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GZMK GZMK OVCH1 OVCH1 F2 F2 LOC786948 LOC786948 F7 F7 CFB CFB PRSS42 PRSS42 CTRB1 CTRB1 CELA1 CELA1 LOC540321 LOC540321 TMPRSS2 TMPRSS2 KLK13 KLK13 LOC529047 LOC529047 KLKB1 KLKB1 GZMB GZMB ACR ACR KLK14 KLK14 LOC786126 LOC786126 LOC508858 LOC508858 CELA3B CELA3B TMPRSS7 TMPRSS7 KLK7 KLK7 KLK8 KLK8 PRSS23 PRSS23 F10 F10 LOC112442302 LOC112442302 HGFAC HGFAC KLK1 KLK1 KLK15 KLK15 F12 F12 HABP2 HABP2 ST14 ST14 TMPRSS11A TMPRSS11A KLK4 KLK4 PRSS27 PRSS27 PRSS12 PRSS12 PRSS33 PRSS33 TMPRSS3 TMPRSS3 TMPRSS4 TMPRSS4 PRSS2 PRSS2 GZMA GZMA KLK10 KLK10 PRSS38 PRSS38 LOC518437 LOC518437 PRSS8 PRSS8 LOC615237 LOC615237 PRSS57 PRSS57 gzmA gzmA LOC780846 LOC780846 PRSS53 PRSS53 C2 C2 TMPRSS6 TMPRSS6 PRSS55 PRSS55 PRSS50 PRSS50 F9 F9 LOC618826 LOC618826 LOC100140490 LOC100140490 KLK9 KLK9 PRSS46P PRSS46P LOC505658 LOC505658 TMPRSS11E TMPRSS11E LOC112447768 LOC112447768 PRSS36 PRSS36 ELANE ELANE PRTN3 PRTN3 LOC789799 LOC789799 LOC617663 LOC617663 TMPRSS13 TMPRSS13 PRSS21 PRSS21 OVCH2 OVCH2 CFD CFD PRSS22 PRSS22 ENSBTAP00000058788 ENSBTAP00000058788 ENSBTAP00000059592 ENSBTAP00000059592 F11 F11 CELA2A CELA2A TMPRSS12 TMPRSS12 TPSB2 TPSB2 LOC617313 LOC617313 ENSBTAP00000064959 ENSBTAP00000064959 LOC112443487 LOC112443487 KLK5 KLK5 PRSS35 PRSS35 ENSBTAP00000069139 ENSBTAP00000069139 ENSBTAP00000069583 ENSBTAP00000069583 CTRC CTRC PRSS56 PRSS56 CFI CFI KLK6 KLK6 TMPRSS11BNL TMPRSS11BNL PLAU PLAU GZMB-2 GZMB-2 LOC505326 LOC505326 KLK12 KLK12 KLK11 KLK11 GZMM GZMM TMPRSS11D TMPRSS11D PLG PLG PLAT PLAT TMPRSS9 TMPRSS9 TMPRSS15 TMPRSS15 LOC780933 LOC780933 HPN HPN PRSS45 PRSS45 TMPRSS11F TMPRSS11F PRSS48 PRSS48
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GZMKGranzyme K; Belongs to the peptidase S1 family. (264 aa)
OVCH1Ovochymase 1; Belongs to the peptidase S1 family. (1073 aa)
F2Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity); Belongs to the peptidase S1 family. (625 aa)
LOC786948TPSB1 protein; Belongs to the peptidase S1 family. (271 aa)
F7Coagulation factor VII; Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium; Belongs to the peptidase S1 family. (447 aa)
CFBComplement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. (761 aa)
PRSS42Serine protease 42, pseudogene; Belongs to the peptidase S1 family. (337 aa)
CTRB1Chymotrypsin B chain A; Belongs to the peptidase S1 family. (263 aa)
CELA1Chymotrypsin-like elastase family member 1; Acts upon elastin. (266 aa)
LOC540321Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (247 aa)
TMPRSS2Transmembrane protease, serine 2; Belongs to the peptidase S1 family. (490 aa)
KLK13Kallikrein related peptidase 13; Belongs to the peptidase S1 family. (278 aa)
LOC529047Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (360 aa)
KLKB1Plasma kallikrein heavy chain; The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin (By similarity). (636 aa)
GZMBGranzyme B; Belongs to the peptidase S1 family. (246 aa)
ACRAcrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome. (414 aa)
KLK14Kallikrein related peptidase 14; Belongs to the peptidase S1 family. (251 aa)
LOC786126Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (251 aa)
LOC508858Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (255 aa)
CELA3BProproteinase E; May protect procarboxypeptidase A against denaturation in the acidic environment of the ruminant duodenum; Belongs to the peptidase S1 family. (270 aa)
TMPRSS7Transmembrane serine protease 7. (717 aa)
KLK7Kallikrein-related peptidase 7; Belongs to the peptidase S1 family. (251 aa)
KLK8Kallikrein related peptidase 8; Belongs to the peptidase S1 family. (259 aa)
