STRINGSTRING
TGFB2 TGFB2 INHBB INHBB MSTN MSTN TGFB3 TGFB3 BMP5 BMP5 BMP3 BMP3 BMP8A BMP8A BMP6 BMP6 GDF6 GDF6 LEFTY2 LEFTY2 GDF7 GDF7 BMP7 BMP7 BMP8B BMP8B INHBA INHBA BMP2 BMP2 GDF11 GDF11 GDF2 GDF2 GDF5 GDF5 BMP4 BMP4 LOC100336971 LOC100336971 BMP10 BMP10 TGFB1 TGFB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (442 aa)
INHBBInhibin beta B chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (408 aa)
MSTNGrowth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth. (375 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
BMP3Bone morphogenetic protein 3; Induces cartilage and bone formation. (475 aa)
BMP8ATGF_BETA_2 domain-containing protein. (405 aa)
BMP6Bone morphogenetic protein 6. (496 aa)
GDF6Growth/differentiation factor 6; Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal- ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-speci [...] (470 aa)
LEFTY2Left-right determination factor. (367 aa)
GDF7Growth differentiation factor 7. (450 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
BMP8BTGF_BETA_2 domain-containing protein. (405 aa)
INHBAInhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (425 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
GDF11Growth differentiation factor 11. (406 aa)
GDF2Growth differentiation factor 2. (431 aa)
GDF5Growth differentiation factor 5. (499 aa)
BMP4Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
LOC100336971Left-right determination factor. (367 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (499 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.