Your Input: | |
| | MPP6 | Membrane palmitoylated protein 6; Belongs to the MAGUK family. (623 aa) |
| | DOCK5 | Dedicator of cytokinesis 5; Belongs to the DOCK family. (1962 aa) |
| | PACSIN1 | Protein kinase C and casein kinase substrate in neurons protein 1; Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell corte [...] (459 aa) |
| | MIA3 | Transport and Golgi organization protein 1 homolog; Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein s [...] (1929 aa) |
| | DLG1 | Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (906 aa) |
| | DLG3 | Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (849 aa) |
| | PSTPIP1 | Proline-serine-threonine phosphatase interacting protein 1. (496 aa) |
| | SORBS3 | Sorbin and SH3 domain containing 3. (866 aa) |
| | PRMT2 | Protein arginine methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (480 aa) |
| | NEB | Nebulin. (8139 aa) |
| | KALRN-2 | Uncharacterized protein. (1289 aa) |
| | ARHGEF16 | Rho guanine nucleotide exchange factor 16. (708 aa) |
| | ENSBTAP00000065308 | Uncharacterized protein. (1522 aa) |
| | RUSC2 | RUN and SH3 domain containing 2. (1510 aa) |
| | ARHGAP26 | Rho GTPase activating protein 26. (815 aa) |
| | MPP4 | Membrane palmitoylated protein 4; Belongs to the MAGUK family. (611 aa) |
| | SH3D19 | SH3 domain containing 19. (1065 aa) |
| | ARHGAP10 | Rho GTPase-activating protein 10; GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). (810 aa) |
| | SH3PXD2B | SH3 and PX domains 2B. (928 aa) |
| | EPS8L2 | EPS8 like 2. (723 aa) |
| | PPP1R13L | Protein phosphatase 1 regulatory subunit 13 like. (919 aa) |
| | PACSIN2 | Protein kinase C and casein kinase substrate in neurons 2. (486 aa) |
| | RUSC1 | RUN and SH3 domain containing 1. (1042 aa) |
| | CACNB3 | Voltage-dependent L-type calcium channel subunit beta-3; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation. Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). (550 aa) |
| | CASK | Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (935 aa) |
| | MPP5 | Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa) |
| | MATK | Tyrosine-protein kinase. (485 aa) |
| | HCK | Tyrosine-protein kinase. (558 aa) |
| | MIA2 | SH3 domain-containing protein. (1381 aa) |
| | DLG5 | Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1946 aa) |
| | ENSBTAP00000060212 | SH3 domain-containing protein. (219 aa) |
| | SH3TC1 | SH3 domain and tetratricopeptide repeats 1. (1290 aa) |
| | DOCK2 | Dedicator of cytokinesis 2; Belongs to the DOCK family. (1868 aa) |
| | DLG2 | Discs large MAGUK scaffold protein 2. (905 aa) |
| | PPP1R13B | Protein phosphatase 1 regulatory subunit 13B. (1131 aa) |
| | EPS8L1 | EPS8 like 1. (769 aa) |
| | SH3GLB2 | Endophilin-B2; Belongs to the endophilin family. (450 aa) |
| | ARHGEF4 | Rho guanine nucleotide exchange factor 4. (773 aa) |
| | EFS | Embryonal Fyn-associated substrate. (574 aa) |
| | ABL1 | Tyrosine-protein kinase. (1151 aa) |
| | SORBS2 | Uncharacterized protein. (760 aa) |
| | SPTAN1 | Spectrin alpha, non-erythrocytic 1. (2489 aa) |
| | NCF2 | Neutrophil cytosol factor 2; NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production); Belongs to the NCF2/NOXA1 family. (527 aa) |
| | SRGAP2 | Uncharacterized protein. (1071 aa) |
| | SHANK2 | SH3 and multiple ankyrin repeat domains 2. (1887 aa) |
| | ARHGAP42 | Rho GTPase activating protein 42. (874 aa) |
| | TJP3 | Tight junction protein 3; Belongs to the MAGUK family. (922 aa) |
| | BLK | Tyrosine-protein kinase. (524 aa) |
| | MYO7A | Myosin VIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2202 aa) |
| | FNBP1 | Formin binding protein 1. (668 aa) |
| | ASAP1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1; Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. Plays a role in ciliogenesis (By similarity). May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. (1176 aa) |
| | ARHGAP4 | Rho GTPase activating protein 4. (951 aa) |
| | NEDD9 | Neural precursor cell expressed, developmentally down-regulated 9. (830 aa) |
