node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARL13B | IFT88 | ENSBTAP00000006796 | ENSBTAP00000073403 | ADP ribosylation factor like GTPase 13B. | Intraflagellar transport 88. | 0.951 |
ARL13B | OFD1 | ENSBTAP00000006796 | ENSBTAP00000058377 | ADP ribosylation factor like GTPase 13B. | LisH domain-containing protein. | 0.687 |
ARL13B | PKD2 | ENSBTAP00000006796 | ENSBTAP00000063046 | ADP ribosylation factor like GTPase 13B. | Polycystin-2; Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Can also form a functional, homotetrameric ion channel (By similarity). Functions as a cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Functions as outward-rectifying K(+) channel, but is also permeable to Ca(2+), and to a much lesser degree also to Na(+) (By similarity). May contribute to the release of Ca(2+) stores from the endoplasmic reticulum [...] | 0.801 |
ARL13B | RAB23 | ENSBTAP00000006796 | ENSBTAP00000007050 | ADP ribosylation factor like GTPase 13B. | RAB23, member RAS oncogene family. | 0.661 |
ARL13B | RAB8A | ENSBTAP00000006796 | ENSBTAP00000021408 | ADP ribosylation factor like GTPase 13B. | Ras-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...] | 0.715 |
ARL13B | RHO | ENSBTAP00000006796 | ENSBTAP00000001730 | ADP ribosylation factor like GTPase 13B. | Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G- proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling. | 0.642 |
ARL13B | SMO | ENSBTAP00000006796 | ENSBTAP00000017670 | ADP ribosylation factor like GTPase 13B. | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.892 |
CTNNB1 | PTI | ENSBTAP00000021838 | ENSBTAP00000056883 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | Pancreatic trypsin inhibitor; Inhibits trypsin, kallikrein, chymotrypsin, and plasmin. | 0.719 |
CTNNB1 | RHO | ENSBTAP00000021838 | ENSBTAP00000001730 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G- proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling. | 0.435 |
CTNNB1 | SMO | ENSBTAP00000021838 | ENSBTAP00000017670 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.627 |
IFT88 | ARL13B | ENSBTAP00000073403 | ENSBTAP00000006796 | Intraflagellar transport 88. | ADP ribosylation factor like GTPase 13B. | 0.951 |
IFT88 | OFD1 | ENSBTAP00000073403 | ENSBTAP00000058377 | Intraflagellar transport 88. | LisH domain-containing protein. | 0.680 |
IFT88 | PKD2 | ENSBTAP00000073403 | ENSBTAP00000063046 | Intraflagellar transport 88. | Polycystin-2; Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Can also form a functional, homotetrameric ion channel (By similarity). Functions as a cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Functions as outward-rectifying K(+) channel, but is also permeable to Ca(2+), and to a much lesser degree also to Na(+) (By similarity). May contribute to the release of Ca(2+) stores from the endoplasmic reticulum [...] | 0.725 |
IFT88 | RAB23 | ENSBTAP00000073403 | ENSBTAP00000007050 | Intraflagellar transport 88. | RAB23, member RAS oncogene family. | 0.426 |
IFT88 | RAB8A | ENSBTAP00000073403 | ENSBTAP00000021408 | Intraflagellar transport 88. | Ras-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...] | 0.494 |
IFT88 | RHO | ENSBTAP00000073403 | ENSBTAP00000001730 | Intraflagellar transport 88. | Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G- proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling. | 0.433 |
IFT88 | SMO | ENSBTAP00000073403 | ENSBTAP00000017670 | Intraflagellar transport 88. | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.849 |
OFD1 | ARL13B | ENSBTAP00000058377 | ENSBTAP00000006796 | LisH domain-containing protein. | ADP ribosylation factor like GTPase 13B. | 0.687 |
OFD1 | IFT88 | ENSBTAP00000058377 | ENSBTAP00000073403 | LisH domain-containing protein. | Intraflagellar transport 88. | 0.680 |
OFD1 | PKD2 | ENSBTAP00000058377 | ENSBTAP00000063046 | LisH domain-containing protein. | Polycystin-2; Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Can also form a functional, homotetrameric ion channel (By similarity). Functions as a cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Functions as outward-rectifying K(+) channel, but is also permeable to Ca(2+), and to a much lesser degree also to Na(+) (By similarity). May contribute to the release of Ca(2+) stores from the endoplasmic reticulum [...] | 0.406 |