node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARL3 | IFT88 | ENSBTAP00000005655 | ENSBTAP00000073403 | ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliar [...] | Intraflagellar transport 88. | 0.727 |
ARL3 | KIF17 | ENSBTAP00000005655 | ENSBTAP00000071320 | ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliar [...] | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.520 |
ARL3 | KIF17-2 | ENSBTAP00000005655 | ENSBTAP00000048080 | ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliar [...] | Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.520 |
ARL3 | RAB23 | ENSBTAP00000005655 | ENSBTAP00000007050 | ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliar [...] | RAB23, member RAS oncogene family. | 0.631 |
ARL3 | SMO | ENSBTAP00000005655 | ENSBTAP00000017670 | ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliar [...] | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.423 |
ARL3 | SSTR3 | ENSBTAP00000005655 | ENSBTAP00000053989 | ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliar [...] | Somatostatin receptor 3; Belongs to the G-protein coupled receptor 1 family. | 0.576 |
GLI2 | GLI3 | ENSBTAP00000015510 | ENSBTAP00000033519 | GLI family zinc finger 2. | GLI family zinc finger 3. | 0.923 |
GLI2 | IFT88 | ENSBTAP00000015510 | ENSBTAP00000073403 | GLI family zinc finger 2. | Intraflagellar transport 88. | 0.819 |
GLI2 | PTCH1 | ENSBTAP00000015510 | ENSBTAP00000055675 | GLI family zinc finger 2. | SSD domain-containing protein. | 0.928 |
GLI2 | RAB23 | ENSBTAP00000015510 | ENSBTAP00000007050 | GLI family zinc finger 2. | RAB23, member RAS oncogene family. | 0.646 |
GLI2 | SHH | ENSBTAP00000015510 | ENSBTAP00000034059 | GLI family zinc finger 2. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.905 |
GLI2 | SMO | ENSBTAP00000015510 | ENSBTAP00000017670 | GLI family zinc finger 2. | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.961 |
GLI2 | SUFU | ENSBTAP00000015510 | ENSBTAP00000069136 | GLI family zinc finger 2. | Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] | 0.998 |
GLI3 | GLI2 | ENSBTAP00000033519 | ENSBTAP00000015510 | GLI family zinc finger 3. | GLI family zinc finger 2. | 0.923 |
GLI3 | IFT88 | ENSBTAP00000033519 | ENSBTAP00000073403 | GLI family zinc finger 3. | Intraflagellar transport 88. | 0.886 |
GLI3 | PTCH1 | ENSBTAP00000033519 | ENSBTAP00000055675 | GLI family zinc finger 3. | SSD domain-containing protein. | 0.929 |
GLI3 | RAB23 | ENSBTAP00000033519 | ENSBTAP00000007050 | GLI family zinc finger 3. | RAB23, member RAS oncogene family. | 0.523 |
GLI3 | SHH | ENSBTAP00000033519 | ENSBTAP00000034059 | GLI family zinc finger 3. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.899 |
GLI3 | SMO | ENSBTAP00000033519 | ENSBTAP00000017670 | GLI family zinc finger 3. | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.959 |
GLI3 | SUFU | ENSBTAP00000033519 | ENSBTAP00000069136 | GLI family zinc finger 3. | Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] | 0.997 |