STRINGSTRING
G8JKV3_BOVIN G8JKV3_BOVIN GLRX3 GLRX3 E1BKQ7_BOVIN E1BKQ7_BOVIN ENSBTAP00000057322 ENSBTAP00000057322 SH3BGRL2 SH3BGRL2 GRXCR1 GRXCR1 GLRX2 GLRX2 GLRX GLRX TXNRD3 TXNRD3 ENSBTAP00000074273 ENSBTAP00000074273 ENSBTAP00000072903 ENSBTAP00000072903 GLRX5 GLRX5 SH3BGR SH3BGR E1B773_BOVIN E1B773_BOVIN SH3BGRL3 SH3BGRL3 F1MIJ5_BOVIN F1MIJ5_BOVIN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
G8JKV3_BOVINGlutaredoxin domain-containing protein. (106 aa)
GLRX3Glutaredoxin-3; Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (By similarity). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity (By similarity). (334 aa)
E1BKQ7_BOVINGlutaredoxin domain-containing protein. (91 aa)
ENSBTAP00000057322Glutaredoxin domain-containing protein. (85 aa)
SH3BGRL2SH3 domain-binding glutamic acid-rich-like protein 2. (135 aa)
GRXCR1Glutaredoxin and cysteine rich domain containing 1. (290 aa)
GLRX2Glutaredoxin-2, mitochondrial; Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylat [...] (157 aa)
GLRXGlutaredoxin-1; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins; Belongs to the glutaredoxin family. (106 aa)
TXNRD3Thioredoxin reductase 3. (596 aa)
ENSBTAP00000074273Glutaredoxin domain-containing protein. (125 aa)
ENSBTAP00000072903Glutaredoxin domain-containing protein. (116 aa)
GLRX5Glutaredoxin 5. (158 aa)
SH3BGRSH3 domain binding glutamate rich protein. (208 aa)
E1B773_BOVINGlutaredoxin domain-containing protein. (106 aa)
SH3BGRL3SH3 domain-binding glutamic acid-rich-like protein 3; Could act as a modulator of glutaredoxin biological activity. Belongs to the SH3BGR family. (93 aa)
F1MIJ5_BOVINGlutaredoxin domain-containing protein. (106 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.