STRINGSTRING
SHH SHH GLI3 GLI3 FGF4 FGF4 EVX1 EVX1 ALB ALB TULP3 TULP3 PAX7 PAX7 MSX2 MSX2 SMO SMO FOXA2 FOXA2 EN1 EN1 GLI2 GLI2 MSX1 MSX1 IHH IHH DBX2 DBX2 ARL13B ARL13B C2CD3-2 C2CD3-2 PTCH1 PTCH1 IRX3 IRX3 OLIG2 OLIG2 PAX6 PAX6 ISL1 ISL1 DBX1 DBX1 EVC EVC HOXD13 HOXD13 SUFU SUFU C2CD3 C2CD3 IFT88 IFT88 LHX3 LHX3 HOXD11 HOXD11 IFT122 IFT122 KIF3A KIF3A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
GLI3GLI family zinc finger 3. (1587 aa)
FGF4Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis (By similarity). (206 aa)
EVX1Even-skipped homeobox 1. (404 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (Probable). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The sh [...] (607 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (478 aa)
PAX7Paired box 7. (505 aa)
MSX2Homeobox protein MSX-2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity). (267 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
FOXA2Forkhead box A2. (461 aa)
EN1Homeobox protein engrailed-like. (400 aa)
GLI2GLI family zinc finger 2. (1431 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (412 aa)
DBX2Homeobox protein DBX2. (340 aa)
ARL13BADP ribosylation factor like GTPase 13B. (429 aa)
C2CD3-2C2 domain containing 3 centriole elongation regulator. (1587 aa)
PTCH1SSD domain-containing protein. (1453 aa)
IRX3Iroquois homeobox 3. (502 aa)
OLIG2Oligodendrocyte transcription factor 2. (327 aa)
PAX6Paired box protein Pax-6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity); Belongs to the paired homeobox family. (436 aa)
ISL1ISL LIM homeobox 1. (349 aa)
DBX1Homeobox protein DBX1; Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity); Belongs to the H2.0 homeobox family. (345 aa)
EVCEvC ciliary complex subunit 1. (993 aa)
HOXD13Homeobox D13. (341 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
C2CD3Uncharacterized protein. (364 aa)
IFT88Intraflagellar transport 88. (850 aa)
LHX3LIM homeodomain 3 protein b isoform. (403 aa)
HOXD11Homeobox D11. (337 aa)
IFT122Intraflagellar transport 122. (1182 aa)
KIF3AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (702 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
Server load: low (12%) [HD]