STRINGSTRING
EFCAB6 EFCAB6 CALM-2 CALM-2 EFCAB1 EFCAB1 CIB2 CIB2 LPCAT2 LPCAT2 KCNIP4 KCNIP4 ACTN1 ACTN1 S100A5 S100A5 S100A11 S100A11 VSNL1 VSNL1 PRKCSH PRKCSH S100A2 S100A2 ACTN4 ACTN4 EPS15L1 EPS15L1 ENSBTAP00000070572 ENSBTAP00000070572 PDCD6 PDCD6 CAPNS1 CAPNS1 SLC25A23 SLC25A23 USP32 USP32 NCALD NCALD EFCAB7 EFCAB7 CALM1 CALM1 CABP1 CABP1 CALU CALU RHOT1 RHOT1 PPP2R3A PPP2R3A ENSBTAP00000068220 ENSBTAP00000068220 EHD1 EHD1 MCFD2 MCFD2 EFCAB8 EFCAB8 SLC25A12 SLC25A12 CAPN3 CAPN3 PPP2R3B PPP2R3B PLCH2 PLCH2 CAPSL CAPSL CIB1 CIB1 TCHH TCHH ENSBTAP00000066314 ENSBTAP00000066314 MYL2 MYL2 HPCAL4 HPCAL4 KCNIP3 KCNIP3 MYLPF MYLPF KCNIP2 KCNIP2 SPARC SPARC GPD2 GPD2 CIB4 CIB4 MYL9 MYL9 RASGRP3 RASGRP3 S100B S100B HPCAL1 HPCAL1 ENSBTAP00000063139 ENSBTAP00000063139 CRNN CRNN DGKG DGKG FKBP14 FKBP14 DGKA DGKA RASEF RASEF KCNIP1 KCNIP1 PPEF1 PPEF1 ENSBTAP00000060233 ENSBTAP00000060233 CALM2 CALM2 CAPN2 CAPN2 NECAB2 NECAB2 SPARCL1 SPARCL1 PPP3R1 PPP3R1 SPTAN1 SPTAN1 MYL10 MYL10 LOC615258 LOC615258 CGREF1 CGREF1 LOC112445860 LOC112445860 PLCD1 PLCD1 ENSBTAP00000057136 ENSBTAP00000057136 GUCA1A GUCA1A SMOC2 SMOC2 PLCH1 PLCH1 RCN1 RCN1 TNNC1 TNNC1 FSTL5 FSTL5 TNNC2 TNNC2 LOC112444303 LOC112444303 CRACR2A CRACR2A CALN1 CALN1 DST DST DGKB DGKB EFHB EFHB PLS1 PLS1 CETN1 CETN1 EPS15 EPS15 SRI SRI CALM CALM F1N7P3_BOVIN F1N7P3_BOVIN NINL NINL CAPS2 CAPS2 LOC786350 LOC786350 CAPN12 CAPN12 EHD3 EHD3 PLCD4 PLCD4 SMOC1 SMOC1 MICU3 MICU3 CHP1 CHP1 DNAH7 DNAH7 MYL12B MYL12B GUCA1B GUCA1B RCVRN RCVRN LOC112442678 LOC112442678 S100A12 S100A12 FKBP9 FKBP9 MACF1 MACF1 PLS3 PLS3 RCN3 RCN3 CABP2 CABP2 ITSN2 ITSN2 ITSN1 ITSN1 RASGRP1 RASGRP1 EHD2 EHD2 S100Z S100Z LETM1 LETM1 SCGN SCGN GNPTAB GNPTAB S100A4 S100A4 PVALB PVALB GCA GCA CABP7 CABP7 PLCG1 PLCG1 NUCB2 NUCB2 FSTL4 FSTL4 S100G S100G DUOX1 DUOX1 DUOX2 DUOX2 CIB3 CIB3 CETN4 CETN4 CABP5 CABP5 MYL12A MYL12A CALB1 CALB1 CAPN14 CAPN14 RCN2 RCN2 SDF4 SDF4 PPEF2 PPEF2 CALM3 CALM3 CETN3 CETN3 S100A16 S100A16 CALML5 CALML5 SPATA21 SPATA21 CHP2 CHP2 REPS1 REPS1 REPS2 REPS2 NKD1 NKD1 FKBP10 FKBP10 PEF1 PEF1 PPP2R3C PPP2R3C NOX5 NOX5 CAPN1 CAPN1 CAPN8 CAPN8 NCS1 NCS1 HPCA HPCA S100A7 S100A7 CETN2 CETN2 LCP1 LCP1 EFCAB3 EFCAB3 EHD4 EHD4 CAPS CAPS MICU1 MICU1 P4HTM P4HTM S100A1 S100A1 CABP4 CABP4 RHOT2 RHOT2 NECAB3 NECAB3 LOC524650 LOC524650 SLC25A24 SLC25A24 NUCB1 NUCB1 MYL7 MYL7 FKBP7 FKBP7 CALB2 CALB2 RASGRP2 RASGRP2
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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co-expression
protein homology
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EFCAB6EF-hand calcium binding domain 6. (418 aa)
CALM-2Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). (149 aa)
EFCAB1EF-hand calcium-binding domain-containing protein 1. (212 aa)
CIB2Calcium and integrin binding family member 2. (187 aa)
LPCAT2Lysophosphatidylcholine acyltransferase 2. (531 aa)
KCNIP4Kv channel-interacting protein 4; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents (By similarity); Belongs to the recoverin family. (250 aa)
ACTN1Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). (914 aa)
S100A5Protein S100; Belongs to the S-100 family. (93 aa)
S100A11Protein S100; Belongs to the S-100 family. (142 aa)
VSNL1Visinin-like protein 1; Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner. (208 aa)
PRKCSHGlucosidase 2 subunit beta; Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (By similarity). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). (593 aa)
S100A2Protein S100-A2; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth (By similarity). (97 aa)
ACTN4Alpha-actinin-4; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions. May also function as a transcriptional coactivator, stimulating transcri [...] (1032 aa)
EPS15L1Epidermal growth factor receptor pathway substrate 15 like 1. (939 aa)
ENSBTAP00000070572Uncharacterized protein. (103 aa)
PDCD6Programmed cell death 6. (191 aa)
CAPNS1Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. (290 aa)
SLC25A23Solute carrier family 25 member 23; Belongs to the mitochondrial carrier (TC 2.A.29) family. (496 aa)
USP32Ubiquitin specific peptidase 32; Belongs to the peptidase C19 family. (1631 aa)
NCALDNeurocalcin-delta; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions. (193 aa)
EFCAB7EF-hand calcium binding domain 7. (629 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (150 aa)
