STRINGSTRING
SNX2 SNX2 RPS6KC1 RPS6KC1 SNX10 SNX10 SNX1 SNX1 SNX15 SNX15 NCF1 NCF1 SNX20 SNX20 SNX9 SNX9 ARHGAP33 ARHGAP33 SNX31 SNX31 SNX4 SNX4 SNX33 SNX33 SNX6 SNX6 SNX19 SNX19 PIK3C2B PIK3C2B SGK3 SGK3 SNX8 SNX8 NISCH NISCH ARHGAP32 ARHGAP32 SNX22 SNX22 SNX3 SNX3 SNX17 SNX17 SNX16 SNX16 SNX11 SNX11 SNX14 SNX14 SNX27 SNX27 F1ML34_BOVIN F1ML34_BOVIN SNX5 SNX5 SNX18 SNX18 PIK3C2G PIK3C2G PIK3C2A PIK3C2A NOXO1 NOXO1 PXDC1 PXDC1 SNX30 SNX30 SNX24 SNX24 KIF16B KIF16B PXK PXK SNX21 SNX21 ENSBTAP00000060718 ENSBTAP00000060718 SNX13 SNX13 SNX29 SNX29 HS1BP3 HS1BP3 SNX7 SNX7 SH3PXD2B SH3PXD2B ENSBTAP00000067488 ENSBTAP00000067488 PLD1 PLD1 ZCCHC2 ZCCHC2 NCF4 NCF4 SNX12 SNX12 ZCCHC14 ZCCHC14 PLD2 PLD2 SNX25 SNX25
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SNX2Sorting nexin-2; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called en [...] (519 aa)
RPS6KC1Ribosomal protein S6 kinase C1. (1061 aa)
SNX10Sorting nexin-10; Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption (By similarity). (200 aa)
SNX1Sorting nexin-1; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called en [...] (522 aa)
SNX15Sorting nexin-15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN (By similarity). (345 aa)
NCF1Neutrophil cytosol factor 1; NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). (391 aa)
SNX20Sorting nexin-20; May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, or on SELPLG-mediated cell-cell adhesion. (316 aa)
SNX9Sorting nexin. (617 aa)
ARHGAP33Rho GTPase activating protein 33. (1261 aa)
SNX31Sorting nexin 31. (437 aa)
SNX4Sorting nexin-4; Involved in the regulation of endocytosis and in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation. Belongs to the sorting nexin family. (450 aa)
SNX33Sorting nexin. (571 aa)
SNX6Sorting nexin 6. (304 aa)
SNX19Sorting nexin 19. (1000 aa)
PIK3C2BPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1634 aa)
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (490 aa)
SNX8Sorting nexin-8; May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network (By similarity). Belongs to the sorting nexin family. (459 aa)
NISCHNischarin. (1508 aa)
ARHGAP32Rho GTPase activating protein 32. (2096 aa)
SNX22Sorting nexin 22. (173 aa)
SNX3Sorting nexin-3; Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo- selective subcomplex (CSC). May act in part as component of the SNX3- retromer complex which mediates the retrograde [...] (162 aa)
SNX17Sorting nexin-17; Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). (470 aa)
SNX16Sorting nexin 16. (343 aa)
SNX11Sorting nexin-11; Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes; Belongs to the sorting nexin family. (270 aa)
SNX14Sorting nexin 14. (946 aa)
SNX27Sorting nexin-27; Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C- terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing e [...] (554 aa)
F1ML34_BOVINSorting nexin; Involved in several stages of intracellular trafficking. (397 aa)
SNX5Sorting nexin-5; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol lipids. Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Does not have in vitro vesicle-to-me [...] (404 aa)
SNX18Sorting nexin. (626 aa)
PIK3C2GPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family. (1446 aa)
PIK3C2APhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1688 aa)
NOXO1NADPH oxidase organizer 1. (334 aa)
PXDC1PX domain-containing protein 1. (231 aa)
SNX30Sorting nexin family member 30. (437 aa)
SNX24Sorting nexin-24; May be involved in several stages of intracellular trafficking. (182 aa)
KIF16BKinesin family member 16B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1309 aa)
PXKPX domain containing serine/threonine kinase like. (579 aa)
SNX21PX domain-containing protein. (371 aa)
ENSBTAP00000060718PX domain-containing protein. (233 aa)
SNX13Sorting nexin 13. (1151 aa)
SNX29Sorting nexin-29; Belongs to the sorting nexin family. (817 aa)
HS1BP3HCLS1 binding protein 3. (395 aa)
SNX7Sorting nexin 7. (472 aa)
SH3PXD2BSH3 and PX domains 2B. (928 aa)
ENSBTAP00000067488PX domain-containing protein. (232 aa)
PLD1Phospholipase. (1174 aa)
ZCCHC2Zinc finger CCHC-type containing 2. (1115 aa)
NCF4Neutrophil cytosolic factor 4. (338 aa)
SNX12Sorting nexin 12. (164 aa)
ZCCHC14Zinc finger CCHC-type containing 14. (1083 aa)
PLD2Phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis; Belongs to the phospholipase D family. (1088 aa)
SNX25Sorting nexin 25. (944 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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