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GAPDH GAPDH ISL1 ISL1 ARL13B ARL13B GLI1 GLI1 GLI2 GLI2 TCTN3 TCTN3 FOXA2 FOXA2 SMO SMO PAX7 PAX7 TMEM216 TMEM216 B9D2 B9D2 GLI3 GLI3 SHH SHH IFT140 IFT140 TMEM67 TMEM67 CC2D2A CC2D2A PTCH1 PTCH1 TCTN1 TCTN1 TMEM231 TMEM231 PAX6 PAX6 CEP164 CEP164 NIN NIN IFT88 IFT88
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (376 aa)
ISL1ISL LIM homeobox 1. (349 aa)
ARL13BADP ribosylation factor like GTPase 13B. (429 aa)
GLI1GLI family zinc finger 1. (1105 aa)
GLI2GLI family zinc finger 2. (1431 aa)
TCTN3Tectonic family member 3. (599 aa)
FOXA2Forkhead box A2. (461 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
PAX7Paired box 7. (505 aa)
TMEM216Transmembrane protein 216; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. (141 aa)
B9D2B9 domain-containing protein 2; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. (175 aa)
GLI3GLI family zinc finger 3. (1587 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
IFT140Intraflagellar transport 140. (1457 aa)
TMEM67Uncharacterized protein. (996 aa)
CC2D2ACoiled-coil and C2 domain containing 2A. (1620 aa)
PTCH1SSD domain-containing protein. (1453 aa)
TCTN1Tectonic family member 1. (588 aa)
TMEM231Transmembrane protein 231; Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). (348 aa)
PAX6Paired box protein Pax-6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity); Belongs to the paired homeobox family. (436 aa)
CEP164Centrosomal protein 164. (1898 aa)
NINNinein. (2167 aa)
IFT88Intraflagellar transport 88. (850 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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