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| | TXNL4A | Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. (142 aa) |
| | MRPS25 | 28S ribosomal protein S25, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mS25 family. (173 aa) |
| | FAF1 | Fas (TNFRSF6) associated factor 1. (650 aa) |
| | TXNDC15 | Thioredoxin domain containing 15. (403 aa) |
| | TXNDC11 | Thioredoxin domain-containing protein 11; May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation (By similarity). (957 aa) |
| | NDUFA2 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (99 aa) |
| | CLIC3 | Chloride intracellular channel 3. (237 aa) |
| | UBXN4 | UBX domain-containing protein 4; Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD. (508 aa) |
| | GLRX2 | Glutaredoxin-2, mitochondrial; Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylat [...] (157 aa) |
| | PDILT | Protein disulfide isomerase like, testis expressed. (578 aa) |
| | GSTM1 | Glutathione S-transferase Mu 1; Belongs to the GST superfamily. (218 aa) |
| | NXNL1 | Nucleoredoxin like 1. (218 aa) |
| | HPGDS | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. (199 aa) |
| | PDIA4 | Protein disulfide-isomerase A4. (643 aa) |
| | PDIA3 | Protein disulfide-isomerase A3. (505 aa) |
| | TXNDC2 | Thioredoxin domain containing 2. (545 aa) |
| | C7H5orf63 | Glutaredoxin-like protein; Belongs to the glutaredoxin family. (171 aa) |
| | GPX7 | Glutathione peroxidase 7; Belongs to the glutathione peroxidase family. (186 aa) |
| | PDIA5 | Protein disulfide-isomerase A5; Belongs to the protein disulfide isomerase family. (521 aa) |
| | CASQ1 | Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (395 aa) |
| | PRXL2C | Peroxiredoxin-like 2C; May regulate positively ERK1/2 signaling and AKT1 activation leading to HIF1A up-regulation with an increased expression of glycolysis genes and enhanced glycolysis. (228 aa) |
| | PRXL2A | Peroxiredoxin-like 2A; Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass. Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway. (218 aa) |
| | GSTA5 | Glutathione S-transferase. (222 aa) |
| | MIEN1 | Migration and invasion enhancer 1; Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process (By similarity); Belongs to the SelWTH family. (115 aa) |
| | GPX8 | Probable glutathione peroxidase 8; Belongs to the glutathione peroxidase family. (209 aa) |
| | NXNL2 | Nucleoredoxin like 2. (156 aa) |
| | AGR2 | Anterior gradient 2, protein disulphide isomerase family member. (175 aa) |
| | E1BKD8_BOVIN | Uncharacterized protein. (224 aa) |
| | SH3BGR | SH3 domain binding glutamate rich protein. (208 aa) |
| | QSOX2 | Sulfhydryl oxidase. (699 aa) |
| | PDCL | Phosducin-like protein; Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers. Acts also as a positive regulator of hedgehog signaling and regulates ciliary function. (301 aa) |
| | TMX2 | Thioredoxin-related transmembrane protein 2. (296 aa) |
| | GSTT2 | Uncharacterized protein; Belongs to the GST superfamily. (281 aa) |
| | SELENOM | Selenoprotein M. (143 aa) |
| | TXN | Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] (105 aa) |
| | SELENOT | Thioredoxin reductase-like selenoprotein T; Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress ans cell death (By similarity). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation (By similarity). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose [...] (195 aa) |
| | GSTA2 | Glutathione S-transferase A2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. (223 aa) |
| | GRXCR1 | Glutaredoxin and cysteine rich domain containing 1. (290 aa) |
| | NME8 | NME/NM23 family member 8. (410 aa) |
| | PDIA2 | Rho GDP-dissociation inhibitor 3. (736 aa) |
| | TMX4 | Thioredoxin related transmembrane protein 4. (348 aa) |
| | CLIC4 | Chloride intracellular channel protein 4; Can insert into membranes and form chloride ion channels. (253 aa) |
| | SELENOV | Selenoprotein V. (381 aa) |
| | GLRX | Glutaredoxin-1; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins; Belongs to the glutaredoxin family. (106 aa) |
| | F1MIJ5_BOVIN | Glutaredoxin domain-containing protein. (106 aa) |
| | F1MB80_BOVIN | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (92 aa) |
| | E1B773_BOVIN | Glutaredoxin domain-containing protein. (106 aa) |
| | FAF2 | FAS-associated factor 2; Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. By controlling the steady- state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis. (445 aa) |
| | NDUFV2 | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (249 aa) |
| | DIO3 | Thyroxine 5-deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development. (301 aa) |
| | GPX3 | Glutathione peroxidase 3; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. (226 aa) |
| | FAXC | Failed axon connections homolog, metaxin like GST domain containing. (409 aa) |
| | AGR3 | Anterior gradient 3, protein disulphide isomerase family member. (166 aa) |
| | MAGT1 | Magnesium transporter 1. (335 aa) |
| | G3MZ04_BOVIN | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (99 aa) |
