node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALB | ARL13B | ENSBTAP00000022763 | ENSBTAP00000006796 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (Probable). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The sh [...] | ADP ribosylation factor like GTPase 13B. | 0.534 |
ALB | GLI2 | ENSBTAP00000022763 | ENSBTAP00000015510 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (Probable). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The sh [...] | GLI family zinc finger 2. | 0.412 |
ALB | IFT88 | ENSBTAP00000022763 | ENSBTAP00000073403 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (Probable). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The sh [...] | Intraflagellar transport 88. | 0.404 |
ALB | NR3C1 | ENSBTAP00000022763 | ENSBTAP00000069782 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (Probable). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The sh [...] | Nuclear receptor subfamily 3 group C member 1. | 0.595 |
ALB | SHH | ENSBTAP00000022763 | ENSBTAP00000034059 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (Probable). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The sh [...] | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.687 |
ALB | SMO | ENSBTAP00000022763 | ENSBTAP00000017670 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (Probable). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The sh [...] | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.588 |
ARL13B | ALB | ENSBTAP00000006796 | ENSBTAP00000022763 | ADP ribosylation factor like GTPase 13B. | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (Probable). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The sh [...] | 0.534 |
ARL13B | GLI2 | ENSBTAP00000006796 | ENSBTAP00000015510 | ADP ribosylation factor like GTPase 13B. | GLI family zinc finger 2. | 0.716 |
ARL13B | GPR161 | ENSBTAP00000006796 | ENSBTAP00000071010 | ADP ribosylation factor like GTPase 13B. | G protein-coupled receptor 161; Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signalin [...] | 0.848 |
ARL13B | IFT20 | ENSBTAP00000006796 | ENSBTAP00000010668 | ADP ribosylation factor like GTPase 13B. | Intraflagellar transport protein 20 homolog; Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Required for protein stability of E3 ubiquitin ligases CBL and CBLB that mediate ubiquitination and internalization of PDGFRA for proper feedback inhibition of PDGFRA signaling. Essential for male fertility. Plays an important role in spermatogenesis, particularly sperm [...] | 0.849 |
ARL13B | IFT88 | ENSBTAP00000006796 | ENSBTAP00000073403 | ADP ribosylation factor like GTPase 13B. | Intraflagellar transport 88. | 0.951 |
ARL13B | KIF17 | ENSBTAP00000006796 | ENSBTAP00000071320 | ADP ribosylation factor like GTPase 13B. | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.672 |
ARL13B | KIF17-2 | ENSBTAP00000006796 | ENSBTAP00000048080 | ADP ribosylation factor like GTPase 13B. | Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.672 |
ARL13B | SHH | ENSBTAP00000006796 | ENSBTAP00000034059 | ADP ribosylation factor like GTPase 13B. | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. | 0.793 |
ARL13B | SMO | ENSBTAP00000006796 | ENSBTAP00000017670 | ADP ribosylation factor like GTPase 13B. | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.892 |
ARL13B | SSTR3 | ENSBTAP00000006796 | ENSBTAP00000053989 | ADP ribosylation factor like GTPase 13B. | Somatostatin receptor 3; Belongs to the G-protein coupled receptor 1 family. | 0.781 |
GLI2 | ALB | ENSBTAP00000015510 | ENSBTAP00000022763 | GLI family zinc finger 2. | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (Probable). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The sh [...] | 0.412 |
GLI2 | ARL13B | ENSBTAP00000015510 | ENSBTAP00000006796 | GLI family zinc finger 2. | ADP ribosylation factor like GTPase 13B. | 0.716 |
GLI2 | GPR161 | ENSBTAP00000015510 | ENSBTAP00000071010 | GLI family zinc finger 2. | G protein-coupled receptor 161; Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signalin [...] | 0.616 |
GLI2 | IFT88 | ENSBTAP00000015510 | ENSBTAP00000073403 | GLI family zinc finger 2. | Intraflagellar transport 88. | 0.819 |