CABP1Calcium-binding protein 1; Modulates calcium-dependent activity of inositol 1,4,5- triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium- dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L- type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function. Suppresses the calcium-dependent inactivation of CACNA1D. Inhibits TRPC5 cha [...] (417 aa)
CALUCalumenin; Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma- carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity). (315 aa)
RHOT1Mitochondrial Rho GTPase 1; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity). (720 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1150 aa)
ENSBTAP00000068220Uncharacterized protein. (610 aa)
EHD1EH domain-containing protein 1; ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth. Plays a role in myoblast fusion. Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing. Plays a role in the formation of the ciliary v [...] (534 aa)
MCFD2Multiple coagulation factor deficiency 2. (335 aa)
EFCAB8EF-hand calcium binding domain 8. (1232 aa)
SLC25A12Solute carrier family 25 member 12; Belongs to the mitochondrial carrier (TC 2.A.29) family. (712 aa)
CAPN3Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. (822 aa)
PPP2R3BEF-hand domain-containing protein. (581 aa)
PLCH2Phosphoinositide phospholipase C. (1400 aa)
CAPSLCalcyphosine like. (208 aa)
CIB1Calcium and integrin-binding protein 1; Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin- mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulat [...] (201 aa)
TCHHEF-hand domain-containing protein. (1414 aa)
ENSBTAP00000066314Uncharacterized protein. (533 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...] (181 aa)
HPCAL4Hippocalcin-like protein 4; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. (295 aa)
KCNIP3Calsenilin; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity). (279 aa)
MYLPFMyosin regulatory light chain 2, skeletal muscle isoform. (170 aa)
KCNIP2Potassium voltage-gated channel interacting protein 2. (290 aa)
SPARCSPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity. (389 aa)
GPD2Glycerol-3-phosphate dehydrogenase, mitochondrial. (727 aa)
CIB4Calcium and integrin binding family member 4. (229 aa)
MYL9Myosin regulatory light polypeptide 9. (172 aa)
RASGRP3RAS guanyl releasing protein 3. (697 aa)
S100BProtein S100-B; Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic pr [...] (92 aa)
HPCAL1Hippocalcin-like protein 1; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation; Belongs to the recoverin family. (193 aa)
ENSBTAP00000063139Uncharacterized protein. (173 aa)
CRNNEF-hand domain-containing protein. (841 aa)
DGKGDiacylglycerol kinase. (799 aa)
FKBP14Peptidylprolyl isomerase. (265 aa)
DGKADiacylglycerol kinase alpha; Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity. (734 aa)
RASEFRAS and EF-hand domain containing. (740 aa)
KCNIP1Potassium voltage-gated channel interacting protein 1. (220 aa)
PPEF1Serine/threonine-protein phosphatase with EF-hands. (658 aa)
ENSBTAP00000060233Protein S100; Belongs to the S-100 family. (105 aa)
CALM2Uncharacterized protein; Belongs to the calmodulin family. (156 aa)
CAPN2Calpain-2 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs. (703 aa)
NECAB2Oxidative stress induced growth inhibitor 1. (653 aa)
SPARCL1SPARC like 1. (658 aa)
PPP3R1Calcineurin subunit B type 1; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. (170 aa)
SPTAN1Spectrin alpha, non-erythrocytic 1. (2489 aa)
MYL10Myosin light chain 10. (283 aa)
LOC615258Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (471 aa)
CGREF1Uncharacterized protein. (492 aa)
LOC112445860Protein S100; Belongs to the S-100 family. (101 aa)
PLCD11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development. (781 aa)
ENSBTAP00000057136S_100 domain-containing protein. (636 aa)
GUCA1AGuanylyl cyclase-activating protein 1; Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure. May be involved in cone photoreceptor light response and recovery of response in bright light (By similarity). (205 aa)
SMOC2SPARC related modular calcium binding 2. (445 aa)
PLCH1Phosphoinositide phospholipase C. (1672 aa)
RCN1Reticulocalbin 1. (331 aa)
TNNC1Troponin C, slow skeletal and cardiac muscles; Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. (161 aa)
FSTL5Uncharacterized protein. (847 aa)
TNNC2Troponin C2, fast skeletal type. (162 aa)
LOC112444303Uncharacterized protein; Belongs to the parvalbumin family. (125 aa)
