STRINGSTRING
SMO SMO CD19 CD19 PTEN PTEN GLI2 GLI2 NOTCH1 NOTCH1 CD5 CD5 MTOR MTOR HHIP HHIP ANXA5 ANXA5 GLI3 GLI3 PDGFRA PDGFRA SUFU SUFU FCGR3A FCGR3A EGFR EGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
CD19CD19 molecule. (568 aa)
PTENPhosphatase and tensin homolog. (573 aa)
GLI2GLI family zinc finger 2. (1431 aa)
NOTCH1Notch receptor 1. (2533 aa)
CD5T-cell surface glycoprotein CD5; May act as a receptor in regulating T-cell proliferation. (495 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
HHIPHedgehog interacting protein. (700 aa)
ANXA5Annexin A5; This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. (321 aa)
GLI3GLI family zinc finger 3. (1587 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1098 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
FCGR3ALow affinity immunoglobulin gamma Fc region receptor III; Is a receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Also mediates antibody-dependent cellular toxicity (By similarity). (257 aa)
EGFRReceptor protein-tyrosine kinase. (1208 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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