Your Input: | |
| | NSDHL | Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis. (356 aa) |
| | VAT1L | Vesicle amine transport protein 1 homolog (T. californica)-like. (419 aa) |
| | SDR16C5 | Short chain dehydrogenase/reductase family 16C member 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (321 aa) |
| | CBR3 | Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (277 aa) |
| | GFOD2 | Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly; Belongs to the Gfo/Idh/MocA family. (385 aa) |
| | GRHPR | Glyoxylate and hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (328 aa) |
| | DECR1 | 2,4-dienoyl-CoA reductase 1. (329 aa) |
| | RDH10 | Retinol dehydrogenase 10; Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol (By similarity). (341 aa) |
| | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)]; Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa) |
| | DHRS7 | Dehydrogenase/reductase (SDR family) member 7; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (339 aa) |
| | HSD17B8 | Hydroxysteroid (17-beta) dehydrogenase 8. (259 aa) |
| | CBR4 | Carbonyl reductase family member 4; The heterotetramer with HSD17B8 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis. Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD. The homotetramer has NADPH-dependent quinone reductase activity. Both homotetramer and the heterotetramer have broad in vitro substrate specificity and can reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o- quinones and p-quinones; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (237 aa) |
| | RDH13 | Retinol dehydrogenase 13 (All-trans/9-cis); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (335 aa) |
| | STEAP4 | STEAP4 metalloreductase. (470 aa) |
| | DHRS3 | Short-chain dehydrogenase/reductase 3; Catalyzes the reduction of all-trans-retinal to all-trans- retinol in the presence of NADPH; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa) |
| | NOXRED1 | NADP dependent oxidoreductase domain containing 1. (357 aa) |
| | TDH | L-threonine 3-dehydrogenase, mitochondrial; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate, mediating L-threonine catabolism. (373 aa) |
| | HSD17B13 | Hydroxysteroid (17-beta) dehydrogenase 13; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (300 aa) |
| | KCNU1 | Potassium calcium-activated channel subfamily U member 1. (1136 aa) |
| | DHDH | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase. (335 aa) |
| | MGC127133 | 20-beta-hydroxysteroid dehydrogenase-like; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (286 aa) |
| | LOC508455 | 20beta-hydroxysteroid dehydrogenase type 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (315 aa) |
| | HSDL2 | Hydroxysteroid dehydrogenase-like protein 2; Has apparently no steroid dehydrogenase activity. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (418 aa) |
| | SDR39U1 | Epimerase family protein SDR39U1; Putative NADP-dependent oxidoreductase. (294 aa) |
| | SDR42E1 | Short-chain dehydrogenase/reductase family 42E member 1. (393 aa) |
| | CRYZL1 | Quinone oxidoreductase-like protein 1; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. (349 aa) |
| | LDHA | L-lactate dehydrogenase A chain. (332 aa) |
| | KCNMA1 | Calcium-activated potassium channel subunit alpha-1; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the c [...] (1166 aa) |
| | AHCYL1 | Adenosylhomocysteinase like 1. (530 aa) |
| | DCXR | Dicarbonyl/L-xylulose reductase. (244 aa) |
| | SDR16C6 | Short-chain dehydrogenase/reductase family 16C member 6; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (316 aa) |
| | QDPR | Dihydropteridine reductase; The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (242 aa) |
| | PYROXD1 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1; Probable FAD-dependent oxidoreductase; involved in the cellular oxidative stress response (By similarity). Required for normal sarcomere structure and muscle fiber integrity (By similarity). (518 aa) |
| | MGC152281 | Uncharacterized protein. (330 aa) |
| | MTHFD1L | Monofunctional C1-tetrahydrofolate synthase, mitochondrial; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2; In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. (975 aa) |
| | F1N4W7_BOVIN | NmrA domain-containing protein. (288 aa) |
| | AK7 | Adenylate kinase 7. (724 aa) |
| | EHHADH | Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase. (723 aa) |
| | H6PD | Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. (804 aa) |
| | MTHFD2L | Uncharacterized protein. (347 aa) |
| | HSD17B1 | Hydroxysteroid (17-beta) dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa) |
| | LOC515578 | Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (328 aa) |
| | DCXR-2 | L-xylulose reductase. (244 aa) |
| | LOC100299281 | Quinone oxidoreductase-like protein 2; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. (392 aa) |
