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| | PNLIPRP3 | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (469 aa) |
| | LOC537848 | Uncharacterized protein. (359 aa) |
| | MEST | Mesoderm-specific transcript homolog protein. (335 aa) |
| | NLGN4X | COesterase domain-containing protein. (815 aa) |
| | PNLIPRP1 | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (443 aa) |
| | PNLIP | Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (465 aa) |
| | ACHE | Acetylcholinesterase; Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft; Belongs to the type-B carboxylesterase/lipase family. (615 aa) |
| | ACOT2 | Uncharacterized protein. (476 aa) |
| | ABHD13 | Abhydrolase domain containing 13. (337 aa) |
| | ACOT4 | Uncharacterized protein. (424 aa) |
| | ABHD10 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Belongs to the AB hydrolase superfamily. (306 aa) |
| | PAFAH2 | Platelet-activating factor acetylhydrolase 2, cytoplasmic; Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the plasma-type enzyme. (392 aa) |
| | DPP10 | Dipeptidyl peptidase like 10; Belongs to the peptidase S9B family. (675 aa) |
| | LIPC | Hepatic triacylglycerol lipase; Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin (By similarity). (500 aa) |
| | BPHL | Biphenyl hydrolase like. (291 aa) |
| | LIPF | Gastric triacylglycerol lipase. (397 aa) |
| | ABHD17B | Abhydrolase domain containing 17B. (288 aa) |
| | ABHD1 | Protein ABHD1. (404 aa) |
| | CPVL | Carboxypeptidase; Belongs to the peptidase S10 family. (593 aa) |
| | PLA2G15 | Group XV phospholipase A2; Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid. Has high activity with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2- dioleoyl-sn-glycero-3-phosphocholine (DOPC), catalyzing the transfer of oleic acid to N-acetyl-sphingosine. Required for normal phospholipid degradation in alveolar and peritoneal macrophages and in spleen (By similarity). (407 aa) |
| | SCPEP1 | Carboxypeptidase; Belongs to the peptidase S10 family. (448 aa) |
| | FAP | Antiplasmin-cleaving enzyme FAP, soluble form; Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2. Degrade also gelatin, heat-denatured type I collagen, but not native collagen type I and IV, [...] (760 aa) |
| | DAGLB | Diacylglycerol lipase beta. (735 aa) |
| | OVCA2 | Esterase OVCA2; Belongs to the LovG family. (227 aa) |
| | PPME1 | Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme (By similarity); Belongs to the AB hydrolase superfamily. (380 aa) |
| | CTSA | Lysosomal protective protein 20 kDa chain; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins (By similarity). (478 aa) |
| | ABHD8 | Protein ABHD8; Belongs to the AB hydrolase superfamily. (432 aa) |
| | ADPRH | Phospholipase A1 member A; Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production (By similarity); Belongs to the AB hydrolase superfamily. Lipase family. (491 aa) |
| | DNAL1 | Dynein light chain 1, axonemal. (433 aa) |
| | LOC512541 | Uncharacterized protein. (416 aa) |
| | BCHE | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity). (643 aa) |
| | CES5A | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (576 aa) |
| | PNLIPRP2 | Pancreatic lipase-related protein 2; Lipase with broad substrate specificity. Can hydrolyze both phospholipids and galactolipids. Acts preferentially on monoglycerides, phospholipids and galactolipids. Contributes to milk fat hydrolysis (By similarity). (469 aa) |
| | AADAC | Arylacetamide deacetylase; Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity (By similarity). (414 aa) |
| | APEH | Acylamino-acid-releasing enzyme; This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser; Belongs to the peptidase S9C family. (730 aa) |
| | F1N7E4_BOVIN | Uncharacterized protein. (107 aa) |
| | LOC530653 | Uncharacterized protein. (484 aa) |
| | TMEM53 | Transmembrane protein 53. (278 aa) |
| | LPL | Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries (By similarity). Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. Belongs to the AB hydrolase superfamily. Lipase family. (478 aa) |
| | LIPK | Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (396 aa) |