| | PTGES2 | Prostaglandin E synthase 2 truncated form; Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2); Belongs to the GST superfamily. (431 aa) |
| | CLIC5 | Chloride intracellular channel protein 5; Required for normal hearing. It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti. Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture. Plays a role in formation of the lens suture in the eye, which is important for normal optical propert [...] (467 aa) |
| | ENSBTAP00000057322 | Glutaredoxin domain-containing protein. (85 aa) |
| | ENSBTAP00000057361 | Thioredoxin domain-containing protein. (224 aa) |
| | GSTM3 | Glutathione S-transferase. (240 aa) |
| | GPX1 | Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown. (205 aa) |
| | GSTP1-2 | Glutathione S-transferase P; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity); Belongs to the GST superfamily. Pi family. (240 aa) |
| | SH3BGRL2 | SH3 domain-binding glutamic acid-rich-like protein 2. (135 aa) |
| | SELENOF | Selenoprotein F; May be involved in redox reactions associated with the formation of disulfide bonds (By similarity). May contribute to the quality control of protein folding in the endoplasmic reticulum. May regulate protein folding by enhancing the catalytic activity of UGGT1/UGCGL1 and UGGT2/UGCGL2 (By similarity). (162 aa) |
| | ENSBTAP00000071579 | UBX domain-containing protein. (462 aa) |
| | LOC112441537 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. (219 aa) |
| | GSTZ1 | Glutathione S-transferase zeta 1; Belongs to the GST superfamily. (445 aa) |
| | ENSBTAP00000064501 | ERp29_N domain-containing protein. (194 aa) |
| | TXNDC5 | Uncharacterized protein. (437 aa) |
| | SPATA20 | Spermatogenesis-associated protein 20; May play a role in fertility regulation. (789 aa) |
| | GSTA4 | Glutathione S-transferase A4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Alpha family. (303 aa) |
| | ENSBTAP00000062192 | Uncharacterized protein. (336 aa) |
| | GSTM1-2 | Uncharacterized protein. (266 aa) |
| | TXNDC16 | Thioredoxin domain containing 16. (818 aa) |
| | TXNDC17 | DUF953 domain-containing protein. (123 aa) |
| | ENSBTAP00000072903 | Glutaredoxin domain-containing protein. (116 aa) |
| | GSTO1 | Uncharacterized protein; Belongs to the GST superfamily. (241 aa) |
| | PDC | Phosducin; Inhibits the transcriptional activation activity of the cone- rod homeobox CRX (By similarity). May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism; Belongs to the phosducin family. (245 aa) |
| | GSTO2 | Glutathione S-transferase omega 2; Belongs to the GST superfamily. (244 aa) |
| | NHLRC2 | NHL repeat-containing protein 2; Required for normal embryonic development. (726 aa) |
| | PRDX1 | Peroxiredoxin-1; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron diffe [...] (199 aa) |
| | GSTP1 | Glutathione S-transferase P; Belongs to the GST superfamily. (191 aa) |
| | MRPL43 | 39S ribosomal protein L43, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL43 family. (159 aa) |
| | DNAJC16 | DNAJC16 protein. (782 aa) |
| | GSTA3 | Glutathione S-transferase, alpha 3. (222 aa) |
| | PDIA6 | Protein disulfide isomerase family A member 6; Belongs to the protein disulfide isomerase family. (440 aa) |
| | CLIC6 | Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (655 aa) |
| | PRXL2B | Prostamide/prostaglandin F synthase; Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha) (By similarity); Belongs to the peroxiredoxin-like PRXL2 family. Prostamide/prostaglandin F synthase subfamily. (201 aa) |
| | DIO2 | Type II iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development. (269 aa) |
| | G8JKV3_BOVIN | Glutaredoxin domain-containing protein. (106 aa) |
| | NXN | Nucleoredoxin; Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity). (435 aa) |
| | GSTT4 | Uncharacterized protein; Belongs to the GST superfamily. (241 aa) |
| | TXN2 | Thioredoxin, mitochondrial; Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity; Belongs to the thioredoxin family. (166 aa) |
| | PRDX6 | Peroxiredoxin-6; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role [...] (224 aa) |
| | GLRX3 | Glutaredoxin-3; Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (By similarity). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity (By similarity). (334 aa) |
| | GSTT1 | Glutathione S-transferase theta-1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Also binds steroids, bilirubin, carcinogens and numerous organic anions. Has dichloromethane dehalogenase activity; Belongs to the GST superfamily. Theta family. (240 aa) |
| | P4HB | Protein disulfide-isomerase; This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chape [...] (565 aa) |
| | PDCL2 | Phosducin-like protein 2; May play a role in germ cell maturation; Belongs to the phosducin family. (243 aa) |
