C1 member 4. (236 aa)
LOC618565C-type lectin domain-containing protein. (178 aa)
SUMF2Inactive C-alpha-formylglycine-generating enzyme 2; Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. Belongs to the sulfatase-modifying factor family. (315 aa)
BCANBrevican core protein; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. (912 aa)
CLEC7AC-type lectin domain family 7 member A; Lectin that functions as pattern receptor specific for beta- 1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Induces phosphorylation of SCIMP after binding beta-glucans (By similarity). Necessary for the TLR2- mediated inflammatory response and for TLR2-mediated activation of NF- kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does [...] (247 aa)
ENSBTAP00000066052C-type lectin domain-containing protein. (236 aa)
LOC520402C-type lectin domain-containing protein. (218 aa)
LOC781990MGC140461 protein. (218 aa)
TNFAIP6Tumor necrosis factor, alpha-induced protein 6. (280 aa)
ENSBTAP00000066695C-type lectin domain-containing protein. (122 aa)
PRG3-2PRG3 protein. (218 aa)
COL4A5Collagen type IV alpha 5 chain. (1538 aa)
VCANVersican core protein; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. (3381 aa)
KLRB1Killer cell lectin like receptor B1. (226 aa)
ATRNL1Attractin like 1. (1381 aa)
CLEC2BC-type lectin domain-containing protein. (181 aa)
MRC2Mannose receptor C type 2. (1488 aa)
ENSBTAP00000069790C-type lectin domain-containing protein. (170 aa)
LOC100296778C-type lectin domain-containing protein. (152 aa)
PTPRQProtein tyrosine phosphatase receptor type Q. (3386 aa)
LOC100336869Killer cell lectin-like receptor subfamily C1 member 2. (243 aa)
ENSBTAP00000070779C-type lectin domain-containing protein. (90 aa)
KLRK1C-type lectin domain-containing protein. (202 aa)
SFTPA1Pulmonary surfactant-associated protein A; In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air- liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages; Belongs to the SFTPA family. (309 aa)
HAPLN1Hyaluronan and proteoglycan link protein 1; Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix; Belongs to the HAPLN family. (354 aa)
COLEC10C-type lectin domain-containing protein. (277 aa)
COL4A6Collagen type IV alpha 6 chain. (1706 aa)
DGCR2C-type lectin domain-containing protein. (547 aa)
REG3ALithostathine A chain; Might act as an inhibitor of spontaneous calcium carbonate precipitation. (175 aa)
LOC101905403C-type lectin domain-containing protein. (217 aa)
LOC100140174C-type lectin domain-containing protein. (241 aa)
LOC100294723C-type lectin domain-containing protein. (257 aa)
ENSBTAP00000074264C-type lectin domain-containing protein. (213 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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