| | RDH5 | Retinol dehydrogenase 5; Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner. Has no activity towards all-trans retinal. Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE) (By similarity). Also recognizes steroids (androsterone, androstanediol) as its substrates (By similarity). Belongs to the short-chain dehydrogenases/reductases (SDR) family. (318 aa) |
| | STEAP3 | STEAP3 metalloreductase. (541 aa) |
| | DHRSX | Uncharacterized protein. (156 aa) |
| | KCNT2 | Potassium sodium-activated channel subfamily T member 2. (1142 aa) |
| | TGDS | dTDP-D-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (358 aa) |
| | ADH6-2 | Uncharacterized protein. (387 aa) |
| | ENSBTAP00000058833 | Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (169 aa) |
| | GFOD1 | Glucose-fructose oxidoreductase domain containing 1. (390 aa) |
| | CRYZ | Zeta-crystallin; Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding (By similarity). Has minimal or no quinone reductase activity. Binds strongly to single-stranded DNA. (330 aa) |
| | RTN4IP1 | Reticulon-4-interacting protein 1, mitochondrial; Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury. (396 aa) |
| | DECR2 | 2,4-dienoyl-CoA reductase 2. (291 aa) |
| | ME2 | Malic enzyme. (607 aa) |
| | ACLY | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1101 aa) |
| | ENSBTAP00000060488 | L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa) |
| | WWOX | WW domain containing oxidoreductase. (497 aa) |
| | PYCR2 | Pyrroline-5-carboxylate reductase 2; Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (By similarity). Involved in cellular response to oxidative stress (By similarity); Belongs to the pyrroline-5-carboxylate reductase family. (323 aa) |
| | TSTA3 | Tissue specific transplantation antigen P35B. (525 aa) |
| | ENSBTAP00000062682 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (309 aa) |
| | GAPDH | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (376 aa) |
| | ENSBTAP00000063081 | Uncharacterized protein. (313 aa) |
| | CTBP1 | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (441 aa) |
| | HSDL1 | Inactive hydroxysteroid dehydrogenase-like protein 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. (330 aa) |
| | DHRS12 | Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase. (376 aa) |
| | SPR | Sepiapterin reductase; Catalyzes the final one or two reductions in tetra- hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin. (299 aa) |
| | NMRAL1 | NmrA-like family domain-containing protein 1; Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer b [...] (299 aa) |
| | CRYL1 | Lambda-crystallin homolog. (322 aa) |
| | GPD1L | Glycerol-3-phosphate dehydrogenase [NAD(+)]. (351 aa) |
| | SORD | Sorbitol dehydrogenase; Polyol dehydrogenase that catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcohols. Is mostly active with xylitol, D-sorbitol (D-glucitol) and L-iditol as substrates, leading to the C2-oxidized products D-xylulose, D-fructose and L-sorbose, respectively. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (By similarity). Cannot u [...] (363 aa) |
| | ENSBTAP00000068586 | L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa) |
| | LDHB | L-lactate dehydrogenase B chain; Belongs to the LDH/MDH superfamily. LDH family. (341 aa) |
| | HADHA | Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family. (771 aa) |
| | LOC100139075 | Uncharacterized protein. (306 aa) |
| | MDH1 | Malate dehydrogenase, cytoplasmic. (334 aa) |
| | MDH1B | Putative malate dehydrogenase 1B; Belongs to the LDH/MDH superfamily. MDH type 2 family. (522 aa) |
| | G6PD | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (555 aa) |
| | LOC112441473 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (356 aa) |
| | LOC112441469 | L-xylulose reductase; Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (244 aa) |
| | PYCR1 | Pyrroline-5-carboxylate reductase 1, mitochondrial; Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress. Belongs to the pyrroline-5-carboxylate reductase family. (351 aa) |
| | LOC100138638 | Uncharacterized protein. (313 aa) |
| | CBR1 | Carbonyl reductase [NADPH] 1; NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2- alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S- nitrosoglutathione (By similarity) [...] (281 aa) |
| | NNT | NAD(P) transhydrogenase, mitochondrial; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity). May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland (By similarity). In the N-terminal section; belongs to the AlaDH/PNT family. (1086 aa) |
| | ENSBTAP00000072976 | Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. (334 aa) |
| | ENSBTAP00000074444 | Glycerol-3-phosphate dehydrogenase [NAD(+)]. (351 aa) |
| | PTGR1 | Prostaglandin reductase 1; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha. Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4 (By similarity). (329 aa) |
| | FAR2 | Fatty acyl-CoA reductase 2; Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity can be observed with shorter fatty acyl-CoA substrates. It may play a role in the production of ether lipids/plasmalogens and wax monoesters which synthesis requires fatty alcohols as substrates. (515 aa) |
