STRINGSTRING
CDK4 CDK4 RET RET TP53 TP53 CDK2 CDK2 RASA1 RASA1 NRAS NRAS STK11 STK11 SOS1 SOS1 NF2 NF2 LATS2 LATS2 MTOR MTOR CASP3 CASP3 CTNNB1 CTNNB1 RNF43 RNF43 ERBB2 ERBB2 RASGRP1 RASGRP1 MAP2K1 MAP2K1 CDKN2A CDKN2A NTRK2 NTRK2 NF1 NF1 NTRK3 NTRK3 PIK3C3 PIK3C3 PXDN PXDN ARID1A ARID1A RASGRP3 RASGRP3 BRAF BRAF ROS1 ROS1 EGFR EGFR NTRK1 NTRK1 ALK ALK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDK4Cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. [...] (303 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1114 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (386 aa)
CDK2Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] (298 aa)
RASA1Ras GTPase-activating protein 1; Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21. (1044 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (435 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
NF2Neurofibromin 2. (596 aa)
LATS2Large tumor suppressor kinase 2. (1015 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (275 aa)
CTNNB1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] (781 aa)
RNF43Ring finger protein 43. (783 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
RASGRP1RAS guanyl releasing protein 1. (797 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CDKN2AUncharacterized protein. (153 aa)
NTRK2Tyrosine-protein kinase receptor. (837 aa)
NF1Neurofibromin 1. (580 aa)
NTRK3Tyrosine-protein kinase receptor. (850 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (895 aa)
PXDNPeroxidasin. (1429 aa)
ARID1AAT-rich interaction domain 1A. (2286 aa)
RASGRP3RAS guanyl releasing protein 3. (697 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (766 aa)
ROS1Tyrosine-protein kinase receptor. (2335 aa)
EGFRReceptor protein-tyrosine kinase. (1208 aa)
NTRK1Tyrosine-protein kinase receptor. (795 aa)
ALKTyrosine-protein kinase receptor. (1451 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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