| | CRKL | CRK like proto-oncogene, adaptor protein. (302 aa) |
| | RIMBP3B | Uncharacterized protein. (1601 aa) |
| | SH3PXD2A | SH3 and PX domains 2A. (936 aa) |
| | NEBL | Nebulette. (1013 aa) |
| | PTK6 | Tyrosine-protein kinase. (450 aa) |
| | MYO1E | Myosin IE; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1108 aa) |
| | MYO7B | Myosin VIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2140 aa) |
| | TRIO | Trio Rho guanine nucleotide exchange factor. (3028 aa) |
| | SPTA1 | Spectrin alpha, erythrocytic 1. (2411 aa) |
| | SH3RF3 | SH3 domain containing ring finger 3. (844 aa) |
| | SH3D21 | SH3 domain containing 21. (676 aa) |
| | VAV1 | Proto-oncogene vav; Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. (844 aa) |
| | CASKIN1 | CASK interacting protein 1. (1361 aa) |
| | SHANK1 | SH3 and multiple ankyrin repeat domains 1. (2147 aa) |
| | MAP3K10 | Mitogen-activated protein kinase kinase kinase. (948 aa) |
| | NOXO1 | NADPH oxidase organizer 1. (334 aa) |
| | TEC | Tyrosine-protein kinase. (445 aa) |
| | SKAP2 | Src kinase-associated phosphoprotein 2; May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway (By similarity). Belongs to the SKAP family. (358 aa) |
| | PRAM1 | PML-RARA regulated adaptor molecule 1. (682 aa) |
| | GRAP | GRB2-related adapter protein; Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. Plays a role in the inner ear and in hearing. (217 aa) |
| | LASP1 | LIM and SH3 domain protein 1; Plays an important role in the regulation of dynamic actin- based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). (260 aa) |
| | G3X7Q0_BOVIN | SH3 domain-containing protein. (249 aa) |
| | BAIAP2 | Brain-specific angiogenesis inhibitor 1-associated protein 2; Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling whe [...] (535 aa) |
| | SNX18 | Sorting nexin. (626 aa) |
| | TJP1 | Tight junction protein 1; Belongs to the MAGUK family. (1429 aa) |
| | LCK | Tyrosine-protein kinase. (509 aa) |
| | MPP7 | MAGUK p55 subfamily member 7; Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact (By similarity). (576 aa) |
| | ITK | Tyrosine-protein kinase. (620 aa) |
| | MPP2 | Membrane palmitoylated protein 2; Belongs to the MAGUK family. (552 aa) |
| | MACF1 | Microtubule actin crosslinking factor 1. (7311 aa) |
| | DOCK1 | Dedicator of cytokinesis 1; Belongs to the DOCK family. (1867 aa) |
| | BAIAP2L1 | BAI1 associated protein 2 like 1. (511 aa) |
| | SH3YL1 | SH3 domain-containing YSC84-like protein 1. (341 aa) |
| | BTK | Tyrosine-protein kinase. (659 aa) |
| | ITSN2 | Intersectin 2. (1024 aa) |
| | ITSN1 | Intersectin 1. (1716 aa) |
| | NCKIPSD | NCK interacting protein with SH3 domain. (720 aa) |
| | TNK2 | Activated CDC42 kinase 1; Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting [...] (1111 aa) |
| | UBASH3A | Ubiquitin associated and SH3 domain containing A. (592 aa) |
| | MAP3K21 | Mitogen-activated protein kinase kinase kinase. (1047 aa) |
| | ARHGEF7 | Rho guanine nucleotide exchange factor 7. (862 aa) |
| | LYN | Tyrosine-protein kinase. (512 aa) |
| | FRK | Tyrosine-protein kinase. (514 aa) |
| | FUT8 | Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family. (575 aa) |
| | SLA2 | Src-like-adaptor 2 isoform a. (276 aa) |
| | SPATA13 | Uncharacterized protein. (1208 aa) |
| | FCHSD2 | FCH and double SH3 domains 2. (764 aa) |
| | NCK1 | Cytoplasmic protein. (377 aa) |
| | ARHGAP9 | Rho GTPase activating protein 9. (762 aa) |
| | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] (724 aa) |
| | FYN | Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] (537 aa) |
| | SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1. (1085 aa) |
| | SNX33 | Sorting nexin. (571 aa) |
| | ARHGEF26 | Rho guanine nucleotide exchange factor 26. (870 aa) |
| | STAC3 | SH3 and cysteine rich domain 3. (362 aa) |
| | SH3GL3 | SH3 domain containing GRB2 like 3, endophilin A3. (347 aa) |
| | ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor 6. (800 aa) |
| | TNK1 | Tyrosine kinase non receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (667 aa) |
