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| | MARCKS | Myristoylated alanine-rich C-kinase substrate; MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein. (333 aa) |
| | FGF8 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa) |
| | EPHA2 | EPH receptor A2. (975 aa) |
| | FOLR1 | Folate receptor alpha. (258 aa) |
| | EPHA4 | EPH receptor A4. (986 aa) |
| | FZD3 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (683 aa) |
| | SUFU | Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1249 aa) |
| | EFNA5 | Ephrin-A5; Belongs to the ephrin family. (228 aa) |
| | TBX3 | T-box transcription factor 3. (748 aa) |
| | FGF13 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa) |
| | C2CD3 | Uncharacterized protein. (364 aa) |
| | VANGL1 | Vang-like protein. (537 aa) |
| | PAK4 | Non-specific serine/threonine protein kinase. (593 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (437 aa) |
| | INVS | Inversin. (1108 aa) |
| | FGF22 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa) |
| | EPHA5 | EPH receptor A5. (1035 aa) |
| | FOLR3 | Folate receptor alpha; Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation (By similarity). (287 aa) |
| | SALL2 | Spalt like transcription factor 2. (1099 aa) |
| | SHROOM3 | Shroom family member 3. (1988 aa) |
| | MYO10 | Unconventional myosin-X; In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation (By similarity). Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate, which are then moved relative to actin filaments. Stimula [...] (2063 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa) |
| | FGF7 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa) |
| | WNT9B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa) |
| | FZD6 | Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (714 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | SCRIB | Scribble planar cell polarity protein. (1603 aa) |
| | PRICKLE1 | Prickle planar cell polarity protein 1. (900 aa) |
| | FGF14 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (184 aa) |
| | PRICKLE2 | Prickle planar cell polarity protein 2. (844 aa) |
| | CDC42 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (191 aa) |
| | ABL1 | Tyrosine-protein kinase. (1151 aa) |
| | SLC19A1 | Solute carrier family 19 member 1. (614 aa) |
| | GRHL3 | Grainyhead like transcription factor 3. (638 aa) |
| | DVL2 | Dishevelled segment polarity protein 2. (740 aa) |
| | DYNC2LI1 | Cytoplasmic dynein 2 light intermediate chain 1; Required for correct intraflagellar transport (IFT), the bi- directional movement of particles required for the assembly, maintenance and functioning of primary cilia. Involved in the regulation of ciliary length. (377 aa) |
| | KIF7 | Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1368 aa) |
| | EVL | Enah/Vasp-like. (451 aa) |
| | VANGL2 | Vang-like protein. (521 aa) |
| | FAT1 | FAT atypical cadherin 1. (4643 aa) |
| | FGF9 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | FGF17 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa) |
| | ROCK1 | Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] (1356 aa) |
| | LRP6 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa) |
| | VCL | Vinculin. (1134 aa) |
| | FGF20 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa) |
| | C2CD3-2 | C2 domain containing 3 centriole elongation regulator. (1587 aa) |
| | MTHFD1L | Monofunctional C1-tetrahydrofolate synthase, mitochondrial; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2; In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. (975 aa) |
| | CECR2 | CECR2 histone acetyl-lysine reader. (1404 aa) |
| | NUAK2 | Protein kinase domain-containing protein. (147 aa) |
| | SEC24B | SEC24 homolog B, COPII coat complex component. (1459 aa) |
| | FGF13-2 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa) |
| | SEPTIN2 | Septin-2; Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar- shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis [...] (361 aa) |
| | SMURF1 | E3 ubiquitin-protein ligase. (731 aa) |
| | SFRP1 | Secreted frizzled-related protein 1; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metane [...] (308 aa) |
| | EPHA7 | EPH receptor A7. (998 aa) |
| | GLDC | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1020 aa) |
| | ZIC2 | Zic family member 2. (525 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa) |
| | GLI3 | GLI family zinc finger 3. (1587 aa) |
| | CFL1 | Cofilin-1; Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration (By similarity); Belongs to the actin-binding protei [...] (166 aa) |
| | CDH2 | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic s [...] (1272 aa) |
| | ALX3 | ALX homeobox 3. (343 aa) |
| | NANOG | Homeobox protein NANOG; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator and repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT [...] (300 aa) |
| | CNOT1 | CCR4-NOT transcription complex subunit 1. (2376 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | VASP | Vasodilator-stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end [...] (383 aa) |
| | DACT1 | Dishevelled binding antagonist of beta catenin 1. (804 aa) |
| | DYNC2H1 | Uncharacterized protein. (1257 aa) |
| | DLX5 | Distal-less homeobox 5. (289 aa) |
| | FGF19 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa) |
| | TULP3 | Tubby-like protein; Belongs to the TUB family. (478 aa) |
| | CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. (275 aa) |
| | EFNB1 | Ephrin-B1; Belongs to the ephrin family. (346 aa) |
| | WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) |
| | ABL2 | Tyrosine-protein kinase. (1182 aa) |
| | SCARB1 | Scavenger receptor class B member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB- containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Belongs to the CD36 family. (509 aa) |
| | MSX2 | Homeobox protein MSX-2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity). (267 aa) |
| | SMO | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa) |
| | INTU | Protein inturned; Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity ef [...] (933 aa) |
| | PTK7 | Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa) |
| | FGF6 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | FGF12 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa) |
| | INKA1 | Inka box actin regulator 1. (337 aa) |
| | CDX1 | CDX1 protein. (265 aa) |
| | FGF21 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa) |
| | CITED2 | Cbp/p300-interacting transactivator 2; Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts [...] (273 aa) |
| | LHX2 | LIM homeobox 2. (406 aa) |
| | WNT11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa) |
| | TCF7L1 | Transcription factor 7 like 1. (590 aa) |
| | FAT4 | FAT atypical cadherin 4. (4982 aa) |
| | FGF3 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (236 aa) |
| | SALL1 | Spalt like transcription factor 1. (1316 aa) |
| | CELSR1 | Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (3045 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] (553 aa) |
| | FGF16 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | RAB23 | RAB23, member RAS oncogene family. (237 aa) |
| | ARL13B | ADP ribosylation factor like GTPase 13B. (429 aa) |
| | MTHFD2 | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency. (378 aa) |
| | LRP2 | LDL receptor related protein 2. (4622 aa) |
| | GRHL2 | Grainyhead like transcription factor 2. (625 aa) |
| | TTC21B | Tetratricopeptide repeat domain 21B. (1316 aa) |
| | RHOA | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] (193 aa) |
| | SALL4 | Spalt like transcription factor 4. (1061 aa) |
| | FZD1 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (645 aa) |