| | LIPM | Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (415 aa) |
| | PPT1 | Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons. (336 aa) |
| | DAGLA | Diacylglycerol lipase alpha. (1041 aa) |
| | DPP8 | Dipeptidyl peptidase 8; Belongs to the peptidase S9B family. (898 aa) |
| | EPHX2 | Epoxide hydrolase 2. (555 aa) |
| | AADACL3 | Arylacetamide deacetylase like 3. (399 aa) |
| | LYPLAL1 | Lysophospholipase like 1. (232 aa) |
| | FASN | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. (2515 aa) |
| | PREP | Prolyl endopeptidase; Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. (716 aa) |
| | ABHD6 | Monoacylglycerol lipase ABHD6; Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (By similarity). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and [...] (337 aa) |
| | ABHD4 | (Lyso)-N-acylphosphatidylethanolamine lipase; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N- acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatid [...] (355 aa) |
| | PREPL | Prolyl endopeptidase like. (727 aa) |
| | LCAT | Lecithin-cholesterol acyltransferase. (440 aa) |
| | FAM135B | DUF676 domain-containing protein. (1278 aa) |
| | ABHD14B | Protein ABHD14B; Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription (By similarity). (210 aa) |
| | ABHD3 | Phospholipase ABHD3; Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids. (411 aa) |
| | PLA2G7 | Platelet-activating factor acetylhydrolase; Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids; Belongs to the AB hydrolase superfamily. Lipase family. (444 aa) |
| | ABHD2 | Monoacylglycerol lipase ABHD2; Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1- arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2A [...] (425 aa) |
| | ABHD16B | Chromosome 20 open reading frame 135 ortholog. (470 aa) |
| | DPP7 | Dipeptidyl peptidase 7. (488 aa) |
| | SERAC1 | Protein SERAC1; Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be involved in the transacylation-acylation reaction to produce phosphatidylglycerol-36:1. May be involved in bis(monoacylglycerol)phosphate biosynthetic pathway (By similarity). Belongs to the SERAC1 family. (654 aa) |
| | LIPG | Lipase G, endothelial type. (500 aa) |
| | CMBL | Carboxymethylenebutenolidase homolog. (248 aa) |
| | DPP9 | Dipeptidyl peptidase 9; Belongs to the peptidase S9B family. (902 aa) |
| | FAM135A | Family with sequence similarity 135 member A. (1544 aa) |
| | MGLL | Monoglyceride lipase. (437 aa) |
| | ENSBTAP00000059016 | Abhydrolase_3 domain-containing protein. (204 aa) |
| | LOC528748 | Uncharacterized protein. (396 aa) |
| | NDRG1 | Protein NDRG1; Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking notably of the Schwann cell and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulat [...] (415 aa) |
| | ENSBTAP00000059706 | Uncharacterized protein. (176 aa) |
| | CES4A | Carboxylesterase 4A; Probable carboxylesterase; Belongs to the type-B carboxylesterase/lipase family. (570 aa) |
| | EPHX3 | Epoxide hydrolase 3. (533 aa) |
| | ABHD11 | Protein ABHD11; Belongs to the AB hydrolase superfamily. (361 aa) |
| | LIPH | Lipase H. (457 aa) |
| | ABHD17A | Alpha/beta hydrolase domain-containing protein 17A; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS. Has depalmitoylating activity towards DLG4/PSD95. May have depalmitoylating activity towards MAP6; Belongs to the AB hydrolase superfamily. ABHD17 family. (310 aa) |
| | TEX30 | Testis-expressed protein 30. (224 aa) |
| | ABHD15 | Abhydrolase domain containing 15. (468 aa) |
| | LIPN | Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (397 aa) |
| | CEL | Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFA). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity); Belongs to the type-B ca [...] (599 aa) |
| | LOC508916 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (566 aa) |
| | BREH1 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa) |
| | CES2 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (553 aa) |
| | ABHD5 | Abhydrolase domain-containing protein 5. (348 aa) |
| | DPP6 | Dipeptidyl aminopeptidase-like protein 6; Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity. Belongs to the peptidase S9B family. (863 aa) |