CRACR2ACalcium release activated channel regulator 2A. (723 aa)
CALN1Calneuron 1. (261 aa)
DSTDystonin. (3697 aa)
DGKBDiacylglycerol kinase. (803 aa)
EFHBEF-hand domain family member B. (877 aa)
PLS1Plastin-1; Actin-bundling protein in the absence of calcium. (630 aa)
CETN1Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function (By similarity). Plays a role in sperm cilia formation (By similarity); Belongs to the centrin family. (172 aa)
EPS15Epidermal growth factor receptor pathway substrate 15. (910 aa)
SRISorcin. (198 aa)
CALMCalmodulin; Belongs to the calmodulin family. (149 aa)
F1N7P3_BOVINUncharacterized protein. (495 aa)
NINLUncharacterized protein. (956 aa)
CAPS2Calcyphosine 2. (288 aa)
LOC786350Protein S100; Belongs to the S-100 family. (101 aa)
CAPN12Calpain 12; Belongs to the peptidase C2 family. (721 aa)
EHD3EH domain containing 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (535 aa)
PLCD41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration [...] (791 aa)
SMOC1SPARC related modular calcium binding 1. (445 aa)
MICU3Mitochondrial calcium uptake family member 3. (533 aa)
CHP1Calcineurin B homologous protein 1; Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane- type Na(+)/H(+) ex [...] (195 aa)
DNAH7Dynein axonemal heavy chain 7. (4024 aa)
MYL12BMyosin regulatory light chain 12B; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion. (171 aa)
GUCA1BGuanylyl cyclase-activating protein 2; Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure. May be involved in cone photoreceptor response and recovery of response in bright light (By similarity). (204 aa)
RCVRNRecoverin; Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells. Modulates light sensitivity of cone photoreceptor in dark and dim conditions (By similarity). In response to high Ca(2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin. Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells (By similarity). Improves rod photoreceptor sensitivi [...] (202 aa)
LOC112442678EF-hand domain-containing protein. (353 aa)
S100A12Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF- kappa-B signaling pathways leadi [...] (95 aa)
FKBP9Peptidyl-prolyl cis-trans isomerase FKBP9; PPIases accelerate the folding of proteins during protein synthesis. (574 aa)
MACF1Microtubule actin crosslinking factor 1. (7311 aa)
PLS3Plastin-3; Actin-bundling protein. (639 aa)
RCN3Reticulocalbin-3; Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (By similarity). Required for the proper biosynthesis and transport of pulmonary surfactant- associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3 (By similarity). By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (By similarity). Has an anti-fibrotic activity [...] (328 aa)
CABP2Calcium-binding protein 2; Required for sound encoding at inner hair cells (IHCs) synapses, likely via inhibition of the inactivation of voltage-gated calcium channel of type 1.3 (Cav1.3) in the IHCs. Required for the normal transfer of light signals through the retina. (168 aa)
ITSN2Intersectin 2. (1024 aa)
ITSN1Intersectin 1. (1716 aa)
RASGRP1RAS guanyl releasing protein 1. (797 aa)
EHD2EH-domain containing 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (543 aa)
S100ZProtein S100; Belongs to the S-100 family. (99 aa)
LETM1Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion (By similarity). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (By similarity); Belongs to the LETM1 family. (786 aa)
SCGNSecretagogin. (276 aa)
GNPTABN-acetylglucosamine-1-phosphate transferase subunits alpha and beta. (1249 aa)
S100A4Protein S100-A4. (101 aa)
PVALBParvalbumin alpha; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity). (110 aa)
GCAGrancalcin. (201 aa)
CABP7Calcium binding protein 7. (215 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity). (1291 aa)
NUCB2Nucleobindin 2. (429 aa)
FSTL4Follistatin like 4. (843 aa)
S100GProtein S100-G; Belongs to the S-100 family. (79 aa)
DUOX1Dual oxidase 1. (1553 aa)
DUOX2Dual oxidase 2. (1545 aa)
CIB3Calcium and integrin binding family member 3. (187 aa)
CETN4Centrin 4. (166 aa)
CABP5Calcium-binding protein 5; Inhibits calcium-dependent inactivation of L-type calcium channel and shifts voltage dependence of activation to more depolarized membrane potentials (By similarity). Involved in the transmission of light signals (By similarity). May positively regulate neurotransmitter vesicle endocytosis and exocytosis in a salt-dependent manner (By similarity). May play a role in the extension and network organization of neurites (By similarity). (173 aa)