PRSS23Serine protease 23. (375 aa)
F10Activated factor Xa heavy chain; Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting; Belongs to the peptidase S1 family. (608 aa)
LOC112442302Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (212 aa)
HGFACHGF activator. (651 aa)
KLK1Glandular kallikrein; Belongs to the peptidase S1 family. (261 aa)
KLK15Kallikrein related peptidase 15; Belongs to the peptidase S1 family. (257 aa)
F12Coagulation factor XIIa heavy chain; Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (By similarity). (603 aa)
HABP2Hyaluronan-binding protein 2 27 kDa light chain alternate form; Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII (By similarity); Belongs to the peptidase S1 family. (558 aa)
ST14Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site (By similarity). Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing (By similarity); Belongs to the peptidase S1 family. (855 aa)
TMPRSS11ATransmembrane protease serine; Belongs to the peptidase S1 family. (415 aa)
KLK4Kallikrein related peptidase 4; Belongs to the peptidase S1 family. (255 aa)
PRSS27Serine protease 27; Belongs to the peptidase S1 family. (311 aa)
PRSS12Serine protease 12; Belongs to the peptidase S1 family. (871 aa)
PRSS33Serine protease 33; Belongs to the peptidase S1 family. (281 aa)
TMPRSS3Transmembrane serine protease 3; Belongs to the peptidase S1 family. (453 aa)
TMPRSS4Transmembrane serine protease 4; Belongs to the peptidase S1 family. (446 aa)
PRSS2Anionic trypsin; Belongs to the peptidase S1 family. (247 aa)
GZMAGZMA protein; Belongs to the peptidase S1 family. (259 aa)
KLK10Kallikrein-related peptidase 10; Belongs to the peptidase S1 family. (280 aa)
PRSS38Serine protease 38; Belongs to the peptidase S1 family. (329 aa)
LOC518437Transmembrane protease serine; Belongs to the peptidase S1 family. (415 aa)
PRSS8Serine protease 8; Belongs to the peptidase S1 family. (343 aa)
LOC615237Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (233 aa)
PRSS57Serine protease 57; Belongs to the peptidase S1 family. (283 aa)
gzmAGranzyme A; Abundant protease in the cytosolic granules of cytotoxic T- cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA (By similarity); Belongs to the peptidase S1 [...] (258 aa)
LOC780846Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (243 aa)
PRSS53Serine protease 53; Belongs to the peptidase S1 family. (578 aa)
C2Complement C2a fragment; Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase (By similarity). Belongs to the peptidase S1 family. (787 aa)
TMPRSS6Transmembrane serine protease 6; Belongs to the peptidase S1 family. (839 aa)
PRSS55Serine protease 55; Belongs to the peptidase S1 family. (314 aa)
PRSS50Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (418 aa)
F9Coagulation factor IXa heavy chain; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. (447 aa)
LOC618826CTRB1 protein; Belongs to the peptidase S1 family. (263 aa)
LOC100140490Transmembrane protease serine; Belongs to the peptidase S1 family. (413 aa)
KLK9Kallikrein F; Belongs to the peptidase S1 family. (251 aa)
PRSS46PPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (303 aa)
LOC505658Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (251 aa)
TMPRSS11ETransmembrane protease serine; Belongs to the peptidase S1 family. (423 aa)
LOC112447768Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (318 aa)
PRSS36Polyserase-2; Serine protease. Has a preference for substrates with an Arg instead of a Lys residue in position P1. (827 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (286 aa)