| | SHANK3 | SH3 and multiple ankyrin repeat domains 3. (1807 aa) |
| | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity). (1291 aa) |
| | DBNL | Drebrin-like protein; Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that reg [...] (428 aa) |
| | MPP3 | Membrane palmitoylated protein 3; Belongs to the MAGUK family. (585 aa) |
| | SH3TC2 | SH3 domain and tetratricopeptide repeats 2. (1360 aa) |
| | MAPK8IP2 | Mitogen-activated protein kinase 8 interacting protein 2. (821 aa) |
| | FCHSD1 | Uncharacterized protein. (692 aa) |
| | ARHGAP32 | Rho GTPase activating protein 32. (2096 aa) |
| | VAV3 | Vav guanine nucleotide exchange factor 3. (845 aa) |
| | ARHGEF37 | Rho guanine nucleotide exchange factor 37. (670 aa) |
| | BAIAP2L2 | Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2; Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity). (528 aa) |
| | GRAP2 | GRB2 related adaptor protein 2. (316 aa) |
| | DSP | Desmoplakin. (2889 aa) |
| | ABL2 | Tyrosine-protein kinase. (1182 aa) |
| | CASS4 | Cas scaffold protein family member 4. (811 aa) |
| | SH3GL2 | SH3 domain containing GRB2 like 2, endophilin A1. (352 aa) |
| | SH3BP4 | SH3 domain binding protein 4. (963 aa) |
| | TRIP10 | Thyroid hormone receptor interactor 10. (603 aa) |
| | MAPK8IP1 | Mitogen-activated protein kinase 8 interacting protein 1. (710 aa) |
| | EPS8 | Epidermal growth factor receptor pathway substrate 8. (838 aa) |
| | OTOR | Otoraplin. (129 aa) |
| | SKAP1 | Src kinase associated phosphoprotein 1. (370 aa) |
| | UBASH3B | Ubiquitin associated and SH3 domain containing B. (649 aa) |
| | HCLS1 | Hematopoietic cell-specific Lyn substrate 1. (485 aa) |
| | FYB1 | FYN binding protein 1. (827 aa) |
| | SH3RF1 | E3 ubiquitin-protein ligase SH3RF1; Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin- dependent and clathrin-independent endocytosis. Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pa [...] (840 aa) |
| | YES1 | Tyrosine-protein kinase. (541 aa) |
| | ARHGEF5 | Rho guanine nucleotide exchange factor 5. (1584 aa) |
| | SASH1 | SAM and SH3 domain containing 1. (1236 aa) |
| | EPS8L3 | EPS8 like 3. (591 aa) |
| | STAM2 | Uncharacterized protein. (526 aa) |
| | SRMS | Tyrosine-protein kinase. (494 aa) |
| | CACNB1 | Voltage-dependent L-type calcium channel subunit beta-1; Regulatory subunit of L-type calcium channels. Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore- forming subunit and increases the presence of the channel complex at the cell membrane. Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming [...] (643 aa) |
| | SASH3 | SAM and SH3 domain-containing protein 3; May function as a signaling adapter protein in lymphocytes. (380 aa) |
| | CACNB4 | Calcium voltage-gated channel auxiliary subunit beta 4. (520 aa) |
| | ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2. (1008 aa) |
| | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta; Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein- tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating t [...] (724 aa) |
| | DLG4 | Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (721 aa) |
| | SAMSN1 | SAM domain, SH3 domain and nuclear localization signals 1. (366 aa) |
| | STAM | Signal transducing adaptor molecule. (534 aa) |
| | OSTF1 | Osteoclast-stimulating factor 1; Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity. (214 aa) |
| | NCF1 | Neutrophil cytosol factor 1; NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). (391 aa) |
| | MAP3K11 | Mitogen-activated protein kinase kinase kinase. (864 aa) |
| | FNBP1L | Formin binding protein 1 like. (558 aa) |
| | SRGAP3 | SLIT-ROBO Rho GTPase activating protein 3. (1099 aa) |
| | GRB2 | Growth factor receptor-bound protein 2. (217 aa) |
| | PEX13 | Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins (By similarity). (403 aa) |
| | CRK | CRK proto-oncogene, adaptor protein. (304 aa) |
| | ARHGEF19 | Rho guanine nucleotide exchange factor 19. (807 aa) |