MYL12AMyosin regulatory light polypeptide 9; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. (172 aa)
CALB1Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. (261 aa)
CAPN14Calpain 14; Belongs to the peptidase C2 family. (685 aa)
RCN2Reticulocalbin 2, EF-hand calcium binding domain. (317 aa)
SDF445 kDa calcium-binding protein; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. (355 aa)
PPEF2Serine/threonine-protein phosphatase with EF-hands. (753 aa)
CALM3Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
CETN3Centrin 3. (167 aa)
S100A16Protein S100-A16; Calcium-binding protein. Binds one calcium ion per monomer (By similarity). Can promote differentiation of adipocytes (in vitro) (By similarity). Overexpression in preadipocytes increases their proliferation, enhances adipogenesis and reduces insulin-stimulated glucose uptake (By similarity); Belongs to the S-100 family. (103 aa)
CALML5Calmodulin like 5. (148 aa)
SPATA21Spermatogenesis associated 21. (670 aa)
CHP2Calcineurin like EF-hand protein 2. (258 aa)
REPS1RALBP1 associated Eps domain containing 1. (795 aa)
REPS2RALBP1 associated Eps domain containing 2. (461 aa)
NKD1NKD inhibitor of WNT signaling pathway 1. (471 aa)
FKBP10Peptidyl-prolyl cis-trans isomerase FKBP10; PPIases accelerate the folding of proteins during protein synthesis. (583 aa)
PEF1Penta-EF-hand domain containing 1. (287 aa)
PPP2R3CSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma; May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B- cells. (453 aa)
NOX5NADPH oxidase 5. (803 aa)
CAPN1Calpain-1 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. (717 aa)
CAPN8Calpain 8; Belongs to the peptidase C2 family. (706 aa)
NCS1Neuronal calcium sensor 1; Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage- gated calcium channel (By similarity); Belongs to the recoverin family. (190 aa)
HPCANeuron-specific calcium-binding protein hippocalcin; Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels. May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases. (193 aa)
S100A7Protein S100-A7. (101 aa)
CETN2Centrin-2; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110 (By similarity). The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortio [...] (172 aa)
LCP1Lymphocyte cytosolic protein 1. (631 aa)
EFCAB3EF-hand calcium-binding domain-containing protein 3. (438 aa)
EHD4EH domain containing 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (540 aa)
CAPSCalcyphosin; Calcium-binding protein. May play a role in cellular signaling events (Potential). (189 aa)
MICU1Calcium uptake protein 1, mitochondrial; Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. [...] (478 aa)
P4HTMProlyl 4-hydroxylase, transmembrane. (494 aa)
S100A1Protein S100-A1; Probably acts as a Ca(2+) signal transducer. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change. This conformational change allows interaction of S1001A with specific target proteins, such as TPR- containing proteins, and the modulation of their activity. Belongs to the S-100 family. (94 aa)
CABP4Calcium-binding protein 4; May play a role in normal synaptic function, probably through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1F, shifting the activation range to more hyperpolarized voltages (By similarity). (279 aa)
RHOT2Mitochondrial Rho GTPase 2; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity). (618 aa)
NECAB3N-terminal EF-hand calcium-binding protein 3; Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid-beta (By similarity). May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3 (By similarity). (395 aa)
LOC524650Uncharacterized protein. (146 aa)
SLC25A24Calcium-binding mitochondrial carrier protein SCaMC-1; Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria (By similarity). (477 aa)
NUCB1Nucleobindin-1; Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis. Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity); Belongs to the nucleobindin family. (457 aa)
MYL7Myosin light chain 7. (175 aa)
FKBP7Peptidylprolyl isomerase. (218 aa)
CALB2Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons. (271 aa)
RASGRP2RAS guanyl-releasing protein 2; Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. (610 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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