8 items (Bos taurus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

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Your Input:
	LOC100125266	Intestinal-type alkaline phosphatase; Belongs to the alkaline phosphatase family. (533 aa)
	SUFU	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
	MMUT	Methylmalonyl-CoA mutase, mitochondrial; Involved in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle; Belongs to the methylmalonyl-CoA mutase family. (750 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
	GLI3	GLI family zinc finger 3. (1587 aa)
	LGALS4	Galectin-4; Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions (By similarity). (319 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (780 aa)
	GLI2	GLI family zinc finger 2. (1431 aa)

Your Current Organism:

Bos taurus

NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GLI2	GLI3	ENSBTAP00000015510	ENSBTAP00000033519	GLI family zinc finger 2.	GLI family zinc finger 3.	0.923
GLI2	SHH	ENSBTAP00000015510	ENSBTAP00000034059	GLI family zinc finger 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.905
GLI2	SMO	ENSBTAP00000015510	ENSBTAP00000017670	GLI family zinc finger 2.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.961
GLI2	SUFU	ENSBTAP00000015510	ENSBTAP00000069136	GLI family zinc finger 2.	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]	0.998
GLI3	GLI2	ENSBTAP00000033519	ENSBTAP00000015510	GLI family zinc finger 3.	GLI family zinc finger 2.	0.923
GLI3	SHH	ENSBTAP00000033519	ENSBTAP00000034059	GLI family zinc finger 3.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.899
GLI3	SMO	ENSBTAP00000033519	ENSBTAP00000017670	GLI family zinc finger 3.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.959
GLI3	SUFU	ENSBTAP00000033519	ENSBTAP00000069136	GLI family zinc finger 3.	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]	0.997
SHH	GLI2	ENSBTAP00000034059	ENSBTAP00000015510	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	GLI family zinc finger 2.	0.905
SHH	GLI3	ENSBTAP00000034059	ENSBTAP00000033519	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	GLI family zinc finger 3.	0.899
SHH	SMO	ENSBTAP00000034059	ENSBTAP00000017670	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.985
SHH	SUFU	ENSBTAP00000034059	ENSBTAP00000069136	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]	0.872
SMO	GLI2	ENSBTAP00000017670	ENSBTAP00000015510	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	GLI family zinc finger 2.	0.961
SMO	GLI3	ENSBTAP00000017670	ENSBTAP00000033519	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	GLI family zinc finger 3.	0.959
SMO	SHH	ENSBTAP00000017670	ENSBTAP00000034059	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.985
SMO	SUFU	ENSBTAP00000017670	ENSBTAP00000069136	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]	0.995
SUFU	GLI2	ENSBTAP00000069136	ENSBTAP00000015510	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]	GLI family zinc finger 2.	0.998
SUFU	GLI3	ENSBTAP00000069136	ENSBTAP00000033519	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]	GLI family zinc finger 3.	0.997
SUFU	SHH	ENSBTAP00000069136	ENSBTAP00000034059	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.872
SUFU	SMO	ENSBTAP00000069136	ENSBTAP00000017670	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.995

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