| | SH3GL1 | Endophilin-A2; Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). Belongs to the endophilin family. (368 aa) |
| | CTTN | Cortactin. (538 aa) |
| | SNX9 | Sorting nexin. (617 aa) |
| | ZDHHC6 | Palmitoyltransferase ZDHHC6; Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC. Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins. Mediates palmitoylation of AMFR, promoting AMFR distribution to the peripheral endoplasmic reticulum. Together with SELENOK, palmitoylates ITPR1 in immune cells, leading to regulate ITPR1 stability and function. (413 aa) |
| | STAC | SH3 and cysteine-rich domain-containing protein; Promotes expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity. Plays a minor and redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C. (403 aa) |
| | SH3RF2 | SH3 domain containing ring finger 2. (728 aa) |
| | CASKIN2 | CASK interacting protein 2. (1173 aa) |
| | MYO1F | Myosin IF; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1098 aa) |
| | NPHP1 | Nephrocystin 1. (686 aa) |
| | STAC2 | SH3 and cysteine rich domain 2. (408 aa) |
| | ARHGEF38 | Rho guanine nucleotide exchange factor 38. (781 aa) |
| | SRC | Tyrosine-protein kinase. (688 aa) |
| | DNMBP | Dynamin binding protein. (1579 aa) |
| | NGEF | Neuronal guanine nucleotide exchange factor. (616 aa) |
| | MIA | Melanoma-derived growth regulatory protein; May function during cartilage development and maintenance; Belongs to the MIA/OTOR family. (130 aa) |
| | FYB2 | FYN binding protein 2. (756 aa) |
| | RASA1 | Ras GTPase-activating protein 1; Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21. (1044 aa) |
| | PACSIN3 | Protein kinase C and casein kinase substrate in neurons 3. (421 aa) |
| | SGSM3 | Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells. (747 aa) |
| | ARHGAP33 | Rho GTPase activating protein 33. (1261 aa) |
| | DOCK4 | Dedicator of cytokinesis 4; Belongs to the DOCK family. (1973 aa) |
| | DST-2 | Uncharacterized protein. (3017 aa) |
| | VAV2 | Vav guanine nucleotide exchange factor 2. (839 aa) |
| | ABI1 | Abl interactor 1. (481 aa) |
| | SLA | Src like adaptor. (308 aa) |
| | SORBS1 | Sorbin and SH3 domain containing 1. (922 aa) |
| | BCAR1 | BCAR1 scaffold protein, Cas family member. (919 aa) |
| | AHI1 | Abelson helper integration site 1. (1172 aa) |
| | CSK | Tyrosine-protein kinase CSK; Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C- terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins [...] (450 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1264 aa) |
| | TJP2 | Tight junction protein 2; Belongs to the MAGUK family. (1178 aa) |
| | CD2AP | CD2 associated protein. (766 aa) |
| | NCK2 | Cytoplasmic protein. (376 aa) |
| | AMPH | Amphiphysin. (853 aa) |
| | NCF4 | Neutrophil cytosolic factor 4. (338 aa) |
| | MPP1 | 55 kDa erythrocyte membrane protein; Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity). Belongs to the MAGUK family. (503 aa) |
| | ARHGEF9 | Rho guanine nucleotide exchange factor 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters (By similarity). (1103 aa) |
| | MAP3K9 | Mitogen-activated protein kinase kinase kinase. (1103 aa) |
| | SH3KBP1 | SH3 domain containing kinase binding protein 1. (665 aa) |
| | BIN1 | Bridging integrator 1. (706 aa) |
| | FGR | Tyrosine-protein kinase. (527 aa) |
| | TP53BP2 | Tumor protein p53 binding protein 2. (1108 aa) |
| | CACNB2 | Voltage-dependent L-type calcium channel subunit beta-2; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. (614 aa) |
| | SH3GLB1 | Endophilin-B1; May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation. Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2). Associated with PI3KC3-C2 d [...] (366 aa) |
| | ARHGAP12 | Rho GTPase activating protein 12. (840 aa) |
| | NOSTRIN | Nostrin; Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane. (506 aa) |
| | TXK | Tyrosine-protein kinase. (527 aa) |
| | ABI3 | ABI family member 3. (364 aa) |
| | GAS7 | Growth arrest specific 7. (476 aa) |
| | RIMBP2 | RIMS binding protein 2. (1436 aa) |