| | PGAP1 | GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI- anchored proteins from the endoplasmic reticulum to the Golgi. (922 aa) |
| | NLGN2 | Neuroligin 2. (835 aa) |
| | NCEH1 | Neutral cholesterol ester hydrolase 1; Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity); Belongs to the 'GDXG' lipolytic enzyme family. (408 aa) |
| | LYPLA1 | Acyl-protein thioesterase 1; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity (By similarity); Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. (339 aa) |
| | LIPE | Hormone-sensitive lipase; In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production; Belongs to the 'GDXG' lipolytic enzyme family. (802 aa) |
| | EPHX1 | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. (451 aa) |
| | SERHL2 | Serine hydrolase like 2. (328 aa) |
| | ESD | S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (292 aa) |
| | ENSBTAP00000065320 | Abhydrolase_2 domain-containing protein. (51 aa) |
| | AADACL4 | Arylacetamide deacetylase like 4. (394 aa) |
| | EPHX4 | Epoxide hydrolase 4. (362 aa) |
| | NDRG4 | NDRG family member 4. (411 aa) |
| | LIPJ | Lipase family member J. (365 aa) |
| | ENSBTAP00000064367 | Uncharacterized protein. (285 aa) |
| | ABHD18 | Abhydrolase domain containing 18. (464 aa) |
| | TG | Thyroglobulin; Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (By similarity). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling (By similarity). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (By similarity). Belongs to the type-B carboxylesterase/lipase family. (2770 aa) |
| | NDRG3 | Protein NDRG3; Belongs to the NDRG family. (388 aa) |
| | LYPLA2 | Lysophospholipase II. (231 aa) |
| | PPT2 | Lysosomal thioesterase PPT2; Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins (By similarity). (311 aa) |
| | ABHD12 | Lysophosphatidylserine lipase ABHD12; Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (By similarity). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase act [...] (485 aa) |
| | KANSL3 | KAT8 regulatory NSL complex subunit 3. (956 aa) |
| | RBBP9 | RB binding protein 9, serine hydrolase. (186 aa) |
| | ENSBTAP00000072701 | Abhydrolase_3 domain-containing protein. (199 aa) |
| | SPG21 | Maspardin; May play a role as a negative regulatory factor in CD4- dependent T-cell activation. (395 aa) |
| | ACOT2-2 | ACOT2 protein. (464 aa) |
| | TMCO4 | Transmembrane and coiled-coil domains 4. (632 aa) |
| | FAM172A | Family with sequence similarity 172 member A. (416 aa) |
| | NDRG2 | Protein NDRG2; Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation (By similarity). (357 aa) |
| | CES1 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa) |
| | ABHD16A | Phosphatidylserine lipase ABHD16A; Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase (By similarity). Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z-octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy- Delta(12,14)-prostaglandin J2 (15d-PGJ(2)-G) (By similarity). (639 aa) |
| | LIPA | Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (400 aa) |
| | NLGN3 | Neuroligin 3. (848 aa) |
| | OLAH | Oleoyl-ACP hydrolase. (137 aa) |
| | G3MWX2_BOVIN | Abhydrolase_2 domain-containing protein. (234 aa) |
| | LDAH | Lipid droplet associated hydrolase. (325 aa) |
| | ABHD12B | Abhydrolase domain containing 12B. (354 aa) |
| | LIPI | LOC617574 protein. (162 aa) |
| | ABHD14A | Abhydrolase domain containing 14A. (180 aa) |
| | CES3 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (573 aa) |
| | DPP4 | Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...] (765 aa) |
| | AFMID | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (315 aa) |
| | PRSS16 | Serine protease 16. (516 aa) |
| | PRCP | Lysosomal Pro-X carboxypeptidase; Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH (By similarity); Belongs to the peptidase S28 family. (499 aa) |
| | ABHD17C | Alpha/beta hydrolase domain-containing protein 17C; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS and DLG4/PSD95. Belongs to the AB hydrolase superfamily. ABHD17 family. (329 aa) |
| | NLGN1 | Neuroligin 1. (823 aa) |
