STRINGSTRING
PNLIPRP3 PNLIPRP3 DENND5A DENND5A LOXHD1 LOXHD1 PNLIPRP1 PNLIPRP1 PKD1L3 PKD1L3 PKDREJ PKDREJ LIPG LIPG G3MZE3_BOVIN G3MZE3_BOVIN PKD1L2 PKD1L2 ALOX12E ALOX12E ALOXE3 ALOXE3 ALOX12 ALOX12 ALOX5 ALOX5 DENND5B DENND5B LPL LPL ALOX12B ALOX12B ALOX15 ALOX15 PNLIPRP2 PNLIPRP2 ALOX15B ALOX15B LOC101904413 LOC101904413 LIPC LIPC PNLIP PNLIP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PNLIPRP3Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (469 aa)
DENND5ADENN domain containing 5A. (1290 aa)
LOXHD1Lipoxygenase homology domains 1. (2278 aa)
PNLIPRP1Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (443 aa)
PKD1L3Polycystin 1 like 3, transient receptor potential channel interacting. (1697 aa)
PKDREJUncharacterized protein. (2243 aa)
LIPGLipase G, endothelial type. (500 aa)
G3MZE3_BOVINUncharacterized protein. (2264 aa)
PKD1L2Uncharacterized protein. (2428 aa)
ALOX12EALOX12E protein. (633 aa)
ALOXE3Arachidonate lipoxygenase 3. (711 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (663 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
DENND5BDENN domain containing 5B. (1274 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries (By similarity). Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. Belongs to the AB hydrolase superfamily. Lipase family. (478 aa)
ALOX12BArachidonate 12-lipoxygenase, 12R type. (699 aa)
ALOX15Arachidonate 15-lipoxygenase; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12- HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the o [...] (663 aa)
PNLIPRP2Pancreatic lipase-related protein 2; Lipase with broad substrate specificity. Can hydrolyze both phospholipids and galactolipids. Acts preferentially on monoglycerides, phospholipids and galactolipids. Contributes to milk fat hydrolysis (By similarity). (469 aa)
ALOX15BArachidonate 15-lipoxygenase type B. (677 aa)
LOC101904413Uncharacterized protein. (2124 aa)
LIPCHepatic triacylglycerol lipase; Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin (By similarity). (500 aa)
PNLIPTriacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (465 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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