| | HSD17B6 | 17-beta-hydroxysteroid dehydrogenase type 6; NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17- beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to [...] (317 aa) |
| | GMDS | GDP-mannose 4,6-dehydratase. (372 aa) |
| | AASS | Alpha-aminoadipic semialdehyde synthase, mitochondrial; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine- oxoglutarate reductase and saccharopine dehydrogenase activity, respectively (By similarity). (926 aa) |
| | MAT2B | Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. Can bind NADP (in vitro). (334 aa) |
| | RDH12 | Retinol dehydrogenase 12; Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans- retinal. Shows very weak activity towards 13-cis-retinol. Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal. May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation. Has no dehydrogenase activity towards steroids. (316 aa) |
| | SDR42E2 | Short chain dehydrogenase/reductase family 42E, member 2. (619 aa) |
| | BLVRA | Biliverdin reductase A; Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor; Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily. (296 aa) |
| | HTATIP2 | HIV-1 Tat interactive protein 2, 30kDa. (242 aa) |
| | SDR9C7 | Short-chain dehydrogenase/reductase family 9C member 7; Displays weak conversion of all-trans-retinal to all-trans- retinol in the presence of NADH. Has apparently no steroid dehydrogenase activity (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (313 aa) |
| | DHRS13 | Dehydrogenase/reductase SDR family member 13; Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (377 aa) |
| | PGD | 6-phosphogluconate dehydrogenase, decarboxylating; Belongs to the 6-phosphogluconate dehydrogenase family. (559 aa) |
| | UEVLD | UEV and lactate/malate dehyrogenase domains. (471 aa) |
| | UGDH | UDP-glucose 6-dehydrogenase; Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (By similarity). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). (494 aa) |
| | ADH7 | Alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide. (379 aa) |
| | GAPDHS | Glyceraldehyde-3-phosphate dehydrogenase, testis-specific; May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity); Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (395 aa) |
| | FASN | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. (2515 aa) |
| | ADH5 | Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (374 aa) |
| | GPD1 | Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic. (455 aa) |
| | PYCR3 | Pyrroline-5-carboxylate reductase 3; Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline. (308 aa) |
| | HSD17B3 | Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (310 aa) |
| | MECR | Enoyl-[acyl-carrier-protein] reductase, mitochondrial; Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Has a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). Belongs to the zinc-containing alcohol dehydrogenase family. Quin [...] (388 aa) |
| | ISYNA1 | Inositol-3-phosphate synthase 1; Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1- phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity). (557 aa) |
| | DHRS4 | Dehydrogenase/reductase SDR family member 4; Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha- dicarbonyl compounds with aromatic rings, such as pyrimidine-4- aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4- hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). (279 aa) |
| | HSD17B10 | 3-hydroxyacyl-CoA dehydrogenase type-2; Mitochondrial dehydrogenase that catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha- hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20- beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD). Essential for structura [...] (261 aa) |
| | AHCY | Adenosylhomocysteinase; Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. (432 aa) |
| | DHRS7B | Dehydrogenase/reductase SDR family member 7B; Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (325 aa) |
| | BLVRB | Flavin reductase (NADPH); Broad specificity oxidoreductase that catalyzes the NADPH- dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin. (206 aa) |
| | DHRS11 | Dehydrogenase/reductase SDR family member 11; Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta- hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones. (330 aa) |
| | DHRS1 | Dehydrogenase/reductase (SDR family) member 1. (312 aa) |
| | RDH8 | Retinol dehydrogenase 8; Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa) |
| | CRYM | Ketimine reductase mu-crystallin; Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors (By similarity). (314 aa) |
| | MTHFD1 | Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (935 aa) |
| | MDH2 | Malate dehydrogenase, mitochondrial. (338 aa) |
| | HSD17B14 | 17-beta-hydroxysteroid dehydrogenase 14; Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro) (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (270 aa) |
