STRINGSTRING
BIN3 BIN3 ARHGEF37 ARHGEF37 BAIAP2L2 BAIAP2L2 PICK1 PICK1 GMIP GMIP SRGAP2 SRGAP2 SH3GLB2 SH3GLB2 ARHGAP17 ARHGAP17 PACSIN2 PACSIN2 ARFIP2 ARFIP2 SNX7 SNX7 ARHGAP10 ARHGAP10 SH3GL2 SH3GL2 TRIP10 TRIP10 SNX8 SNX8 FAM92A FAM92A SNX6 SNX6 SH3BP1 SH3BP1 ASAP3 ASAP3 SNX33 SNX33 SRGAP1 SRGAP1 SNX4 SNX4 PACSIN3 PACSIN3 DNMBP DNMBP ARHGEF38 ARHGEF38 FCHSD2 FCHSD2 ARHGAP45 ARHGAP45 FAM92B FAM92B ARHGAP44 ARHGAP44 ACAP2-2 ACAP2-2 ICA1L ICA1L SNX30 SNX30 SH3GL1 SH3GL1 SNX9 SNX9 APPL1 APPL1 SH3GL3 SH3GL3 ARFIP1 ARFIP1 FCHSD1 FCHSD1 ARHGAP42 ARHGAP42 MTSS1 MTSS1 FNBP1 FNBP1 PSTPIP2 PSTPIP2 BAIAP2L1 BAIAP2L1 APPL2 APPL2 BAIAP2 BAIAP2 SNX18 SNX18 SNX5 SNX5 F1ML34_BOVIN F1ML34_BOVIN SNX2 SNX2 SNX1 SNX1 ASAP2 ASAP2 FES FES FNBP1L FNBP1L ARHGAP26 ARHGAP26 OPHN1 OPHN1 PSTPIP1 PSTPIP1 PACSIN1 PACSIN1 BIN2 BIN2 GAS7 GAS7 NOSTRIN NOSTRIN ICA1 ICA1 SH3GLB1 SH3GLB1 ARHGAP29 ARHGAP29 ACAP3 ACAP3 BIN1 BIN1 ACAP1 ACAP1 FCHO1 FCHO1 AMPH AMPH MTSS2 MTSS2 FCHO2 FCHO2 ASAP1 ASAP1 ARHGAP4 ARHGAP4 FER FER SRGAP3 SRGAP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BIN3Bridging integrator 3. (253 aa)
ARHGEF37Rho guanine nucleotide exchange factor 37. (670 aa)
BAIAP2L2Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2; Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity). (528 aa)
PICK1PRKCA-binding protein; Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive w [...] (417 aa)
GMIPGEM interacting protein. (965 aa)
SRGAP2Uncharacterized protein. (1071 aa)
SH3GLB2Endophilin-B2; Belongs to the endophilin family. (450 aa)
ARHGAP17Rho GTPase activating protein 17. (871 aa)
PACSIN2Protein kinase C and casein kinase substrate in neurons 2. (486 aa)
ARFIP2Arfaptin-2; Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network. May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2. Participates also in autophagy by regulating the starvation-depdendent trafficking of ATG9A vesicles which deliver the PI4-kinase to the autophagosome initiation site. In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG. (378 aa)
SNX7Sorting nexin 7. (472 aa)
ARHGAP10Rho GTPase-activating protein 10; GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). (810 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (352 aa)
TRIP10Thyroid hormone receptor interactor 10. (603 aa)
SNX8Sorting nexin-8; May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network (By similarity). Belongs to the sorting nexin family. (459 aa)
FAM92AProtein FAM92A; Acts as a positive regulator of ciliary hedgehog signaling (By similarity). Probable regulator of ciliogenesis involved in limb morphogenesis. In cooperation with CBY1 it is involved in the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis; Belongs to the FAM92 family. (288 aa)
SNX6Sorting nexin 6. (304 aa)
SH3BP1SH3 domain binding protein 1. (693 aa)
ASAP3ArfGAP with SH3 domain, ankyrin repeat and PH domain 3. (896 aa)
SNX33Sorting nexin. (571 aa)
SRGAP1SLIT-ROBO Rho GTPase activating protein 1. (1085 aa)
SNX4Sorting nexin-4; Involved in the regulation of endocytosis and in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation. Belongs to the sorting nexin family. (450 aa)
PACSIN3Protein kinase C and casein kinase substrate in neurons 3. (421 aa)
DNMBPDynamin binding protein. (1579 aa)
ARHGEF38Rho guanine nucleotide exchange factor 38. (781 aa)
FCHSD2FCH and double SH3 domains 2. (764 aa)
ARHGAP45Rho GTPase activating protein 45. (1135 aa)
FAM92BProtein FAM92B; May play a role in ciliogenesis. In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis. (288 aa)