| | SCO1 | Protein SCO1 homolog, mitochondrial; Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Not required for the synthesis of MT-CO2/COX2 but plays a crucial role in stabilizing MT- CO2/COX2 during its subsequent maturation. Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Plays an important role in the regulation of copper homeostasis by controlling the abundance and cell membrane localization of copper transporter CTR1. (310 aa) |
| | ENSBTAP00000073566 | Uncharacterized protein. (244 aa) |
| | GDAP1L1 | Ganglioside-induced differentiation-associated protein 1-like 1. (367 aa) |
| | ENSBTAP00000074241 | DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. (793 aa) |
| | ENSBTAP00000074273 | Glutaredoxin domain-containing protein. (125 aa) |
| | ENSBTAP00000074307 | Uncharacterized protein; Belongs to the protein disulfide isomerase family. (440 aa) |
| | TXNL1 | Thioredoxin like 1. (292 aa) |
| | ENSBTAP00000069064 | 1-cysPrx_C domain-containing protein. (92 aa) |
| | GSTA1 | Glutathione S-transferase. (291 aa) |
| | QSOX1 | Sulfhydryl oxidase. (791 aa) |
| | GPX4 | Phospholipid hydroperoxide glutathione peroxidase; Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation. Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron- dependent accumulation of lipid reactive oxygen species. The presence of s [...] (197 aa) |
| | ERP44 | Endoplasmic reticulum resident protein 44; Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum (By similarity). (419 aa) |
| | ERP27 | Endoplasmic reticulum resident protein 27; Specifically binds unfolded proteins and may recruit protein disulfide isomerase PDIA3 to unfolded substrates. Binds protein substrates via a hydrophobic pocket in the C-terminal domain. May play a role in the unfolded stress response. (301 aa) |
| | ENSBTAP00000064701 | Uncharacterized protein. (95 aa) |
| | PRDX4 | Peroxiredoxin-4; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. (274 aa) |
| | TXNL4B | Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. (149 aa) |
| | ERP29 | Endoplasmic reticulum resident protein 29; Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the ER (By similarity). (258 aa) |
| | TXNDC9 | Thioredoxin domain-containing protein 9; Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin. (226 aa) |
| | TMX3 | Thioredoxin related transmembrane protein 3. (454 aa) |
| | UBXN7 | UBX domain-containing protein 7. (489 aa) |
| | DNAJC10 | DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. (793 aa) |
| | PRDX5 | Peroxiredoxin-5, mitochondrial; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. (219 aa) |
| | PRDX3 | Thioredoxin-dependent peroxide reductase, mitochondrial; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. (257 aa) |
| | TUSC3 | Tumor suppressor candidate 3; Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfide [...] (347 aa) |
| | SH3BGRL3 | SH3 domain-binding glutamic acid-rich-like protein 3; Could act as a modulator of glutaredoxin biological activity. Belongs to the SH3BGR family. (93 aa) |
| | GSTK1 | Glutathione S-transferase kappa. (226 aa) |
| | PDCL3 | Phosducin-like protein 3; Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (By similarity). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (By similarity). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (By similarity); Belongs to the phosducin family. (240 aa) |
| | TXNDC8 | Thioredoxin; Belongs to the thioredoxin family. (105 aa) |
| | SH3BGRL | SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family. (114 aa) |
| | CLIC2 | Chloride intracellular channel 2. (247 aa) |
| | TXNDC12 | Thioredoxin domain-containing protein 12; Possesses significant protein thiol-disulfide oxidase activity. (172 aa) |
| | TMX1 | Thioredoxin-related transmembrane protein 1; May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. (278 aa) |
| | CASQ2 | Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (431 aa) |
| | E1BKQ7_BOVIN | Glutaredoxin domain-containing protein. (91 aa) |
| | TXNRD3 | Thioredoxin reductase 3. (596 aa) |
| | EEF1G | Elongation factor 1-gamma; Probably plays a role in anchoring the complex to other cellular components. (440 aa) |
| | GPX5 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. (199 aa) |
| | PRDX2 | Peroxiredoxin-2; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2); Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. (199 aa) |
| | GDAP1 | Ganglioside-induced differentiation-associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission; Belongs to the GST superfamily. (358 aa) |
| | SCO2 | Protein SCO2 homolog, mitochondrial; Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2. (266 aa) |
| | LOC100295687 | Glutathione S-transferase Mu 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Protects against the thiol-mediated metal-catalysed oxidative inactivation of enzymes. Belongs to the GST superfamily. Mu family. (218 aa) |
| | NME9 | Thioredoxin domain containing 6; Belongs to the NDK family. (342 aa) |
| | LOC785216 | Uncharacterized protein. (344 aa) |
| | GLRX5 | Glutaredoxin 5. (158 aa) |
| | CLIC1 | Chloride intracellular channel protein 1; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions (By similarity). (241 aa) |