| | FAR1 | Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (515 aa) |
| | HSD3B1 | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. (382 aa) |
| | KDSR | 3-ketodihydrosphingosine reductase; Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (332 aa) |
| | GLUD1 | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (561 aa) |
| | VAT1 | Vesicle amine transport 1. (402 aa) |
| | ADH6 | Uncharacterized protein. (375 aa) |
| | ADH1C | Uncharacterized protein. (384 aa) |
| | HSD17B4 | Hydroxysteroid (17-beta) dehydrogenase 4. (736 aa) |
| | PECR | Peroxisomal trans-2-enoyl-CoA reductase. (305 aa) |
| | PHGDH | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa) |
| | HSD17B11 | Hydroxysteroid (17-beta) dehydrogenase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (316 aa) |
| | SUCLG1 | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (346 aa) |
| | HSD17B7 | Hydroxysteroid 17-beta dehydrogenase 7. (334 aa) |
| | HSD11B2 | Corticosteroid 11-beta-dehydrogenase isozyme 2; Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. Affinity towards corticosterone is higher than cortisol or dexamethasone; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (373 aa) |
| | ME1 | Malic enzyme. (571 aa) |
| | UXS1 | UDP-glucuronate decarboxylase 1. (420 aa) |
| | NDUFA9 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (380 aa) |
| | RDH14 | Retinol dehydrogenase 14; Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol. Shows a very weak activity towards 13-cis-retinol. Has no activity towards steroid. (336 aa) |
| | DHRS7C | Dehydrogenase/reductase SDR family member 7C; Putative oxidoreductase. (311 aa) |
| | GALE | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversi [...] (503 aa) |
| | MTHFD2 | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency. (378 aa) |
| | DHRS9 | Dehydrogenase/reductase SDR family member 9; 3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha- tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. Plays also a role in the biosynthesis of retinoic acid from retinaldehyde. Can utilize both NADH and NADPH. (319 aa) |
| | SCCPDH | Saccharopine dehydrogenase-like oxidoreductase; Belongs to the saccharopine dehydrogenase family. (429 aa) |
| | PTGR2 | Prostaglandin reductase 2; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity). (351 aa) |
| | STEAP2 | Six transmembrane epithelial antigen of the prostate 2. (490 aa) |
| | TP53I3 | Tumor protein p53 inducible protein 3. (332 aa) |
| | CTBP2 | C-terminal-binding protein 2; Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity). Isoform 2 probably acts as a scaffold for specialized synapses. (982 aa) |
| | HSD17B2 | 17-beta hydroxysteroid dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (388 aa) |
| | ADH4 | PKS_ER domain-containing protein. (380 aa) |
| | BDH2 | 3-hydroxybutyrate dehydrogenase type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron assimilation and homeostasis. Plays a role in susceptibility to bacterial infection by providing an assimilable source of iron that is exploited by pathogenic bacteria (By similarity). Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity). (245 aa) |
| | LDHC | L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa) |
| | HSD3B7 | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7; Belongs to the 3-beta-HSD family. (368 aa) |
| | HADH | Hydroxyacyl-CoA dehydrogenase. (314 aa) |
| | RDH11 | Retinol dehydrogenase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (340 aa) |
| | HSD11B1L | Hydroxysteroid 11-beta-dehydrogenase 1-like protein. (287 aa) |
| | AHCYL2 | Adenosylhomocysteinase 3; May regulate the electrogenic sodium/bicarbonate cotransporter SLC4A4 activity and Mg(2+)-sensitivity. On the contrary of its homolog AHCYL1, does not regulate ITPR1 sensitivity to inositol 1,4,5-trisphosphate (By similarity). (611 aa) |
| | GLYR1 | Putative oxidoreductase GLYR1; Nucleosome-destabilizing factor that is recruited to genes during transcriptional activation. Facilitates Pol II transcription through nucleosomes. Binds DNA (in vitro). Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3). Promotes KDM1B demethylase activity. Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300. Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. [...] (553 aa) |
| | ZADH2 | Prostaglandin reductase-3; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. (382 aa) |
| | RDH16 | Microsomal NAD+-dependent retinol dehydrogenase 4; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa) |
| | HIBADH | 3-hydroxyisobutyrate dehydrogenase, mitochondrial; Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily. (336 aa) |
| | BDH1 | D-beta-hydroxybutyrate dehydrogenase, mitochondrial; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (344 aa) |
| | ME3 | Malic enzyme. (604 aa) |
| | HSD17B12 | Very-long-chain 3-oxoacyl-CoA reductase; Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3- hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membra [...] (312 aa) |
