STRINGSTRING
VWF VWF GLI2 GLI2 PLEK PLEK RSPH9 RSPH9 NME5 NME5 PTPDC1 PTPDC1 ARL13B ARL13B TUB TUB IQUB IQUB ARL3 ARL3 PMEL PMEL RPL19 RPL19 MCHR1 MCHR1 LAMP1 LAMP1 TFRC TFRC NME7 NME7 SSTR3 SSTR3 SMO SMO PLK1 PLK1 ENKUR ENKUR TULP3 TULP3 SSNA1 SSNA1 RAB1B RAB1B EEA1 EEA1 IFT88 IFT88 PLEK2 PLEK2 ALB ALB DYNC2H1 DYNC2H1 GLI3 GLI3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VWFVon Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. (2811 aa)
GLI2GLI family zinc finger 2. (1431 aa)
PLEKPleckstrin. (350 aa)
RSPH9Radial spoke head protein 9 homolog; Probable component of the axonemal radial spoke head (By similarity). Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk, which is attached to a subfiber of the outer doublet microtubule, and a bulbous head, which is attached to the stalk and appears to interact with the projections from the central pair of microtubules. (276 aa)
NME5NME/NM23 family member 5; Belongs to the NDK family. (209 aa)
PTPDC1Protein tyrosine phosphatase domain-containing protein 1; May play roles in cilia formation and/or maintenance. (825 aa)
ARL13BADP ribosylation factor like GTPase 13B. (429 aa)
TUBTubby-like protein; Belongs to the TUB family. (524 aa)
IQUBIQ motif and ubiquitin domain containing. (795 aa)
ARL3ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliar [...] (198 aa)
PMELMelanocyte protein PMEL; Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures (By similarity). (649 aa)
RPL1960S ribosomal protein L19. (196 aa)
MCHR1Melanin concentrating hormone receptor 1. (353 aa)
LAMP1Lysosome-associated membrane glycoprotein 1; Belongs to the LAMP family. (409 aa)
TFRCTransferrin receptor. (769 aa)
NME7Nucleoside diphosphate kinase 7; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity); Belongs to the NDK family. (377 aa)
SSTR3Somatostatin receptor 3; Belongs to the G-protein coupled receptor 1 family. (422 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
PLK1Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase- promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, C [...] (602 aa)
ENKUREnkurin, TRPC channel interacting protein. (259 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (478 aa)
SSNA1Sjoegren syndrome nuclear autoantigen 1 homolog. (119 aa)
RAB1BRas-related protein Rab-1B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (By similarity). Regulates [...] (296 aa)
EEA1Early endosome antigen 1. (1452 aa)
IFT88Intraflagellar transport 88. (850 aa)
PLEK2Pleckstrin 2. (354 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (Probable). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The sh [...] (607 aa)
DYNC2H1Uncharacterized protein. (1257 aa)
GLI3GLI family zinc finger 3. (1587 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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