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CYP2E1 CYP2E1 NR1I2 NR1I2 LOC100138004 LOC100138004 LOC781988 LOC781988 UGT1A1 UGT1A1 MGC152010 MGC152010 UGT2A1 UGT2A1 LOC540544 LOC540544 LOC530553 LOC530553 LOC100138908 LOC100138908 LOC100296421 LOC100296421 ENSBTAP00000060742 ENSBTAP00000060742 ENSBTAP00000071522 ENSBTAP00000071522 CYP2B6 CYP2B6 CYP1B1 CYP1B1 CYP1A1 CYP1A1 SLC35A2 SLC35A2 LOC615303 LOC615303 CYP3A4 CYP3A4 AHR AHR CYP3A5 CYP3A5 UGT2B10 UGT2B10 ALB ALB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CYP2E1Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. (509 aa)
NR1I2Nuclear receptor subfamily 1 group I member 2. (420 aa)
LOC100138004UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (531 aa)
LOC781988UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
UGT1A1UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (533 aa)
MGC152010UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
UGT2A1UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa)
LOC540544UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (533 aa)
LOC530553UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
LOC100138908UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (532 aa)
LOC100296421UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
ENSBTAP00000060742UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (486 aa)
ENSBTAP00000071522UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (494 aa)
CYP2B6Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
CYP1B1Uncharacterized protein; Belongs to the cytochrome P450 family. (539 aa)
CYP1A1Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (516 aa)
SLC35A2UDP-galactose translocator; Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function. (396 aa)
LOC615303UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (528 aa)
CYP3A4Uncharacterized protein. (503 aa)
AHRUncharacterized protein. (844 aa)
CYP3A5Cytochrome P450 3A28; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (507 aa)
UGT2B10UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (Probable). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The sh [...] (607 aa)
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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