ARHGAP44Rho GTPase activating protein 44. (836 aa)
ACAP2-2ArfGAP with coiled-coil, ankyrin repeat and PH domains 2. (282 aa)
ICA1LIslet cell autoantigen 1 like. (479 aa)
SNX30Sorting nexin family member 30. (437 aa)
SH3GL1Endophilin-A2; Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). Belongs to the endophilin family. (368 aa)
SNX9Sorting nexin. (617 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (708 aa)
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (347 aa)
ARFIP1ADP ribosylation factor interacting protein 1. (402 aa)
FCHSD1Uncharacterized protein. (692 aa)
ARHGAP42Rho GTPase activating protein 42. (874 aa)
MTSS1MTSS I-BAR domain containing 1. (762 aa)
FNBP1Formin binding protein 1. (668 aa)
PSTPIP2Proline-serine-threonine phosphatase interacting protein 2. (334 aa)
BAIAP2L1BAI1 associated protein 2 like 1. (511 aa)
APPL2Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2. (662 aa)
BAIAP2Brain-specific angiogenesis inhibitor 1-associated protein 2; Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling whe [...] (535 aa)
SNX18Sorting nexin. (626 aa)
SNX5Sorting nexin-5; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol lipids. Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Does not have in vitro vesicle-to-me [...] (404 aa)
F1ML34_BOVINSorting nexin; Involved in several stages of intracellular trafficking. (397 aa)
SNX2Sorting nexin-2; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called en [...] (519 aa)
SNX1Sorting nexin-1; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called en [...] (522 aa)
ASAP2ArfGAP with SH3 domain, ankyrin repeat and PH domain 2. (1008 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
FNBP1LFormin binding protein 1 like. (558 aa)
ARHGAP26Rho GTPase activating protein 26. (815 aa)
OPHN1Oligophrenin 1. (803 aa)
PSTPIP1Proline-serine-threonine phosphatase interacting protein 1. (496 aa)
PACSIN1Protein kinase C and casein kinase substrate in neurons protein 1; Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell corte [...] (459 aa)
BIN2Bridging integrator 2. (519 aa)
GAS7Growth arrest specific 7. (476 aa)
NOSTRINNostrin; Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane. (506 aa)
ICA1Islet cell autoantigen 1. (509 aa)
SH3GLB1Endophilin-B1; May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation. Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2). Associated with PI3KC3-C2 d [...] (366 aa)
ARHGAP29Rho GTPase-activating protein 29; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho (By similarity). In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis (By similarity). (1269 aa)
ACAP3ArfGAP with coiled-coil, ankyrin repeat and PH domains 3. (833 aa)
BIN1Bridging integrator 1. (706 aa)
ACAP1Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration (By similarity). (760 aa)
FCHO1FCH domain only 1. (887 aa)
AMPHAmphiphysin. (853 aa)
MTSS2MTSS I-BAR domain containing 2. (769 aa)
FCHO2FCH domain only 2. (321 aa)
ASAP1Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1; Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. Plays a role in ciliogenesis (By similarity). May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. (1176 aa)
ARHGAP4Rho GTPase activating protein 4. (951 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
SRGAP3SLIT-ROBO Rho GTPase activating protein 3. (1099 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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