STRINGSTRING
ENSBTAP00000071522 ENSBTAP00000071522 SLC35A2 SLC35A2 LOC615303 LOC615303 NR1I3 NR1I3 IL6 IL6 UGT2B10 UGT2B10 ALB ALB RXRA RXRA NR1I2 NR1I2 STAT3 STAT3 LOC100138004 LOC100138004 LOC781988 LOC781988 UGT1A1 UGT1A1 MGC152010 MGC152010 UGT2A1 UGT2A1 CYP2B6 CYP2B6 ENSBTAP00000060742 ENSBTAP00000060742 APP APP LOC100296421 LOC100296421 LOC100138908 LOC100138908 GAPDH GAPDH INS INS LOC530553 LOC530553 LOC540544 LOC540544
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSBTAP00000071522UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (494 aa)
SLC35A2UDP-galactose translocator; Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function. (396 aa)
LOC615303UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (528 aa)
NR1I3Nuclear receptor subfamily 1 group I member 3. (406 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (208 aa)
UGT2B10UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (Probable). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The sh [...] (607 aa)
RXRARetinoid X receptor alpha. (467 aa)
NR1I2Nuclear receptor subfamily 1 group I member 2. (420 aa)
STAT3Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] (770 aa)
LOC100138004UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (531 aa)
LOC781988UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
UGT1A1UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (533 aa)
MGC152010UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
UGT2A1UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa)
CYP2B6Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
ENSBTAP00000060742UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (486 aa)
APPGamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (770 aa)
LOC100296421UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
LOC100138908UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (532 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (376 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
LOC530553UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
LOC540544UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (533 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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