PRTN3Proteinase 3; Belongs to the peptidase S1 family. (256 aa)
LOC789799Uncharacterized protein; Belongs to the peptidase S1 family. (280 aa)
LOC617663Uncharacterized protein; Belongs to the peptidase S1 family. (281 aa)
TMPRSS13Transmembrane serine protease 13; Belongs to the peptidase S1 family. (515 aa)
PRSS21Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (271 aa)
OVCH2Ovochymase 2; Belongs to the peptidase S1 family. (553 aa)
CFDComplement factor D; Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway (By similarity). (259 aa)
PRSS22Serine protease 22; Belongs to the peptidase S1 family. (343 aa)
ENSBTAP00000058788Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (312 aa)
ENSBTAP00000059592Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (385 aa)
F11Coagulation factor XIa heavy chain; Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX; Belongs to the peptidase S1 family. Plasma kallikrein subfamily. (640 aa)
CELA2AChymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. (299 aa)
TMPRSS12Transmembrane serine protease 12; Belongs to the peptidase S1 family. (343 aa)
TPSB2Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (298 aa)
LOC617313Granzyme H; Belongs to the peptidase S1 family. (265 aa)
ENSBTAP00000064959Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (319 aa)
LOC112443487Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (388 aa)
KLK5Kallikrein related peptidase 5; Belongs to the peptidase S1 family. (293 aa)
PRSS35Inactive serine protease 35. (412 aa)
ENSBTAP00000069139Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (342 aa)
ENSBTAP00000069583Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (242 aa)
CTRCChymotrypsin-C; Has chymotrypsin-type protease activity and hypocalcemic activity. (310 aa)
PRSS56Serine protease 56; Belongs to the peptidase S1 family. (612 aa)
CFIComplement factor I; Belongs to the peptidase S1 family. (618 aa)
KLK6Kallikrein related peptidase 6; Belongs to the peptidase S1 family. (246 aa)
TMPRSS11BNLTransmembrane protease serine; Belongs to the peptidase S1 family. (416 aa)
PLAUUrokinase-type plasminogen activator short chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin; Belongs to the peptidase S1 family. (440 aa)
GZMB-2Duodenase-1; Protease which has both trypsin-like and chymotrypsin-like activities. Shows a preferential cleavage after Lys, Arg, Tyr, Phe, and Leu residues. (251 aa)
LOC505326Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (263 aa)
KLK12Kallikrein related peptidase 12; Belongs to the peptidase S1 family. (248 aa)
KLK11Kallikrein related peptidase 11; Belongs to the peptidase S1 family. (343 aa)
GZMMGranzyme M; Belongs to the peptidase S1 family. (258 aa)
TMPRSS11DTransmembrane protease serine; Belongs to the peptidase S1 family. (415 aa)
PLGPlasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...] (812 aa)
PLATTissue-type plasminogen activator chain A; Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. (566 aa)
TMPRSS9Transmembrane serine protease 9; Belongs to the peptidase S1 family. (1095 aa)
TMPRSS15Enteropeptidase non-catalytic heavy chain; Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases. (1035 aa)
LOC780933Alpha-trypsin chain 1. (246 aa)
HPNHepsin (Transmembrane protease, serine 1); Belongs to the peptidase S1 family. (417 aa)
PRSS45Serine protease 45. (316 aa)
TMPRSS11FTransmembrane protease serine; Belongs to the peptidase S1 family. (437 aa)
PRSS48Serine protease 48; Belongs to the peptidase S1 family. (320 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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